B
Polygenic risk score
Genetic & Family HistoryGenetic / heritablerisknon modifiable
48
evidence score
Also known as: genetic risk score, polygenic score, prs
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 20meta-analyses: 0trials: 7.8genetic: 20MR bonus:
Associated genes
CDKN2B-AS1LPAPHACTR1HDAC9CELSR2TWIST1LINC01438ABOSMARCA4APOEATXN2LDLRCOL4A2TARIDY_RNA
References (100)
0 meta-analyses / systematic reviews- Polygenic risk score, dietary inflammatory potential, and incident coronary heart disease. — European journal of preventive cardiology 2025 · PMID 39881513
- Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease: A clinical consensus statement of the ESC Council on Cardiovascular Genomics, the ESC Cardiovascular Risk Collaboration, and the European Association of Preventive Cardiology. — European heart journal 2025 · PMID 39906985
- Polygenic risk score for coronary artery disease predicts atherosclerotic cardiovascular disease in familial hypercholesterolemia. — Journal of clinical lipidology 2025 · PMID 40000284
- Polygenic Scores of Cardiometabolic Risk Factors in American Indian Adults. — JAMA network open 2025 · PMID 40072435
- Proteomic Signatures for Risk Prediction of Atrial Fibrillation. — Circulation 2025 · PMID 40401370
- Importance of Clinical, Laboratory, and Genetic Risk Factors for Incident CAD. — Circulation. Genomic and precision medicine 2025 · PMID 40605734
- Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases. — Nature biotechnology 2025 · PMID 40715455
- Genetic insights into lipid traits and atherosclerosis risk: a Mendelian randomization and polygenic risk score analysis. — International journal of surgery (London, England) 2025 · PMID 40793967
- Prospective associations of obesity heterogeneity, serum proteins, and carotid atherosclerosis risk. — EBioMedicine 2025 · PMID 40975927
- Insulin resistance-related indices, genetic risk, and the risk of cardiovascular disease in individuals with preclinical or clinical obesity: a large prospective cohort study in the UK biobank. — Cardiovascular diabetology 2025 · PMID 41139206
- Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease. — Journal of the American Heart Association 2025 · PMID 41368830
- Improved sex-specific cardiovascular risk prediction with multi-omics data in people with type 2 diabetes. — Cardiovascular diabetology 2025 · PMID 41444601
- Associations of combined polygenic risk score and glycemic status with atrial fibrillation, coronary artery disease and ischemic stroke — Cardiovascular Diabetology 2024 · PMID 38172896
- Somatic and Germline Variants and Coronary Heart Disease in a Chinese Population. — JAMA cardiology 2024 · PMID 38198131
- Novel Polygenic Risk Score and Established Clinical Risk Factors for Risk Estimation of Aortic Stenosis. — JAMA cardiology 2024 · PMID 38416462
- Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease. — European journal of preventive cardiology 2024 · PMID 38437179
- Association between BMD and coronary artery calcification: an observational and Mendelian randomization study. — Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 · PMID 38477752
- Cardiovascular Significance and Genetics of Epicardial and Pericardial Adiposity. — JAMA cardiology 2024 · PMID 38477908
- Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases. — Cell genomics 2024 · PMID 38508198
- Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease. — European heart journal 2024 · PMID 38551411
- Changes in Sleep Patterns, Genetic Susceptibility, and Incident Cardiovascular Disease in China. — JAMA network open 2024 · PMID 38652473
- Intrinsic Capacity, Polygenic Risk Score,Genotype, and Risk of Dementia: A Prospective Cohort Study Based on the UK Biobank. — Neurology 2024 · PMID 38843484
