B
Plasminogen activator inhibitor-1 (PAI-1)
Hemostatic & ThromboticLab test / biomarkerriskpartially modifiable
30
evidence score
Also known as: PAI-1, PAI-1 (plasminogen activator inhibitor-1), pai-1, plasminogen activator inhibitor, plasminogen activator inhibitor-1 (PAI-1) elevation
PREVENT status
Not a PREVENT input variable.
Causal support
observational only
Score components
lit volume: 17.9meta-analyses: 9.1trials: 3genetic: 0MR bonus:
References (60)
2 meta-analyses / systematic reviews- METAThe roles of PAI-1 gene polymorphisms in atherosclerotic diseases: A systematic review and meta-analysis involving 149,908 subjects. — Gene 2018 · PMID 29908999
- METAModerate alcohol consumption and atherosclerosis : Meta-analysis of effects on lipids and inflammation. — Wiener klinische Wochenschrift 2017 · PMID 28762059
- Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity. — Cell metabolism 2024 · PMID 38569471
- Metabolic Changes Induced by Bariatric Surgery May be Mediated by PAI-1 and PCSK9 Crosstalk. — Archives of medical research 2024 · PMID 38971127
- Similar Pathophysiological Mechanisms Between Osteoarthritis and Vascular Disease. — Frontiers in bioscience (Landmark edition) 2024 · PMID 39344315
- JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study. — European heart journal 2023 · PMID 36469488
- Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes. — Science (New York, N.Y.) 2023 · PMID 37651538
- The Antiobesity Effects and Potential Mechanisms of. — Journal of medicinal food 2023 · PMID 38060708
- PAI-1: A Major Player in the Vascular Dysfunction in Obstructive Sleep Apnea? — International journal of molecular sciences 2022 · PMID 35628326
- Gut Microbiota and Coronary Plaque Characteristics. — Journal of the American Heart Association 2022 · PMID 36000423
- Biomarkers associated with coronary high-risk plaques. — Journal of thrombosis and thrombolysis 2022 · PMID 36205839
- LDR-adapted liver-derived cytokines have potential to induce atherosclerosis. — International journal of radiation biology 2022 · PMID 36383216
- Correlation between serum Dickkopf-1 (DKK1) levels and coronary artery stenosis. — Nutrition, metabolism, and cardiovascular diseases : NMCD 2022 · PMID 36411225
- Psoriasis and Diabetes, a Dangerous Association: Evaluation of Insulin Resistance, Lipid Abnormalities, and Cardiovascular Risk Biomarkers — Frontiers in Medicine 2021 · PMID 33834030
- Circulating Biomarkers for Cardiovascular Disease Risk Prediction in Patients With Cardiovascular Disease — Frontiers in Cardiovascular Medicine 2021 · PMID 34660715
- Vasculoprotective Effects of Vildagliptin. Focus on Atherogenesis. — International journal of molecular sciences 2020 · PMID 32218354
- Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome. — Arteriosclerosis, thrombosis, and vascular biology 2020 · PMID 32268785
- Thrombosis in Coronavirus disease 2019 (COVID-19) through the prism of Virchow's triad. — Clinical rheumatology 2020 · PMID 32654082
- Single-Cell Transcriptomic Profiling of Vascular Smooth Muscle Cell Phenotype Modulation in Marfan Syndrome Aortic Aneurysm. — Arteriosclerosis, thrombosis, and vascular biology 2020 · PMID 32698686
- NFAT5 directs hyperosmotic stress-induced fibrin deposition and macrophage infiltration via PAI-1 in endothelium. — Aging 2020 · PMID 33410782
- Role of parnaparin in atherosclerosis. — International journal of experimental pathology 2017 · PMID 28205266
- The genetic basis of obesity complications. — Acta scientiarum polonorum. Technologia alimentaria 2017 · PMID 28362475
- Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herbvar.. — Frontiers in pharmacology 2017 · PMID 28785222
- PAI-1 levels are related to insulin resistance and carotid atherosclerosis in subjects with familial combined hyperlipidemia. — Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2017 · PMID 28822973
- Small molecules inhibitors of plasminogen activator inhibitor-1 - an overview. — European journal of medicinal chemistry 2015 · PMID 25615797
- Adverse effects of glucocorticoids: coagulopathy. — European journal of endocrinology 2015 · PMID 25971647
- Effect of Weight Loss on the Cardiovascular Risk Profile of Obese Patients with Psoriasis — Acta Dermato Venereologica 2014 · PMID 24556829
- D-dimer predicts major bleeding, cardiovascular events and all-cause mortality during warfarin treatment. — Clinical biochemistry 2014 · PMID 24636802
