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Overweight/obesity

Anthropometric & Body CompositionPhysical parameterriskmodifiable
56
evidence score

Also known as: Overweight, overweight, overweight and obesity in adults (54.5% in white men, 58.5% in African women), overweight status

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 20.5meta-analyses: 20trials: 15genetic: 0MR bonus:

References (110)

10 meta-analyses / systematic reviews

Clinical trials (104)

showing top 60
NCTTitleStatusTypeInterventions
NCT07578584Investigation of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneous Weekly Doses of NNC0497-0040 in Healthy Participants, Participants With Overweight or Obesity, and in Participants With Type 1 Diabetes With Overweight or ObesityRECRUITINGINTERVENTIONALNNC0497-0040, Placebo
NCT07529704Evaluation of a Tailored Multicomponent Early Intervention for Childhood Obesity Prevention in Vulnerable Families (Bambú Project): Randomized Controlled Trial With a Hybrid Type 1 Effectiveness-implementation DesignRECRUITINGINTERVENTIONALBambú program
NCT07368777Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass ReductionRECRUITINGINTERVENTIONALGenotype-Based Dietary Counseling, Standard Dietary Counseling
NCT06952348HYPERtension Reduction Through WALKing Stairs Versus Brisk Walking in Individuals With Increased Cardiometabolic Risk - The HYPERWALK Randomized Controlled TrialRECRUITINGINTERVENTIONALStair and brisk walking combined, Brisk walking, Standard care
NCT06988462Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" FoodRECRUITINGINTERVENTIONALBottarga, Comparator
NCT07134335A Phase II Clinical Study to Evaluate the Efficacy and Safety of UBT251 Injection in Obese/Overweight Chronic Kidney Disease (CKD) PopulationRECRUITINGINTERVENTIONALUBT251, UBT251, UBT251
NCT06619041Harnessing the Power of Social Support for Weight Management: a Randomized Controlled Trial of HealthyTogetherRECRUITINGINTERVENTIONALHealthyTogether
NCT06671119REvision of VSG with Ablation of the Mucosa ProcedureRECRUITINGINTERVENTIONALGastric Mucosal Ablation (GMA)
NCT06517212Adjuvant Tirzepatide Plus Standard of Care Endocrine Therapy in Patients With Obesity or Overweight Who Have Hormone Receptor-positive, HER2-negative, Node-positive Early Breast Cancer, With Molecular Residual Disease (MRD), as Determined by Circulating Tumor DNA (ctDNA)RECRUITINGINTERVENTIONALTirzepatide
NCT06547775A Randomized, Double-blind and Placebo-controlled Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of KN069 in Chinese Male Participants With Obesity or OverweightRECRUITINGINTERVENTIONALKN069
NCT07447362Effect of a Structured Clinical and Pharmacological Management Strategy on Cardiovascular Risk Factors in Adult Patients in Routine Clinical Practice: A Pseudo-Experimental Before-and-After StudyRECRUITINGINTERVENTIONALStructured Cardiovascular Risk Management
NCT05987410EffectiVenEss of a Rehabilitation Treatment With Nordic Walking in obEse or oveRweight Diabetic patiEnts With Cardiovascular Disease. The VENERE StudyRECRUITINGINTERVENTIONALNordic Walking (NW), Standard Rehabilitation (SR), Cardiological Counselling (CC)
NCT05844644An Open Label Study Evaluating the Effects of the GOLO for Life® Plan With Release Supplement on Glycemic Control and Weight in Overweight and Obese Adults With Prediabetes or Type 2 DiabetesRECRUITINGINTERVENTIONALRelease