- Polygenic risk score adds to a clinical risk score in the prediction of cardiovascular disease in a clinical setting. — European heart journal 2024 · PMID 38848106
- Artificial sweeteners and risk of incident cardiovascular disease and mortality: evidence from UK Biobank. — Cardiovascular diabetology 2024 · PMID 38965574
- Associations of metabolic changes and polygenic risk scores with cardiovascular outcomes and all-cause mortality across BMI categories: a prospective cohort study. — Cardiovascular diabetology 2024 · PMID 38965592
- Joint impact of polygenic risk score and lifestyles on early- and late-onset cardiovascular diseases. — Nature human behaviour 2024 · PMID 38987358
- The risk stratification and predictive performance of a new combined polygenic risk score for hepatocellular carcinoma. — Journal of gastroenterology 2024 · PMID 39126459
- Cardiovascular health, polygenic risk score, and cancer risk: a prospective cohort study. — The American journal of clinical nutrition 2024 · PMID 39134210
- A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release. — PloS one 2024 · PMID 39292644
- Dietary Antioxidant Capacity, Genetic Susceptibility and Polymorphism, and Inflammatory Bowel Disease Risk in a Prospective Cohort. — Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2024 · PMID 39510220
- Combined Effect of Air Pollution and Genetic Risk on Incident Cardiovascular Diseases. — Journal of the American Heart Association 2024 · PMID 39547964
- Polygenic Risk Score and Lung Adenocarcinoma Risk Among Never-Smokers by EGFR Mutation Status: A Brief Report. — Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2024 · PMID 39581378
- Exploring the Genetic Relationship Between Type 2 Diabetes and Cardiovascular Disease: A Large-Scale Genetic Association and Polygenic Risk Score Study. — Biomolecules 2024 · PMID 39595643
- Development and Evaluation of a Comprehensive Prediction Model for Incident Coronary Heart Disease Using Genetic, Social, and Lifestyle-Psychological Factors: A Prospective Analysis of the UK Biobank. — Annals of internal medicine 2024 · PMID 39652873
- Large-Scale Plasma Proteomics Profiles for Predicting Ischemic Stroke Risk in the General Population. — Stroke 2024 · PMID 39704077
- A polygenic risk score predicts atrial fibrillation in cardiovascular disease. — European heart journal 2023 · PMID 35980763
- Association of Social Isolation and Loneliness With Incident Heart Failure in a Population-Based Cohort Study. — JACC. Heart failure 2023 · PMID 36737310
- Genetic and clinical factors underlying a self-reported family history of heart disease. — European journal of preventive cardiology 2023 · PMID 37011137
- Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures. — American journal of human genetics 2023 · PMID 37060905
- Coronary Artery Calcium Score and Polygenic Risk Score for the Prediction of Coronary Heart Disease Events. — JAMA 2023 · PMID 37219552
- Incorporating a polygenic risk score-triaged coronary calcium score into cardiovascular disease examinations to identify subclinical coronary artery disease (ESCALATE): Protocol for a prospective, nonrandomized implementation trial — American Heart Journal 2023 · PMID 37364748
- A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease — Nature Medicine 2023 · PMID 37414900
- Evaluation of Large-Scale Proteomics for Prediction of Cardiovascular Events. — JAMA 2023 · PMID 37606673
- Genetically predicted waist-to-hip circumference ratio and coronary artery disease: A sex-specific Mendelian randomization study. — HGG advances 2023 · PMID 37663544
- Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog — BMJ Medicine 2023 · PMID 37859783
