B
Omega-3/fish intake
Lifestyle & BehavioralBehavior / exposureprotectivemodifiable
38
evidence score
Also known as: Fish/omega-3 intake, fish consumption, omega 3, omega-3
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 14.1meta-analyses: 9.1trials: 15genetic: 0MR bonus:
References (25)
2 meta-analyses / systematic reviews- METAPersonalized Nutrition Biomarkers and Dietary Strategies for Atherosclerosis Risk Management: A Systematic Review. — Nutrients 2025 · PMID 40944193
- METAFood groups and risk of coronary heart disease, stroke and heart failure: A systematic review and dose-response meta-analysis of prospective studies. — Critical reviews in food science and nutrition 2017 · PMID 29039970
- Improving 10-year cardiovascular risk prediction in patients with type 2 diabetes with metabolomics. — Cardiovascular diabetology 2025 · PMID 39806417
- Gut Microbiota and Cardiovascular Diseases: Unraveling the Role of Dysbiosis and Microbial Metabolites. — International journal of molecular sciences 2025 · PMID 40362500
- Dietary, macronutrient, micronutrient, and nutrigenetic factors impacting cardiovascular risk markers apolipoprotein B and apolipoprotein A1: a narrative review. — Nutrition reviews 2024 · PMID 37615981
- Effects of vitamin D, omega-3 and a simple strength exercise programme in cardiovascular disease prevention: The DO-HEALTH randomized controlled trial. — The journal of nutrition, health & aging 2024 · PMID 38199870
- Advancements in risk stratification and management strategies in primary cardiovascular prevention. — Atherosclerosis 2024 · PMID 38824844
- Lipid profiling identifies modifiable signatures of cardiometabolic risk in children and adolescents with obesity. — Nature medicine 2024 · PMID 39304782
- Impact of Remnant Cholesterol on Cardiovascular Risk in Diabetes. — Current diabetes reports 2024 · PMID 39356419
- Triglyceride-rich lipoproteins, remnant-cholesterol, and atherosclerotic cardiovascular disease. — Current opinion in lipidology 2023 · PMID 36924359
- Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants — BMC Medicine 2022 · PMID 35692035
- Triglycerides and risk of atherosclerotic cardiovascular disease: An update. — Archives of cardiovascular diseases 2021 · PMID 33546998
- The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health. — Gut microbes 2021 · PMID 33764858
- Physical activity and metabolic syndrome severity among older adults at cardiovascular risk: 1-Year trends. — Nutrition, metabolism, and cardiovascular diseases : NMCD 2021 · PMID 34366176
- PMexposure induces systemic inflammation and oxidative stress in an intracranial atherosclerosis rat model. — Environmental toxicology 2019 · PMID 30672636
- Triglycerides and triglyceride-rich lipoproteins in the development and progression of atherosclerosis. — Current opinion in endocrinology, diabetes, and obesity 2019 · PMID 30694827
- Beyond Statins: Who and When to Prescribe? — Current diabetes reports 2018 · PMID 30324282
- Hypertriglyceridaemia and risk of coronary artery disease. — Nature reviews. Cardiology 2017 · PMID 28300080
- PM2.5 inhalation induces intracranial atherosclerosis which may be ameliorated by omega 3 fatty acids. — Oncotarget 2017 · PMID 29423081
- Emerging Risk Biomarkers in Cardiovascular Diseases and Disorders — Journal of Lipids 2015 · PMID 25949827
- Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial — BMJ 2010 · PMID 21115589
- The Preventable Causes of Death in the United States: Comparative Risk Assessment of Dietary, Lifestyle, and Metabolic Risk Factors — PLoS Medicine 2009 · PMID 19399161
- Omega-3 Augmentation of Sertraline in Treatment of Depression in Patients With Coronary Heart Disease — JAMA 2009 · PMID 19843899
- 25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men<subtitle>A Prospective Study</subtitle> — Archives of Internal Medicine 2008 · PMID 18541825
- RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis — The FASEB Journal 2005 · PMID 16373400
Clinical trials (48)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07331103 | RESOLving INflammation Through Diet for Health Multicenter, Prospective Randomized, Controlled and Open- Label to Examine the Impact of a Diet Enriched in Omega 3 Fatty Acids of Animal and Vegetal Origin on Circulating Lipid-driven Pro-/Antiinflammatory Balance in Subjects at Moderate to High Cardiovascular Risk. | RECRUITING | INTERVENTIONAL | Fish Oil, Camelina oil, Vitamin E |
| NCT07394517 | Efficacy of Phospholipid Omega-3 (Ruby-O) Versus Conventional Omega-3 on the Omega-3 Index in Patients With Mixed Dyslipidemia: A 24-Week Randomized, Double-Blind, Parallel Trial | NOT YET RECRUITING | INTERVENTIONAL | Phospholipid Omega-3, Phospholipid Omega-3, Triglyceride Omega-3 |
| NCT07241377 | A Randomized, Double-blind Placebo-controlled Study in Healthy Subjects to Compare the Bioavailability of EPA + DHA From Two Microalgal Sources in Natural Triglyceride Form to One Fish Source in Re-esterified Triglyceride Form (GOBO 2 Study) | ACTIVE NOT RECRUITING | INTERVENTIONAL | life'sTM omega O1035DS nTG, life'sTM omega O3020DS nTG, MEG-3 3323rTG |
| NCT05331807 | The Effects of Combined Omega-3 and Vitamin D Supplementation on Nutritional Status, Quality of Life and Inflammatory Markers Among the Breast Cancer Women in Gaza Strip | COMPLETED | INTERVENTIONAL | Omega-3 FA, Vitamin D, Combined Omega-3 and Vitamin D Supplementation |
| NCT06154408 | Evaluating the Impact of Omega-3 Fatty Acid Supplementation (Soloways™) on Lipid Profiles in Adults With PPARG Polymorphisms: A Randomized, Double-blind, Placebo-controlled Trial | COMPLETED | INTERVENTIONAL | omega-3 fatty acids, Placebo |
| NCT04647604 | Resolving Inflammatory Storm in COVID-19 Patients by Omega-3 Polyunsaturated Fatty Acids - A Single-blind, Randomized, Placebo-controlled Feasibility Study | COMPLETED | INTERVENTIONAL | Omegaven®, Sodium chloride |
| NCT04140201 | Evaluation of Lipid Lowering Agents on Diabetic Retinopathy and Cardiovascular Risk of Diabetic Patients | UNKNOWN | INTERVENTIONAL | Simvastatin 40mg, Fenofibrate 200mg, Omega 3 fatty acid |
| NCT03661047 | OMICC: OMega-3 Fatty Acid for the Immune Modulation of Colorectal Cancer | WITHDRAWN | INTERVENTIONAL | AMR101 (VASCEPA, icosapent ethyl) |
| NCT04301336 | Comparative Effectiveness of the Different Treatment Modalities for Management of Vaso-occlusive Painful Crisis in Pediatric Sickle Cell Disease | COMPLETED | INTERVENTIONAL | Omega 3, Vit D, Zinc sulfate |
| NCT04126330 | Effect of Omega-3 and Probiotic Dietary Supplements on Elevated High Sensitivity C-reactive Protein (Hs-CRP) as a Marker of Low-grade Inflammation: Targeting Inflammation and Intestinal Barrier Function in the Elderly and Obese | COMPLETED | INTERVENTIONAL | Probiotic, Omega-3, Vitamin D supplement, Placebo |
| NCT03127345 | Omega 3 Fatty Acid Treatment for Pediatric Musculoskeletal Health | WITHDRAWN | INTERVENTIONAL | Omegaven, Intralipid |
| NCT04051034 | Heat Therapy and Omega 3 on Metabolic and Cardiovascular Health | UNKNOWN | INTERVENTIONAL | Omega 3, Placebo |
| NCT04005573 | Assessing the Combined Effect of Omega-3 Fatty Acid and Vitamin D3 on Lipid Profile Levels and Oxidized Low Density Lipoprotein: a Randomized Controlled Trial in Males and Females With Vitamin D Deficiency | COMPLETED | INTERVENTIONAL | VD3, omega 3- FA, VD3 and omega- 3FA |
| NCT03510715 | An Open-Label Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia | COMPLETED | INTERVENTIONAL | Alirocumab SAR236553 (REGN727), Atorvastatin, Simvastatin |
| NCT03510884 | A Randomized, Double-Blind, Placebo-Controlled Study Followed by an Open Label Treatment Period to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia | COMPLETED | INTERVENTIONAL | Alirocumab SAR236553 (REGN727), Rosuvastatin, Atorvastatin |