NCT07485764A Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial to Evaluate the Efficacy and Safety of Metformin in Combination With Secukinumab for the Treatment of Moderate-to-Severe Plaque Psoriasis in Overweight or Obese Chinese PatientsNOT YET RECRUITINGINTERVENTIONALSecukinumab 300mg s.c., Metformin, Placebo
NCT07566325Effects of Avocado Consumption on Inflammation and Insulin Sensitivity in Adults With Elevated High Sensitivity-C-reactive Protein (Hs-CRP): A Randomized, Controlled Crossover TrialNOT YET RECRUITINGINTERVENTIONALAvocado, Control
NCT07274137A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Clinical Study to Evaluate the Efficacy and Safety of MDR-001 Administered Orally Over 52 Weeks in Participants With Overweight or Obesity (MOBILE)NOT YET RECRUITINGINTERVENTIONALMDR-001, Placebo
NCT07209527Evaluation of Truway Health-Sourced Portable Diagnostic Devices for Early Detection of Chronic Conditions in Outpatient Primary Care Settings: A Prospective Interventional StudyENROLLING BY INVITATIONINTERVENTIONALTruway Portable Ultrasound Device, Truway Blood Glucose Monitor, Standard Oral Hypoglycemic Agent
NCT07137585Effects of RO7204239 on Insulin Sensitivity, Muscle Composition and Function in Participants Living With Type 2 Diabetes Mellitus and Overweight or Obesity: A Double-blind, Randomized, Placebo-controlled StudyACTIVE NOT RECRUITINGINTERVENTIONALPlacebo, RO7204239
NCT07045272Study on the Construction and Effectiveness of a Digital Behavioral Intervention Program for Overweight and Obese Patients Prior to Assisted Reproductive Technology(ART)TreatmentNOT YET RECRUITINGINTERVENTIONALExperimental
NCT07104383A Phase 3 Randomized, Double-Blind, Placebo-Controlled, 78-Week Efficacy and Safety Study of VK2735 Administered Subcutaneously for Weight Management in Participants With Type 2 Diabetes Who Are Obese, or OverweightACTIVE NOT RECRUITINGINTERVENTIONALVK2735
NCT06979830The Effects of Yoga Exercises on Body Composition, Respiratory Parameters and Functional Levels in Overweight and Obese Women: A Randomized Controlled TrialNOT YET RECRUITINGINTERVENTIONALyoga exercises
NCT06926842A Randomized, Double-Blind, Phase 2 Trial of Once-Weekly Petrelintide Compared With Placebo in Participants With Overweight or Obesity and Type 2 DiabetesACTIVE NOT RECRUITINGINTERVENTIONALPetrelintide, Placebo
NCT07429045A Phase 1, Open-label, Single-dose, Parallel Group Study to Assess the Pharmacokinetics, Safety, and Tolerability of AMG 133 in Participants With Normal Renal Function and Participants With Various Degrees of Renal ImpairmentCOMPLETEDINTERVENTIONALAMG 133
NCT06712836A Phase 2b, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study of 28 Weeks to Investigate the Safety and Efficacy of Once-Weekly MET097 in Adults With Obesity or Overweight Followed by a 32-Week Extension (VESPER-1)COMPLETEDINTERVENTIONALMET097, Placebo
NCT06267092An Investigation of the Effect of Cagrilintide and Semaglutide Combination Treatment (CagriSema) on Appetite and Functional Brain Activity in People With Overweight or ObesityCOMPLETEDINTERVENTIONALNo treatment given, Cagrilintide and Semaglutide, Placebo
NCT07230873The Impact of Stationary Combined Exercise on Adiponectin and High-Sensitivity C-Reactive Protein Levels in Overweight WomenCOMPLETEDINTERVENTIONALCombined Exercise Group, No Structured Exercise
NCT06149793Empagliflozin in CFRD: Efficacy and Safety of SGLT2 Inhibitor Therapy in Overweight and Obese Subjects With Cystic Fibrosis-related Diabetes: a Pilot StudyACTIVE NOT RECRUITINGINTERVENTIONALEmpagliflozin, Placebo Control