- Adherence to a healthy lifestyle, genetic susceptibility to abdominal obesity, cardiometabolic risk markers, and risk of coronary heart disease. — The American journal of clinical nutrition 2023 · PMID 37923500
- Polygenic Risk Score for Cardiovascular Diseases in Artificial Intelligence Paradigm: A Review. — Journal of Korean medical science 2023 · PMID 38013648
- UK Biobank release and systematic evaluation of optimised polygenic risk scores for 53 diseases and quantitative traits — medRxiv 2022
- American Heart Association’s Life’s Simple 7: Lifestyle Recommendations, Polygenic Risk, and Lifetime Risk of Coronary Heart Disease — Circulation 2022 · PMID 35094551
- A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study. — European heart journal 2022 · PMID 35195259
- Development of a clinical polygenic risk score assay and reporting workflow — Nature Medicine 2022 · PMID 35437332
- Genome-wide and phenome-wide analysis of ideal cardiovascular health in the VA Million Veteran Program. — PloS one 2022 · PMID 35613103
- Integrating a Polygenic Risk Score for Coronary Artery Disease as a Risk‐Enhancing Factor in the Pooled Cohort Equation: A Cost‐Effectiveness Analysis Study — Journal of the American Heart Association 2022 · PMID 35699184
- Contribution of Genome-Wide Polygenic Score to Risk of Coronary Artery Disease in Childhood Cancer Survivors — JACC CardioOncology 2022 · PMID 35818558
- Pathway-Specific Polygenic Risk Scores Identify Obstructive Sleep Apnea–Related Pathways Differentially Moderating Genetic Susceptibility to Coronary Artery Disease — Circulation Genomic and Precision Medicine 2022 · PMID 36170352
- Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses — Circulation 2022 · PMID 36314129
- Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular Events. — Circulation. Genomic and precision medicine 2022 · PMID 36334310
- Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease — BMC Medicine 2022 · PMID 36336692
- Systematic comparison of family history and polygenic risk across 24 common diseases — The American Journal of Human Genetics 2022 · PMID 36347255
- Polygenic risk score and age: an extra help in the cardiovascular prevention of the young? — European heart journal supplements : journal of the European Society of Cardiology 2022 · PMID 36380786
- Polygenic risk scores for the prediction of cardiometabolic disease — European Heart Journal 2022 · PMID 36478054
- Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention — JAMA Cardiology 2022 · PMID 36576811
- Interactions Between Enhanced Polygenic Risk Scores and Lifestyle for Cardiovascular Disease, Diabetes, and Lipid Levels — Circulation Genomic and Precision Medicine 2021 · PMID 33433237
- Cardiovascular risk factor mediation of the effects of education and Genetic Risk Score on cardiovascular disease: a prospective observational cohort study of the Framingham Heart Study. — BMJ open 2021 · PMID 33436477
- Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease — Genome Medicine 2021 · PMID 33441150
- Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction — Circulation Genomic and Precision Medicine 2021 · PMID 33651632
- Development and Validation of a Polygenic Risk Score for Stroke in the Chinese Population. — Neurology 2021 · PMID 34031205
- Polygenic Risk Score–Enhanced Risk Stratification of Coronary Artery Disease in Patients With Stable Chest Pain — Circulation Genomic and Precision Medicine 2021 · PMID 34032468
- Coronary Artery Disease–Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort Study — Clinical Infectious Diseases 2021 · PMID 34091660
- Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study. — Clinical nutrition (Edinburgh, Scotland) 2021 · PMID 34237696
- Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men — Circulation Genomic and Precision Medicine 2021 · PMID 34670400
- Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region. — JACC. Asia 2021 · PMID 36341217
- Polygenic Hyperlipidemias and Coronary Artery Disease Risk — UTUPub (University of Turku) 2020
- Polygenic risk scores outperform machine learning methods in predicting coronary artery disease status — Genetic Epidemiology 2020 · PMID 31922285
- Association of Monogenic vs Polygenic Hypercholesterolemia With Risk of Atherosclerotic Cardiovascular Disease — JAMA Cardiology 2020 · PMID 32049305
- Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease — JAMA 2020 · PMID 32068817
- Predictive Accuracy of a Polygenic Risk Score–Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease — JAMA 2020 · PMID 32068818
- Polygenic risk scores for coronary artery disease and subsequent event risk amongst established cases — Human Molecular Genetics 2020 · PMID 32219344
- Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease — Arteriosclerosis Thrombosis and Vascular Biology 2020 · PMID 32957805
- A Journey through Genetic Architecture and Predisposition of Coronary Artery Disease. — Current genomics 2020 · PMID 33093801
- Population Bias in Polygenic Risk Prediction Models for Coronary Artery Disease — Circulation Genomic and Precision Medicine 2020 · PMID 33170024
- Validation of genome-wide polygenic risk scores for coronary artery disease in French Canadians — bioRxiv (Cold Spring Harbor Laboratory) 2019
- Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort. — Molecular psychiatry 2019 · PMID 30886334
- Polygenic prediction via Bayesian regression and continuous shrinkage priors — Nature Communications 2019 · PMID 30992449
- Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians — Circulation Genomic and Precision Medicine 2019 · PMID 31184202
- Analysis of polygenic risk score usage and performance in diverse human populations — Nature Communications 2019 · PMID 31346163
- Towards clinical utility of polygenic risk scores — Human Molecular Genetics 2019 · PMID 31363735
- Patients With High Genome-Wide Polygenic Risk Scores for Coronary Artery Disease May Receive Greater Clinical Benefit From Alirocumab Treatment in the ODYSSEY OUTCOMES Trial — Circulation 2019 · PMID 31707832
- Psoriasis, cardiovascular risk factors and metabolic disorders: sex‐specific findings of a population‐based study — Journal of the European Academy of Dermatology and Venereology 2019 · PMID 31797464
- Polygenic Risk Scores in Coronary Artery Disease and Atrial Fibrillation. — Heart, lung & circulation 2019 · PMID 31974023
- Polygenic Contribution in Individuals With Early-Onset Coronary Artery Disease — Circulation Genomic and Precision Medicine 2018 · PMID 29874178
- Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults — Journal of the American College of Cardiology 2018 · PMID 30309464
- Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease. — JAMA 2017 · PMID 28196256
- Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting — Circulation 2017 · PMID 28223407
- Interrelation of Cadmium, Smoking, and Cardiovascular Disease (from the National Health and Nutrition Examination Survey). — The American journal of cardiology 2016 · PMID 27316775
- Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease — New England Journal of Medicine 2016 · PMID 27959714
- Uric Acid and Cardiovascular Events — Journal of the American Society of Nephrology 2015 · PMID 25788527
- Correction: Power and Predictive Accuracy of Polygenic Risk Scores — PLoS Genetics 2013
- Power and Predictive Accuracy of Polygenic Risk Scores — PLoS Genetics 2013 · PMID 23555274
- A Genetic Risk Score Is Associated With Incident Cardiovascular Disease and Coronary Artery Calcium — Circulation Cardiovascular Genetics 2012 · PMID 22235037