| NCT04201938 | Probiotic With Omega-3 Fatty Acids on Obesity and Insulin Resistance Management in Patients With Type 2 Diabetes | COMPLETED | INTERVENTIONAL | Symbiter-Omega, Placebo |
| NCT02890992 | An 8-Week Open-Label, Sequential, Repeated Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia Followed by an Extension Phase | COMPLETED | INTERVENTIONAL | alirocumab SAR236553 (REGN727), statins, ezetimibe |
| NCT02762539 | Omega3 PUFA in Head Trauam | UNKNOWN | INTERVENTIONAL | omega-3 enriched SMOF lipid emusion |
| NCT02642159 | A Randomized, Open-Label, Parallel Group Study to Evaluate the Efficacy and Safety of Alirocumab Versus Usual Care in Patients With Type 2 Diabetes and Mixed Dyslipidemia at High Cardiovascular Risk With Non-HDL-C Not Adequately Controlled With Maximally Tolerated Statin Therapy | COMPLETED | INTERVENTIONAL | Alirocumab, Statins, Ezetimibe |
| NCT03072823 | Omega-3 Polyunsaturated Fatty Acids on Major Depressive Disorder in Patients With Cardiovascular Diseases: a Double-blind Placebo-controlled Therapeutic Trial | COMPLETED | INTERVENTIONAL | n-3 Polyunsaturated fatty acid, placebo |
| NCT02376621 | Nutrition Products - An Open-Label, Randomised, Single-Dose Study to Evaluate the Bioavailability of Omega-3 Based Dietary Supplements Under Fasting Conditions in Healthy Male and Female Subjects | COMPLETED | INTERVENTIONAL | PronovaPure 150:500 triglycerides, Pronovum PRF-048, Pronovum PRF-037 |
| NCT01780974 | Pilot Study: Lipoic Acid and Omega-3 Fatty Acid for Alzheimer's Disease Prevention | COMPLETED | INTERVENTIONAL | Lipoic Acid plus Omega-3 Fatty Acids, Placebo |
| NCT02036307 | Supplementation With Omega-3: Mechanism of Action | TERMINATED | INTERVENTIONAL | DHA-enriched, EPA-enriched |
| NCT04208308 | Comparison of Effect of Animal and Plant Sources of Omega-3 PUFA in Prevention of Cardiovascular and Metabolic Diseases | UNKNOWN | INTERVENTIONAL | Chia seeds supplementation (25 g), Chia seeds supplementation (15 g), Combine supplementation: chia seeds (15g) and fish oil Maxi Cor 70+20 |
| NCT02178501 | The Effect of Omega-3 Polyunsaturated Acids Supplementation on Endothelial Function, Oxidative Stress, Platelet Aggregation, Blood Coagulation and Inflammation in Patients With Type 2 Diabetes and Cardiovascular Disease | COMPLETED | INTERVENTIONAL | Omega-3 PUFA |
| NCT01301794 | Study of the Effects of Lovaza (Omega 3 Fatty Acids) On Lipoprotein Particles and Their Transcriptional Effects | UNKNOWN | INTERVENTIONAL | Omega 3 fatty acid (Lovaza) |
| NCT01521845 | Phase 3 Study of Poly Unsaturated Fatty Acids of Omega 3 as an Anti Platelet Agent on Biomarkers of Cardiac Necrosis Including CKMB and Troponin I and Inflammation Marker CRP | COMPLETED | INTERVENTIONAL | omega 3 |
| NCT02117960 | Assessing the Effects of Omega-3 Supplementation on Serum HSP27, HSP70, YKL40, BMP-4 Levels in Male Patient With Coronary Artery Disease | COMPLETED | INTERVENTIONAL | Omega-3, Placebo |
| NCT01078909 | Dose Response Effects of Marine Omega-3 Fatty Acids on Inflammation | COMPLETED | INTERVENTIONAL | Eicosapentaenoic Acid and Docosahexaenoic Acid (EPA + DHA) |
| NCT01526824 | The Effects of Polyunsaturated Omega-3 Fatty Acids (Lovaza) on Patients Taking Clopidogrel +/- Aspirin Who Have Suffered an Ischemic Stroke/TIA and/or Are Candidates for Neuroendovascular Stenting. | UNKNOWN | INTERVENTIONAL | omega-3 polyunsaturated fatty acids (Lovaza) |
| NCT01310270 | The Effects of Omega-3 Fatty Acids Supplementation on Endothelial Function and Inflammation | COMPLETED | INTERVENTIONAL | Pro-Omega, Omega 3 Fatty Acid |
