B
Osteoporosis/low bone mineral density
Comorbid ConditionsDisease / conditionriskpartially modifiable
35
evidence score
Also known as: Osteoporosis, bone mineral density, osteoporosis
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 14.9meta-analyses: 9.1trials: 11.1genetic: 0MR bonus:
References (30)
2 meta-analyses / systematic reviews- METAIdentified risk factors for dry eye syndrome: A systematic review and meta-analysis. — PloS one 2022 · PMID 35984830
- METAEffect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis — BMJ 2010 · PMID 20671013
- Relationship of Chronic Stress and Hypertension with Bone Resorption. — Journal of functional morphology and kinesiology 2025 · PMID 39846662
- Calcium Supplementation- Efficacy and Safety. — Current osteoporosis reports 2025 · PMID 39937345
- Association between BMD and coronary artery calcification: an observational and Mendelian randomization study. — Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 · PMID 38477752
- Clinical manifestations of rheumatoid arthritis, including comorbidities, complications, and long-term follow-up. — Best practice & research. Clinical rheumatology 2024 · PMID 39489658
- Hyperhomocysteinemia and Disease-Is 10 μmol/L a Suitable New Threshold Limit? — International journal of molecular sciences 2024 · PMID 39596358
- Clonal haematopoiesis and dysregulation of the immune system. — Nature reviews. Immunology 2023 · PMID 36941354
- Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses — Frontiers in Pharmacology 2022 · PMID 36353491
- Osteoporosis and cardiovascular disease: a review. — Molecular biology reports 2022 · PMID 36449152
- Sleep duration and health outcomes: an umbrella review. — Sleep & breathing = Schlaf & Atmung 2021 · PMID 34435311
- Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next? — ACS Pharmacology & Translational Science 2021 · PMID 34927008
- Common mechanisms and holistic care in atherosclerosis and osteoporosis. — Arthritis research & therapy 2019 · PMID 30630495
- Disturbed homocysteine metabolism is associated with cancer — Experimental & Molecular Medicine 2019 · PMID 30804341
- Ethanol and its metabolites: update on toxicity, benefits, and focus on immunomodulatory effects. — Drug metabolism reviews 2019 · PMID 31646907
- Childhood Lead Exposure and Adult Neurodegenerative Disease. — Journal of Alzheimer's disease : JAD 2018 · PMID 29865081
- Peripheral artery disease and osteoporosis: Not only age‑related (Review). — Molecular medicine reports 2018 · PMID 30272311
- Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases. — Gut 2017 · PMID 28314735
- The genetic basis of obesity complications. — Acta scientiarum polonorum. Technologia alimentaria 2017 · PMID 28362475
- The metabolism and significance of homocysteine in nutrition and health — Nutrition & Metabolism 2017 · PMID 29299040
- Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016. — BMC health services research 2016 · PMID 27409075
- Adverse effects of glucocorticoids: coagulopathy. — European journal of endocrinology 2015 · PMID 25971647
- Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases — Scandinavian Journal of Medicine and Science in Sports 2015 · PMID 26606383
- Lack of Exercise Is a Major Cause of Chronic Diseases — Comprehensive physiology 2012 · PMID 23798298
- Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. — Journal of inherited metabolic disease 2010 · PMID 20814827
- Plant Polyphenols as Dietary Antioxidants in Human Health and Disease — Oxidative Medicine and Cellular Longevity 2009 · PMID 20716914
- Arterial Stiffness and Osteoporosis in Chronic Obstructive Pulmonary Disease — American Journal of Respiratory and Critical Care Medicine 2007 · PMID 17363772
- Evidence for prescribing exercise as therapy in chronic disease — Scandinavian Journal of Medicine and Science in Sports 2006 · PMID 16451303
- Detection of Homocysteine and Cysteine — Journal of the American Chemical Society 2005 · PMID 16277539
- Homocysteine Levels and the Risk of Osteoporotic Fracture — New England Journal of Medicine 2004 · PMID 15141041
Clinical trials (12)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT06745544 | Impact of Screening and Multicomponent Exercise on Fall Rates, Fractures, and Cardiovascular Health in Diabetes: Protocol for a Randomized Control Trial: DIACTIVE | RECRUITING | INTERVENTIONAL | Rhythm- and Multitask-Based Activity (RYMA) and Activities of Daily Living (ADL) |
| NCT03534934 | CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD | COMPLETED | INTERVENTIONAL | Vital signs, Urine Pregnancy Test, Questionnaires |
| NCT02789800 | Patient-Centred Innovations for Persons With Multimorbidity - Quebec | COMPLETED | INTERVENTIONAL | DIMAC02 |
| NCT02742597 | Patient-Centred Innovations for Persons With Multimorbidity - Ontario | COMPLETED | INTERVENTIONAL | TIP / IMPACT Plus Care Coordination |
| NCT01250314 | Radiological, Biological, Genetic and Micro-architectural Bone Determinants of Fractures in Men With Low Bone Mineral Density | COMPLETED | INTERVENTIONAL | Radiology, Biological, biochemical and genetic samples |
| NCT00639210 | BREAST CANCER AND EXERCISE BREX: A Multicenter Phase III Open Randomised Trial of the Efficacy of Exercise in the Prevention of Long-term Adverse Effects of Adjuvant Treatments and Breast Cancer Recurrences in Women With Primary Breast Cancer. | COMPLETED | INTERVENTIONAL | supervised training |
| NCT00204412 | Effectiveness of Flax Lignan and Exercise Training for Improving Lipid Profiles | COMPLETED | INTERVENTIONAL | Flax lignan, Exercise (walking) |
| NCT06065852 | National Registry of Rare Kidney Diseases (RaDaR) | RECRUITING | OBSERVATIONAL | |
| NCT06473168 | Walking-related Mobility Assessment in Older People With Multimorbidity | UNKNOWN | OBSERVATIONAL | |
| NCT04821492 | Evaluation of the Relationship Between Homocysteine Levels and Bone Mineral Density in Postmenopausal Women | COMPLETED | OBSERVATIONAL | Dual-Energy X-ray Absorptiometry (DXA) |
| NCT03835793 | Favourable and Unfavourable Health Effects of Risk-Reducing Salpingo-Oophorectomy in Women With a High Genetic Risk of Ovarian Cancer | UNKNOWN | OBSERVATIONAL | CAC-score |
| NCT03401619 | Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study: an Ambispective, Multicentre, Open Cohort Study | ACTIVE NOT RECRUITING | OBSERVATIONAL | Exercise，Nutrition，Bisphosphonates，Statins，Calcitonin,Vitamin D，et al. |
Genetic associations (0)
None linked.