Clinical trials (5)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07087431 | PROACT 3: Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health | RECRUITING | INTERVENTIONAL | Immediate disclosure of CAD PRS results, Deferred Disclosure of CAD PRS results |
| NCT06962488 | Clinical Implementation of Blood Pressure Polygenic Risk Score | RECRUITING | INTERVENTIONAL | Regular Care, SBP PRS Dissemination |
| NCT06911294 | Feasibility of InnovaTive Approaches for Personalized Cardiovascular PREVention: Randomized Controlled Pilot Trial and Multidisciplinary Evaluation for National Health Service Implementation | RECRUITING | INTERVENTIONAL | Polygenic Risk Score, Digital app and wearable device |
| NCT04604353 | Early Detection of Coronary Artery Disease by Polygenic and Metabolic Risk Scoring in at Risk Patients: Comparison With Coronary Computed Tomography | COMPLETED | INTERVENTIONAL | Polygenic Risk Score, Coronary Calcium Score |
| NCT05169840 | Genetic Risk Stratification for Primary Prevention of CAD in Men and Pre & Post-menopausal Women | UNKNOWN | OBSERVATIONAL | Genetic Risk Score for Coronary Artery Disease |
Genetic associations (2742)
showing top 80 by significance| Variant | Gene(s) | Trait | p | OR/β | Study |
|---|---|---|---|---|---|
| rs10901252 | ABO | coronary artery disorder | 1e-324 | — | GCST90129544 |
| rs687621 | ABO | coronary artery disorder | 1e-324 | — | GCST90129543 |
| rs1046205 | MCF2L | coronary artery disorder | 1e-324 | — | GCST90129542 |
| rs1046205 | MCF2L | Ischemic stroke | 1e-324 | — | GCST90129549 |
| rs10793962 | ABO | Ischemic stroke | 1e-324 | — | GCST90129551 |
| rs116552240 | ABO | Ischemic stroke | 1e-324 | — | GCST90129550 |
| rs710446 | KNG1, HRG-AS1 | Ischemic stroke | 1e-307 | — | GCST90129552 |
| rs75331444 | ABCG8 | coronary artery disorder | 1e-300 | — | GCST90428732 |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-300 | — | GCST90451698 |
| rs56266464 | ABCG5 | stroke disorder | 1e-300 | — | GCST90428731 |
| chr9:22093299 | coronary atherosclerosis | 1e-300 | 0.1686 unit decrease | GCST90475936 | |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-295 | 0.177893 unit increase | GCST010866 |
| rs710446 | KNG1, HRG-AS1 | coronary artery disorder | 1e-294 | — | GCST90129545 |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-278 | 0.84 | GCST90132314 |
| rs102275 | TMEM258 | coronary artery calcification | 1e-264 | — | GCST001639 |
| chr9:22093299 | coronary artery disorder | 1e-260 | 0.1524 unit decrease | GCST90475929 | |
| rs4299376 | ABCG8 | coronary artery disorder | 1e-238 | — | GCST90428732 |
| rs17042098 | PITX2, LINC01438 | cardioembolic stroke | 1e-237 | 32.86 z score increase | GCST90132228 |
| rs10455872 | LPA | coronary atherosclerosis | 1e-234 | 0.2816 unit decrease | GCST90475936 |
| rs4977574 | CDKN2B-AS1 | coronary artery disorder | 1e-223 | 0.1788 unit decrease | GCST005195 |
| rs35519679 | TCF7L2 | coronary artery disorder | 1e-218 | — | GCST90451699 |
| rs10455872 | LPA | coronary artery disorder | 1e-204 | 0.256 unit decrease | GCST90475929 |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-204 | 0.189 unit decrease | GCST005194 |
| rs4253417 | F11 | Ischemic stroke | 1e-197 | — | GCST90129552 |
| rs1333049 | CDKN2B-AS1 | coronary artery disorder | 1e-192 | 0.1879 unit increase | GCST005196 |
| rs4253417 | F11 | coronary artery disorder | 1e-189 | — | GCST90129545 |
| rs2227402 | FGB | Ischemic stroke | 1e-189 | — | GCST90129553 |
| rs10455872 | LPA | coronary artery disorder | 1e-186 | 0.738 | GCST90132314 |
| rs55730499 | LPA | coronary artery disorder | 1e-186 | — | GCST90132314 |
| chr9:22093299 | coronary artery disorder | 1e-182 | 0.1908 unit decrease | GCST90475198 | |
| rs2227402 | FGB | coronary artery disorder | 1e-182 | — | GCST90129546 |
