A
Oxidized LDL
Lipids & LipoproteinsLab test / biomarkerriskmodifiable
32
evidence score
Also known as: Oxidized lipoproteins (oxidLDL), Oxidized low-density lipoprotein (LDL), ox-ldl, oxidized lipoproteins, oxidized low-density, oxidized low-density lipoproteins (oxLDL)
PREVENT status
Not a PREVENT input variable.
Causal support
observational only
Score components
lit volume: 15.4meta-analyses: 11.6trials: 4.8genetic: 0MR bonus:
References (34)
3 meta-analyses / systematic reviews- METAImmunotherapy and vaccine-based approaches for atherosclerosis prevention: a systematic review study. — BMC cardiovascular disorders 2025 · PMID 40114074
- METAEffects of phytosterols on cardiovascular risk factors: A systematic review and meta-analysis of randomized controlled trials. — Phytotherapy research : PTR 2024 · PMID 39572895
- METAOxidized low-density lipoprotein associates with cardiovascular disease by a vicious cycle of atherosclerosis and inflammation: A systematic review and meta-analysis. — Frontiers in cardiovascular medicine 2023 · PMID 36727024
- Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways. — European journal of medical research 2025 · PMID 40319296
- Lipid Toxicity in the Cardiovascular-Kidney-Metabolic Syndrome (CKMS). — Biomedicines 2024 · PMID 38790940
- Challenges and advances in the management of inflammation in atherosclerosis. — Journal of advanced research 2024 · PMID 38909884
- Atherogenic low-density lipoprotein and cardiovascular risk. — Current opinion in lipidology 2024 · PMID 39641158
- Atorvastatin ameliorated PM-induced atherosclerosis in rats. — Archives of environmental & occupational health 2023 · PMID 36660941
- Oxidized phospholipids in cardiovascular disease. — Nature reviews. Cardiology 2023 · PMID 37848630
- An integrative analysis of single-cell and bulk transcriptome and bidirectional mendelian randomization analysis identified C1Q as a novel stimulated risk gene for Atherosclerosis. — Frontiers in immunology 2023 · PMID 38179058
- Systemic lupus erythematosus and cardiovascular disease. — Journal of internal medicine 2022 · PMID 35982610
- LDR-adapted liver-derived cytokines have potential to induce atherosclerosis. — International journal of radiation biology 2022 · PMID 36383216
- Molecular and Cellular Mechanisms of Electronegative Lipoproteins in Cardiovascular Diseases — Biomedicines 2020 · PMID 33260304
- Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation — Oxidative Medicine and Cellular Longevity 2019 · PMID 31354915
- The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (I) - Contribution to the Elucidation of the Pathophysiology of Human Hypercholesterolemia and Coronary Heart Disease. — Journal of atherosclerosis and thrombosis 2019 · PMID 31748469
- Oxidative burden in familial hypercholesterolemia. — Journal of cellular physiology 2018 · PMID 29323716
- NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis. — Circulation research 2018 · PMID 29880500
- Triglyceride Rich Lipoprotein -LPL-VLDL Receptor and Lp(a)-VLDL Receptor Pathways for Macrophage Foam Cell Formation. — Journal of atherosclerosis and thrombosis 2017 · PMID 28428482
- MicroRNA-214-3p: A link between autophagy and endothelial cell dysfunction in atherosclerosis. — Acta physiologica (Oxford, England) 2017 · PMID 28888077
- Homocysteine, iron and cardiovascular disease: a hypothesis. — Nutrients 2015 · PMID 25668155
- Fusobacterium nucleatum Alters Atherosclerosis Risk Factors and Enhances Inflammatory Markers with an Atheroprotective Immune Response in ApoEnull Mice — PLoS ONE 2015 · PMID 26079509
- Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis. — Arteriosclerosis, thrombosis, and vascular biology 2014 · PMID 24554606
- LOX-1 in atherosclerotic disease. — Clinica chimica acta; international journal of clinical chemistry 2014 · PMID 25463747
- Atherosclerosis: process, indicators, risk factors and new hopes. — PubMed 2014 · PMID 25489440
- Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases — Critical Reviews in Clinical Laboratory Sciences 2014 · PMID 25537066
- Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice. — Circulation research 2013 · PMID 24255059
- [Dyslipidemia and atherosclerosis]. — Nihon rinsho. Japanese journal of clinical medicine 2011 · PMID 21226274
- The levels of adiponectin and leptin and their relation to other markers of cardiovascular risk in patients with psoriasis — Journal of the European Academy of Dermatology and Venereology 2011 · PMID 21349112
- Cross-sectional associations between physical activity and selected coronary heart disease risk factors in young adults. The Cardiovascular Risk in Young Finns Study — Annals of Medicine 2011 · PMID 21721849
- Cardiovascular Disease Parameters in Periodontitis — Journal of Periodontology 2009 · PMID 19254121
- Nonconcordance between subclinical atherosclerosis and the calculated Framingham risk score in HIV‐infected patients: relationships with serum markers of oxidation and inflammation — HIV Medicine 2009 · PMID 19845792
- The macrophage at the crossroads of insulin resistance and atherosclerosis. — Circulation research 2007 · PMID 17556668
- Is there more than C-reactive protein and fibrinogen? The prognostic value of soluble CD40 ligand, interleukin-6 and oxidized low-density lipoprotein with respect to coronary and cerebral vascular disease. — Atherosclerosis 2005 · PMID 16360159
- Inflammation in Atherosclerosis and Implications for Therapy — Circulation 2004 · PMID 15198962
Clinical trials (2)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT04005573 | Assessing the Combined Effect of Omega-3 Fatty Acid and Vitamin D3 on Lipid Profile Levels and Oxidized Low Density Lipoprotein: a Randomized Controlled Trial in Males and Females With Vitamin D Deficiency | COMPLETED | INTERVENTIONAL | VD3, omega 3- FA, VD3 and omega- 3FA |
| NCT01232309 | A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of the Effects of Chitin-Glucan on Oxidized Low-Density Lipoprotein (LDL) | COMPLETED | INTERVENTIONAL | Chitin-Glucan, Low Dose Chitin-Glucan, Low Dose Chitin-Glucan + Olive Extract |
Genetic associations (0)
None linked.