| NCT01367145 | OMEGA-3-POLYUNSATURATED FATTY-ACIDS (n3-PUFA) IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE: EFFECTS ON ENDOTHELIAL FUNCTION - A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND TRIAL | COMPLETED | INTERVENTIONAL | OMACOR, Placebo |
| NCT01194063 | Use of Omegaven for Parenteral Nutrition Associated Liver Disease | COMPLETED | INTERVENTIONAL | Omega-3 fish oil lipid emulsion |
| NCT01799720 | Effect of Omega-3 Dietary Supplements With Different Oxidation Levels in the Lipidic Profile of Women: a Randomized Controlled Trial | COMPLETED | INTERVENTIONAL | Less oxidized oil and diet, More oxidized oil and diet, Hypercholesterolemic diet |
| NCT01343342 | Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors | ACTIVE NOT RECRUITING | INTERVENTIONAL | n-3 PUFA supplementation |
| NCT00915902 | Fish Oil Treatment for Dyslipidemia Associated With Children and Adolescents | COMPLETED | INTERVENTIONAL | Omega-3-acid ethyl esters, Placebo |
| NCT00826020 | Prospective Evaluation of a Parenteral Omega-3 Fatty Acid Preparation (Omegaven™) in Therapy of Patients With TPN-Induced Cholestasis | COMPLETED | INTERVENTIONAL | Omegaven™ |
| NCT01061554 | Correlation Between Level of Polyunsaturated Fatty Acid EPA and DHA in Blood After Digestion of ProBios Omega-3 Concordix™ Compared With Omega-3 Soft Capsules - a Pilot | COMPLETED | INTERVENTIONAL | Omega-3 oils from tri-glycerides, Omega-3 oils from marine phospholipids |
| NCT00729430 | Prognostic, Anti-arrhythmic, and Ventricular Remodeling Effects of High Dose Fish Oil in Patients With a Recent Myocardial Infarction | COMPLETED | INTERVENTIONAL | Omega-3 Fatty Acids (Fish Oil Supplements), Placebo |
| NCT00734916 | Immune Modulation by Omega-3 Versus Omega-6 Based Parenteral Lipids in Healthy Volunteers | COMPLETED | INTERVENTIONAL | Parenteral lipid emulsion (Omegaven), Parenteral lipid emulsion (Intralipid), Parental lipid emulsion (Saline 0.9%) |
| NCT00435045 | A Randomized, Double-Blind, Placebo-Controlled, Forced Titration Study to Assess the Efficacy and Safety of Omacor, Co-Administered With Open-Label Atorvastatin Therapy, in Hypertriglyceridemic Subjects | COMPLETED | INTERVENTIONAL | Lovaza (omega-3-acid ethyl esters) [formerly known as Omacor] plus atorvastatin, atorvastatin |
| NCT00402363 | A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial to Assess the Efficacy and Safety of Lovaza for the Prevention of Recurrent, Symptomatic Atrial Fibrillation | COMPLETED | INTERVENTIONAL | omega-3-acid ethyl esters, Placebo |
| NCT00141232 | A Multicentre, Randomised, Double Blind Placebo Controlled Trial Evaluating Atorvastatin in Factorial With Omega-3 Fatty Acids Cardiovascular Risk Reduction in Patients With Type 2 Diabetes | COMPLETED | INTERVENTIONAL | Atorvastatin and Omega-3 fatty acids |
| NCT00153764 | Effectiveness of a One-a-Day Cooper Complete Vitamin / Mineral Supplement With or Without Omega-3 Fatty Acid Ingestion | COMPLETED | INTERVENTIONAL | Cooper Complete One-A-Day Vitamin Supplement |
| NCT00620672 | To Compare Measures of Central Nervous System Maturity of Visual Acuity, Language, Mental and Motor Skill Development in Term Infants Following Maternal Supplementation Wit the n-3 Fatty Acid Docosahexaenoic Acid (DHA) During Gestation. | COMPLETED | INTERVENTIONAL | omega 3 fatty acids, vegetable oil |
| NCT00257283 | A Double Blind Comparison of Omacor and Placebo as Secondary Prevention Against Cardiovascular Events in Patients Undergoing Chronic Hemodialysis | COMPLETED | INTERVENTIONAL | Omega-3-acid ethyl esters 90 |
| NCT00764010 | Diet and Omega-3 Intervention Trial on Atherosclerosis | COMPLETED | INTERVENTIONAL | No dietary counseling and omega-3 capsules, Omega-3 capsules and dietary counseling, Dietary counseling, placebo capsules for omega-3 |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | COMPLETED | INTERVENTIONAL | pravastatin, niacin, cholestyramine |
Genetic associations (0)
None linked.