NCT07461740The Impact of Mindful Eating Education on Hedonic Hunger in Obese AdultsCOMPLETEDINTERVENTIONALMindful eating training
NCT05814107A Double-Blind, Randomized, Placebo-Controlled Phase 1 Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of CT-996 in Overweight/Obese Participants and in Patients With Type 2 Diabetes MellitusCOMPLETEDINTERVENTIONALCT-996, Placebo
NCT05934110A 26-week, Double-blind, Randomized Study in Participants With Overweight or Obesity Investigating the Added Contribution of Acarbose in EMP16 on Efficacy, Safety and TolerabilityUNKNOWNINTERVENTIONALEMP16-120/40, MR orlistat 120 mg, Conventional orlistat 120 mg,
NCT05761301A Phase 1/2, Randomized, Double-blind, Placebo-controlled, 2-Part Study of the Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Single Dose ALN-KHK in Overweight to Obese Adult Healthy Volunteers and Multiple Dose ALN-KHK in Obese Patients With Type 2 Diabetes Mellitus (T2DM)TERMINATEDINTERVENTIONALALN-KHK, Placebo
NCT05560971The Effect of Palmitoleic Acid (POA) Supplementation on Insulin Sensitivity and Lipogenesis in Overweight and Obese IndividualsACTIVE NOT RECRUITINGINTERVENTIONALPalmitoleic acid, Placebo
NCT05564117Efficacy and Safety of Oral Semaglutide 25 mg Once Daily in Adults With Overweight or ObesityCOMPLETEDINTERVENTIONALSemaglutide, Placebo semaglutide
NCT05511025A Phase I Randomized Single-blind Placebo-controlled Study to Assess the Safety, Tolerability, and Pharmacokinetics of AZD6234 Following Single Ascending Dose Administration to Healthy Subjects Who Are Overweight or ObeseCOMPLETEDINTERVENTIONALAZD6234, Placebo, Acetaminophen
NCT05349500Optimizing Osteoarthritis Care Through Clinical and Community PartnershipCOMPLETEDINTERVENTIONALOA CARE Intervention, Usual Care control group
NCT05095038A Six Month Randomized Placebo-controlled Trial of Appethyl® vs Placebo in Management of Pre-diabetes on Overweight and Obese IndividualsTERMINATEDINTERVENTIONALAppethyl®, Placebo
NCT04897698LB001 Study: Probiotics for Weight Loss: A Randomized Controlled StudyCOMPLETEDINTERVENTIONALLB001
NCT04439019Group Education and Digitally Delivered Lifestyle Modification Program to Enable Weight Loss and Improve Metabolic Health and Quality of Life for Patients with Osteoarthritis and Overweight/obesity.WITHDRAWNINTERVENTIONALLifestyle and dietary modification program
NCT05063253A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Study to Evaluate the Efficacy of TG103 Injection in Overweight/Obese Subjects With Type 2 Diabetes MellitusUNKNOWNINTERVENTIONALTG103, Placebo
NCT04876027Dulaglutide and Calorie Restrict Diet (CRD) in Overweight/Obese Patients With Polycystic Ovary SyndromeCOMPLETEDINTERVENTIONALGLP-1 RAs, calorie restricted diet
NCT04567108SUBstituting With Preferred Options: Health Effects of Substituting Sugar-sweetened Beverages With Non-caloric Beverages in Adults With Overweight and ObesityACTIVE NOT RECRUITINGINTERVENTIONALMaintain usual SSBs, Substitute to non-SSBs, Study app
NCT04623008Using Mental Imagination to Prevent Excessive Gestational Weight Gain in Overweight and Obese Pregnant WomenCOMPLETEDINTERVENTIONALGoal-Oriented Episodic Future Thinking
NCT04436692Dietary Intervention in Overweight Subjects With Intellectual Disabilties Using the Nudging Approach as MethodCOMPLETEDINTERVENTIONALNudging
