B
Platelet reactivity/aggregation
Hemostatic & ThromboticLab test / biomarkerriskpartially modifiable
35
evidence score
Also known as: Platelet reactivity, platelet activation, platelet aggregation, platelet reactivity
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 15.3meta-analyses: 6trials: 13.4genetic: 0MR bonus:
References (33)
1 meta-analyses / systematic reviews- METALeptin and coronary heart disease: a systematic review and meta-analysis. — Atherosclerosis 2013 · PMID 24529114
- Cardiovascular disease and microbiome: focus on ischemic stroke. — Polish archives of internal medicine 2025 · PMID 40838552
- Platelet Activation and a Platelet Biosignature Are Associated With Cardiovascular Risk in Patients With Controlled Psoriasis. — Arteriosclerosis, thrombosis, and vascular biology 2025 · PMID 40905118
- Jak2 V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk. — Blood 2024 · PMID 38142422
- Depression and coronary heart disease: mechanisms, interventions, and treatments — Frontiers in Psychiatry 2024 · PMID 38404466
- Xylitol is prothrombotic and associated with cardiovascular risk. — European heart journal 2024 · PMID 38842092
- Gut Microbiota-Derived TMAO: A Causal Factor Promoting Atherosclerotic Cardiovascular Disease? — International journal of molecular sciences 2023 · PMID 36768264
- Atherosclerotic Cardiovascular Disease in Inflammatory Bowel Disease: The Role of Chronic Inflammation and Platelet Aggregation. — Medicina (Kaunas, Lithuania) 2023 · PMID 36984554
- Platelet activation: a promoter for psoriasis and its comorbidity, cardiovascular disease. — Frontiers in immunology 2023 · PMID 37654493
- Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study. — European heart journal 2022 · PMID 35165707
- Arterial stiffness, endothelial dysfunction and impaired fibrinolysis are pathogenic mechanisms contributing to cardiovascular risk in ANCA-associated vasculitis. — Kidney international 2022 · PMID 35998848
- Cardiovascular Risk in Patients With Psoriasis: JACC Review Topic of the Week. — Journal of the American College of Cardiology 2021 · PMID 33795041
- Psoriasis and Cardiovascular Disease: Novel Mechanisms and Evolving Therapeutics. — Current atherosclerosis reports 2021 · PMID 34468875
- A robust and efficient method for Mendelian randomization with hundreds of genetic variants — Nature Communications 2020 · PMID 31953392
- The bidirectional relationship between chronic obstructive pulmonary disease and coronary artery disease. — Herz 2020 · PMID 32052074
- Gut microbiota in atherosclerosis: focus on trimethylamine N‐oxide — Apmis 2020 · PMID 32108960
- A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. — Cell 2020 · PMID 32142679
- Plasma levels of trimethylamine-N-oxide can be increased with ‘healthy’ and ‘unhealthy’ diets and do not correlate with the extent of atherosclerosis but with plaque instability — Cardiovascular Research 2020 · PMID 32267921
- Thrombosis in Coronavirus disease 2019 (COVID-19) through the prism of Virchow's triad. — Clinical rheumatology 2020 · PMID 32654082
- Serum albumin and cardiovascular disease: State-of-the-art review. — Annales de cardiologie et d'angeiologie 2020 · PMID 32797938
- Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation — Oxidative Medicine and Cellular Longevity 2019 · PMID 31354915
- Hemostasis in Allergy. — Seminars in thrombosis and hemostasis 2018 · PMID 29920622
- Novel biomarkers of cardiovascular disease: Applications in clinical practice — Critical Reviews in Clinical Laboratory Sciences 2018 · PMID 30457415
- Cocoa, blood pressure, and cardiovascular health. — Journal of agricultural and food chemistry 2015 · PMID 26125676
- Acute and persistent platelet and coagulant activities in atherothrombosis. — Journal of thrombosis and haemostasis : JTH 2015 · PMID 26149036
- Outdoor particulate matter (PM) and associated cardiovascular diseases in the Middle East. — International journal of occupational medicine and environmental health 2015 · PMID 26216305
- Infectious burden: a new risk factor and treatment target for atherosclerosis. — Infectious disorders drug targets 2010 · PMID 20166973
- Acute coronary syndrome and its antithrombotic treatment: focus on aspirin and clopidogrel resistance. — Current vascular pharmacology 2009 · PMID 19356003
- Depression and heart disease: therapeutic implications. — Cardiology 2008 · PMID 18376116
- Treatment of depression in patients with coronary heart disease. — The American journal of medicine 2006 · PMID 16828625
- C-reactive protein (CRP)-lowering agents. — Cardiovascular drug reviews 2006 · PMID 16939632
- Associations Between Soluble CD40 Ligand, Atherosclerosis Risk Factors, and Subclinical Atherosclerosis — Arteriosclerosis Thrombosis and Vascular Biology 2005 · PMID 16109925
- Depression as a risk factor for coronary artery disease: evidence, mechanisms, and treatment. — Psychosomatic medicine 2004 · PMID 15184688
