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Oxidative stress

Novel & Emerging BiomarkersLab test / biomarkerriskpartially modifiable
51
evidence score

Also known as: increased oxidative stress, oxidative imbalance, oxidative metabolism, oxidative stress / reactive oxygen species, oxidative stress / superoxide, oxidative stress generation, reactive oxygen species, reactive oxygen species / oxidative stress, reactive oxygen species generation, superoxide radicals

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 24.8meta-analyses: 13.8trials: 12.7genetic: 0MR bonus:

References (299)

4 meta-analyses / systematic reviews

Clinical trials (18)

NCTTitleStatusTypeInterventions
NCT03036644Effects of Electronic Cigarette Vaporization at High Temperature in Comparison to Tobacco Smoking on Cardiovascular Function and Oxidative Stress in Electronic Cigarette Users and Regular Tobacco SmokersCOMPLETEDINTERVENTIONALe-cigarette (PG+VG without nicotine; low temperature), e-cigarette (PG+VG with nicotine; low temperature), e-cigarette (PG+VG without nicotine; high temperature)
NCT02840357The Purple Wheat Intervention Study: Impact of Purple Wheat Consumption on Markers of Inflammation and Oxidative Stress in Adults.COMPLETEDINTERVENTIONALPurple Wheat Convenience Bars, Control Wheat Convenience Bars
NCT02953522Polymorphism C677T MTHFR and Diet With Folate in Oxidative Stress, Lipid Profile and HomocysteineCOMPLETEDINTERVENTIONAL191 mcg/day of Folate, 90 mcg / day of Folate
NCT02321579The Effects of Vitamin B-6 and Glutathione on Inflammatory Responses, Homocysteine Metabolism, Oxidative Stress and Antioxidant Capacities in Patients With Liver Cirrhosis or Hepatocellular CarcinomaUNKNOWNINTERVENTIONALvitamin B-6, Glutathione, Dextrins
NCT03402204Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patients With Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, Controlled TrialCOMPLETEDINTERVENTIONALSimvastatin 10 mg, Simvastatin 40 mg
NCT02178501The Effect of Omega-3 Polyunsaturated Acids Supplementation on Endothelial Function, Oxidative Stress, Platelet Aggregation, Blood Coagulation and Inflammation in Patients With Type 2 Diabetes and Cardiovascular DiseaseCOMPLETEDINTERVENTIONALOmega-3 PUFA
NCT02862860Influence of Glycaemic Variability on Oxidative Stress and High-density Lipoprotein (HDL) Function in Type-1 DiabetesCOMPLETEDINTERVENTIONALblood sample, urine sample, installation of Holter
NCT01424761Coenzyme Q10 in Relation to the Antioxidative Vitamins, Oxidative Stress and Inflammation in Coronary Artery Disease Patients During Statin TherapyCOMPLETEDINTERVENTIONALCoenzyme Q10, Placebo
NCT01426490The Effects of Vitamin B-6 Status on Homocysteine, Oxidative Stress, One-carbon Metabolism and Methylation: Cross-section, Case-control, Intervention and Follow-up Studies in Colorectal CancerUNKNOWNINTERVENTIONALVitamin C, Vitamin B6, Folic acid
NCT00597376A Six-month, Double-blind, Placebo-controlled, Single Site Study of Cerefolin NAC on Blood Homocysteine, Oxidative Stress, and Beta-amyloid Biomarkers That May Potentiate Inflammation and Neuronal Damage in Older Individuals With Memory Complaints Who Have Not Been Clinically Diagnosed With Mild Cognitive Impairment, Vascular Dementia, or Alzheimer's DiseaseCOMPLETEDINTERVENTIONALCerefolin NAC (a medical food), Cerefolin NAC placebo
NCT00384618Effect of an Oxidative-Stress-Reducing Strategy Consisting of Pravastatin, Vitamin E and Homocysteine-Lowering on Carotid Intima-Media Thickness in Patients With Mild-to-Moderate Chronic Kidney DiseaseTERMINATEDINTERVENTIONALpravastatin, vitamin E
NCT06585761Effect of Sodium Glucose Co-tansporter 2 Inhibitors (SGLT2I) on Inflammatory and Oxidative Stress Markers Level in Heart Failure PatientsRECRUITINGOBSERVATIONALSGLT2 inhibitor, echo cardiogram
NCT04694703Changing of Trace Element, Homocysteine, Oxidative Stress Parameters and Physical Activity Levels in Patients Diagnosed With COVID-19 Before and After COVID-19 TreatmentCOMPLETEDOBSERVATIONALCovid-19 group
NCT04695158Determination of Hemoglobin A1c, Lipid Profiles, Homocysteine, Oxidative Stress Parameters and Physical Activity Levels in Patients With Type II Diabetes and/or COVID-19UNKNOWNOBSERVATIONALCOVID-19 group (Group I), Type II Diabetes Mellitus and COVID-19 group (Group II)
NCT05652426The Effect of Hypoxic and Normoxic Cerebral Oximetry Levels and Oxidative Stress on Cognitive Functions After Carotid EndarterectomyCOMPLETEDOBSERVATIONAL
NCT03310450Predictors of Cardiac Troponin Release After Tour de Borobudur 2017COMPLETEDOBSERVATIONAL140kms cycling
NCT05214872Assessment of the Impact of Selected Factors on the Cardiovascular System in Patients With Different Chronic Kidney Disease StagesCOMPLETEDOBSERVATIONALlaboratory parameters - complete blood count, body mass index (BMI) [kg/m^2] calculation, selected parameters of oxidative stress (1)
NCT03553381Oxidative Stress, Inflammation, and Lipoprotein Chemical Composition in Obesity and Metabolic Syndrome: Effects of Diet-induced Weigh LossCOMPLETEDOBSERVATIONALhypocaloric balanced diet

Genetic associations (0)

None linked.