NCT04493567An Open-label, Randomized, Two-period Cross-over Study to Investigate the Relative Bioavailability of BMS-986036 in Healthy, Overweight, and Obese Participants Following Subcutaneous Administration Via Auto-injector Versus Pre-filled SyringeCOMPLETEDINTERVENTIONALBMS-986036
NCT04351672Time-restricted Feeding as a Dietary Strategy Against Metabolic Disturbances in HumansCOMPLETEDINTERVENTIONALEarly Time-Restricted Feeding, Late Time-Restricted Feeding
NCT04120220Shake It Up: Lipidomics of Lipoproteins and DietTERMINATEDINTERVENTIONALHeavy Cream, Soybean Oil
NCT03426956Impact of Canaglifloxin on Gut Hormone Secretion After Gastric BypassUNKNOWNINTERVENTIONALGlucose, Glucose + Canagliflozin
NCT03151005Randomized Clinical Trial to Evaluate The Effect of Metformin-GLP-1 Receptor Agonist Versus Oral Contraceptive (OC) Therapy on Reproductive Disorders and Cardiovascular Risks in Overweight Polycystic Ovarian Syndrome (PCOS) PatientsCOMPLETEDINTERVENTIONALMetformin-GLP-1 Receptor Agonist, Metformin-Oral Contraceptive(OC)
NCT03060525Deaf Weight Wise 2.0: Clinical Trial of a Healthy Lifestyle Intervention With Deaf Adults Ages 21 to 70COMPLETEDINTERVENTIONALDeaf Weight Wise 2.0
NCT03186196Influence of Polymorphism C677T MTHFR and Folate Intake in Interleukins, Homocysteine and TNF-αCOMPLETEDINTERVENTIONALDiet containing Folate
NCT03310307Vitamin D3 Treatment Decreases Serum Total Homocysteine Concentrations of Overweight Reproductive Women: Randomized Placebo Controlled Clinical TrailCOMPLETEDINTERVENTIONALVit D, Placebo
NCT02953522Polymorphism C677T MTHFR and Diet With Folate in Oxidative Stress, Lipid Profile and HomocysteineCOMPLETEDINTERVENTIONAL191 mcg/day of Folate, 90 mcg / day of Folate
NCT02568306A First Human Dose Trial Investigating Safety, Tolerability and Pharmacokinetics for Single Doses and Multiple Doses of NNC0165-1562 in Overweight to Obese But Otherwise Healthy Subjects.COMPLETEDINTERVENTIONALNNC0165-1562, placebo
NCT03423719Effect of a 16-week Supplementation With a Mediterranean Fruit and Vegetables Extract Rich in Polyphenols, Fiit-ns®, on Health-related Quality of Life of Overweight and Obese Volunteers: a Randomized, Double-blind, Parallel TrialCOMPLETEDINTERVENTIONALFiit-ns®, Placebo
NCT03248804The Effect of Incorporating Soy Protein Foods in the Colorado Diet for Weight Loss and Maintenance.COMPLETEDINTERVENTIONALSoy group, Non-soy group
NCT0282963212 Weeks Weight Loss Study Using Feedback Messages Delivered Via SmartphoneCOMPLETEDINTERVENTIONALGroup Sessions, Feedback, Self-monitoring
NCT02360774Mechanisms of Weight Loss With SGLT2 InhibitionCOMPLETEDINTERVENTIONALCanagliflozin, Placebo
NCT02821637Impact of an Effort Rehabilitation Program for Overweight or Obese Children and Teens on Quality of Life and Wellbeing: A French Monocentric Prospective StudyCOMPLETEDINTERVENTIONALEurofit Tests of Physical Fitness (Eurofit), Child Health Questionnaire (CHQ), Effort rehabilitation program
NCT02246699A Study to Evaluate the Efficacy and the Safety of a Fungal Chitosan on the Body Weight Reduction in Overweight and Obesity Volunteers: a Randomized, Double-blind, Parallel Groups and Placebo Controlled Clinical Trial.COMPLETEDINTERVENTIONALKiOnutrime®-Cs, Placebo
NCT02136290Randomized Clinical Trial of Portion-Controlled Prepackaged Foods to Promote Weight Loss - CHOICES Study.COMPLETEDINTERVENTIONALPrepackaged meals, Usual Care

Genetic associations (0)

None linked.