Clinical trials (21)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07644234 | Platelet Aggregation Function-Guided De-Escalation Antiplatelet Therapy in Patients With Acute Ischemic Stroke | NOT YET RECRUITING | INTERVENTIONAL | Clopidogrel, Aspirin |
| NCT05903976 | De-Escalation of Antiplatelet Therapy to Evaluate Platelet Reactivity and Clinical Outcomes After Coronary Stenting in Patients at High Bleeding Risk and Recent Acute Coronary Syndrome: DESC-HBR Trial | UNKNOWN | INTERVENTIONAL | P2Y12 inhibitor de-escalation |
| NCT07597239 | The Use of Thromboelastography With Platelet Mapping to Guide Thromboprophylaxis Following Lower Extremity Revascularization for Peripheral Artery Disease | ACTIVE NOT RECRUITING | INTERVENTIONAL | Aspirin, Clopidogrel, Ticagrelor |
| NCT05956145 | Effect of Low Dose of Colchicine on Platelet Reactivty in Patients With Chronic Coronary Disease | COMPLETED | INTERVENTIONAL | Colchicine 0.5 MG, Placebo |
| NCT03331666 | Impact of LDL-cholesterol Lowering on Platelet Activation | TERMINATED | INTERVENTIONAL | Evolocumab |
| NCT03679091 | Low-dose of Ticagrelor and Standard-dose Clopidogrel on Platelet Effects in Chinese Patients With Stable Coronary Artery Disease: a Randomized, Single-blind, Crossover Clinical Study | COMPLETED | INTERVENTIONAL | low-dose ticagrelor, Clopidogrel |
| NCT03258281 | Effects of Evolocumab on Platelet Reactivity in Patients With Diabetes Mellitus After Elective Percutaneous Coronary Intervention | TERMINATED | INTERVENTIONAL | Evolocumab, Placebo |
| NCT03096288 | Impact of the PCSK9 Inhibitor Evolocumab on the Pharmacodynamic Effects of Clopidogrel in Patients With Atherosclerotic Cardiovascular Disease and High On-Treatment Platelet Reactivity | COMPLETED | INTERVENTIONAL | Evolocumab, Placebo |
| NCT03062462 | Half-dose Ticagrelor Overcomes High-dose Clopidogrel in Acute Coronary Syndrome Patients With High On-Clopidogrel Platelet Reactivity | UNKNOWN | INTERVENTIONAL | Clopidogrel, ticagrelor |
| NCT01739556 | On-treatment PLAtelet Reactivity-guided Therapy Modification FOR ST-segment Elevation Myocardial Infarction (PLATFORM) | TERMINATED | INTERVENTIONAL | Antiplatelet Regimen Modification (aspirin or ticagrelor) |
| NCT02319941 | Comparison of Low-Dose, Standard-Dose Ticagrelor and Clopidogrel for Inhibition of Platelet Reactivity in Patients With Acute Coronary Syndromes; Pharmacodynamics and Pharmacokinetics Study | COMPLETED | INTERVENTIONAL | ticagrelor, clopidogrel |
| NCT02030054 | Pharmacodynamic Comparison of Rosuvastatin Versus Atorvastatin on Platelet Reactivity in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With New P2Y12 Inhibitors | UNKNOWN | INTERVENTIONAL | Atorvastatin, Rosuvastatin |
| NCT05293808 | Evaluation of Different Doses of Aspirin on Platelet Aggregation in Diabetic Patients With Acute Coronary Syndrome | COMPLETED | INTERVENTIONAL | aspirin 100 mg bis in die, aspririn 200 mg once daily, aspirin 100 mg once daily |
| NCT02178501 | The Effect of Omega-3 Polyunsaturated Acids Supplementation on Endothelial Function, Oxidative Stress, Platelet Aggregation, Blood Coagulation and Inflammation in Patients With Type 2 Diabetes and Cardiovascular Disease | COMPLETED | INTERVENTIONAL | Omega-3 PUFA |
| NCT01567774 | Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on pLatelet Reactivity in Stable Patients With Coronary Artery Disease Treated With Dual Antiplatelet Therapy | UNKNOWN | INTERVENTIONAL | Atorvastatin, Rosuvastatin |
| NCT01463163 | Ticagrelor in Comparison to Prasugrel for Early Inhibition of Platelet Reactivity in Patients With ST-elevation Myocardial Infarction (STEMI), Undergoing Primary Percutaneous Coronary Intervention (PCI) | COMPLETED | INTERVENTIONAL | Prasugrel, Ticagrelor |
| NCT01465828 | PhaRmacodynamic Effects of Switching thErapy in paTients With High on Treatment Platelet Reactivity and Genotype Variation: High Clopidogrel Dose Versus Prasugrel RESET GENE Trial | COMPLETED | INTERVENTIONAL | Clopidogrel, prasugrel |
| NCT00466401 | Phase 4 Study on Effect of Ezetimibe on Platelet Aggregation and LDL Tendency to Peroxidation In Hypercholesterolemic Patients on Simvastatin | COMPLETED | INTERVENTIONAL | Simvastatin, Ezetimibe |
| NCT00325390 | Double-Blind Parallel Comparison Study of SR25990C Versus Standard Therapy in Japan(Ticlopidine) in Patients With Acute Coronary Syndrome Without ST-Segment Elevation Who Are Planned for Percutaneous Coronary Intervention | COMPLETED | INTERVENTIONAL | clopidogrel (SR25990C) |
| NCT04165629 | Influence of Platelet Reactivity in Peripheral Arterial Disease Patients Undergoing Percutaneous Angioplasty on Mid-term Outcomes | UNKNOWN | OBSERVATIONAL | Aspirin 300mg and Clopidogrel 300mg |
| NCT01449617 | Observational Study on Predictive Value for Vascular Events of Residual Platelet Aggregation in Patients on Antiplatelet Therapy After Carotid Angioplasty With Stenting | UNKNOWN | OBSERVATIONAL | Aspirin plus clopidogrel |
Genetic associations (0)
None linked.