- Cardiovascular Risk and Psoriasis — Angiology 2014 · PMID 24671131
- Functional stability of plasminogen activator inhibitor-1. — TheScientificWorldJournal 2014 · PMID 25386620
- Plasminogen activator inhibitor-1 in kidney pathology (Review). — International journal of molecular medicine 2013 · PMID 23314920
- Phloretin suppresses thrombin-mediated leukocyte-platelet-endothelial interactions. — Molecular nutrition & food research 2013 · PMID 24338998
- PAI-1, progress in understanding the clinical problem and its aetiology. — British journal of haematology 2012 · PMID 22360729
- Role of fibrinolytic parameters and plasminogen activator inhibitor 1 (PAI-1) promoter polymorphism on premature atherosclerosis in SLE patients. — Lupus 2011 · PMID 21719525
- Plasminogen activator inhibitor-1 (PAI-1): a key factor linking fibrinolysis and age-related subclinical and clinical conditions. — Cardiovascular therapeutics 2010 · PMID 20626406
- Mechanisms of lead-induced hypertension and cardiovascular disease. — American journal of physiology. Heart and circulatory physiology 2008 · PMID 18567711
- Adipose tissue dysfunction in obesity, diabetes, and vascular diseases — European Heart Journal 2008 · PMID 18775919
- The 'PAI-1 paradox' in vascular remodeling. — Thrombosis and haemostasis 2008 · PMID 19132221
- uPAR-uPA-PAI-1 interactions and signaling: a vascular biologist's view. — Thrombosis and haemostasis 2007 · PMID 17334498
- Symptomatic Intracerebral Hemorrhage following Thrombolytic Therapy for Acute Ischemic Stroke: A Review of the Risk Factors — Cerebrovascular Diseases 2007 · PMID 17519538
- Vitamin E: inflammation and atherosclerosis. — Vitamins and hormones 2007 · PMID 17628188
- Diabetes mellitus and macrovascular disease: mechanisms and mediators. — The American journal of medicine 2007 · PMID 17826041
- Serpins, the vasculature, and viral therapeutics. — Frontiers in bioscience : a journal and virtual library 2006 · PMID 16146796
- The metabolic syndrome and cardiovascular disease — Annals of Medicine 2006 · PMID 16448990
- Plasminogen activator system and vascular disease. — Current vascular pharmacology 2006 · PMID 16611153
- Retinal Vascular Caliber, Cardiovascular Risk Factors, and Inflammation: The Multi-Ethnic Study of Atherosclerosis (MESA) — Investigative Ophthalmology & Visual Science 2006 · PMID 16723443
- Cell biology and lipoproteins in atherosclerosis. — Current molecular medicine 2006 · PMID 16918367
- C-reactive protein (CRP)-lowering agents. — Cardiovascular drug reviews 2006 · PMID 16939632
- Hemostasis alterations in metabolic syndrome (review). — International journal of molecular medicine 2006 · PMID 17016629
- Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease — European Heart Journal 2006 · PMID 17056702
- Pleiotropic functions of plasminogen activator inhibitor-1. — Journal of thrombosis and haemostasis : JTH 2005 · PMID 15634264
- Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta. — Arteriosclerosis, thrombosis, and vascular biology 2005 · PMID 15718495
- PAI-1 and atherothrombosis. — Journal of thrombosis and haemostasis : JTH 2005 · PMID 16102055
- Which Hemostatic Markers Add to the Predictive Value of Conventional Risk Factors for Coronary Heart Disease and Ischemic Stroke? — Circulation 2005 · PMID 16286603
- Obstructive sleep apnea and cardiovascular disease. — Mayo Clinic proceedings 2004 · PMID 15301332
- Adipokines: inflammation and the pleiotropic role of white adipose tissue — British Journal Of Nutrition 2004 · PMID 15469638
- Increased oxidative stress in obesity and its impact on metabolic syndrome — Journal of Clinical Investigation 2004 · PMID 15599400
- Anti-inflammatory effects of alpha-tocopherol. — Annals of the New York Academy of Sciences 2004 · PMID 15753145
- Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly. — Cardiovascular research 2004 · PMID 15820196
- Inflammation, insulin resistance, and atherosclerosis. — Metabolic syndrome and related disorders 2004 · PMID 18370641
Clinical trials (1)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT04305171 | Effect of Non-surgical Periodontal Treatment on Plasma Fibrinogen, Plasminogen Activator Inhibitor 1 and C-reactive Protein Levels in Cardiovascular Disease Patients With Periodontitis | COMPLETED | OBSERVATIONAL | non-surgical periodontal treatment |
Genetic associations (0)
None linked.