| rs1537371 | CDKN2B-AS1 | coronary atherosclerosis | 1e-166 | 0.1568 unit decrease | GCST90480132 |
| rs7598542 | ABCG8 | coronary artery disorder | 1e-161 | — | GCST90428732 |
| rs1537372 | CDKN2B-AS1 | coronary artery disorder | 1e-158 | — | GCST90129546 |
| rs13427362 | ABCG5 | coronary artery disorder | 1e-157 | — | GCST90428732 |
| rs1537372 | CDKN2B-AS1 | coronary artery disorder | 1e-155 | — | GCST90129544 |
| rs1537372 | CDKN2B-AS1 | coronary artery disorder | 1e-155 | — | GCST90129543 |
| rs1537372 | CDKN2B-AS1 | coronary artery disorder | 1e-155 | — | GCST90129542 |
| rs1537372 | CDKN2B-AS1 | coronary artery disorder | 1e-154 | — | GCST90129545 |
| rs55730499 | LPA | coronary artery disorder | 1e-154 | 0.337 unit increase | GCST005194 |
| rs55730499 | LPA | coronary artery disorder | 1e-154 | 0.3368 unit increase | GCST005196 |
| rs55730499 | LPA | coronary artery disorder | 1e-153 | 0.3122 unit increase | GCST005195 |
| rs247617 | CETP, HERPUD1 | coronary artery disorder | 1e-149 | — | GCST004045 |
| rs10455872 | LPA | coronary artery disorder | 1e-148 | 0.3173 unit decrease | GCST90475198 |
| chr9:22093299 | coronary artery disorder | 1e-143 | 0.1827 unit decrease | GCST90475199 | |
| rs2891168 | CDKN2B-AS1 | myocardial infarction | 1e-141 | 1.21 | GCST011365 |
| rs1537371 | CDKN2B-AS1 | coronary artery disorder | 1e-139 | 0.1383 unit decrease | GCST90480134 |
| rs6025 | F5 | Ischemic stroke | 1e-137 | 2.927 | GCST003390 |
| rs10455872 | LPA | coronary atherosclerosis | 1e-134 | 0.279 unit decrease | GCST90480132 |
| rs1333042 | CDKN2B-AS1 | coronary artery disorder | 1e-129 | 0.1814 unit decrease | GCST90479543 |
| rs4977574 | CDKN2B-AS1 | myocardial infarction | 1e-128 | 0.8381 | GCST90432175 |
| rs55730499 | LPA | coronary artery disorder | 1e-124 | — | GCST90129546 |
| rs55730499 | LPA | coronary artery disorder | 1e-122 | — | GCST90129544 |
| rs55730499 | LPA | coronary artery disorder | 1e-122 | — | GCST90129543 |
| rs55730499 | LPA | coronary artery disorder | 1e-122 | — | GCST90129542 |
| rs55730499 | LPA | coronary artery disorder | 1e-122 | — | GCST90129545 |
| rs10455872 | LPA | coronary artery disorder | 1e-121 | — | GCST90129547 |
| rs10455872 | LPA | coronary artery disorder | 1e-121 | — | GCST90129548 |
| rs10455872 | LPA | coronary artery disorder | 1e-121 | 0.3078 unit decrease | GCST90475199 |
| rs2891168 | CDKN2B-AS1 | myocardial infarction | 1e-120 | 0.2022 unit increase | GCST90018877 |
| rs10455872 | LPA | coronary artery disorder | 1e-117 | 0.2528 unit decrease | GCST90480134 |
| rs186696265 | LPA, PLG | coronary artery disorder | 1e-116 | 1.677 | GCST90132314 |
| rs9349379 | PHACTR1 | coronary artery disorder | 1e-114 | 0.892 | GCST90132314 |
| rs4977574 | CDKN2B-AS1 | abdominal aortic aneurysm | 1e-114 | 0.182 unit decrease | GCST90432152 |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-111 | 0.06921224 unit increase | GCST90449059 |
| rs10455872 | LPA | coronary artery disorder | 1e-110 | 0.3099 unit decrease | GCST90479543 |
| rs1333042 | CDKN2B-AS1 | coronary artery disorder | 1e-109 | 0.174 unit decrease | GCST90479542 |
| rs964184 | ZPR1 | coronary artery disorder | 1e-108 | — | GCST004045 |
| rs9349379 | PHACTR1 | coronary artery disorder | 1e-104 | 0.110473 unit increase | GCST010866 |
| rs1532085 | ALDH1A2 | coronary artery calcification | 1e-104 | — | GCST001639 |
| rs56393506 | LPA, PLG | coronary artery disorder | 1e-103 | 0.14927 unit increase | GCST010866 |
| chr9:22093299 | myocardial infarction | 1e-103 | 0.1574 unit decrease | GCST90475932 | |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-101 | 1.19 | GCST004787 |
| rs671 | ALDH2 | myocardial infarction | 1e-101 | 0.3344 unit increase | GCST90018877 |
| rs671 | ALDH2 | myocardial infarction | 1e-101 | 0.33438632 unit increase | GCST90018657 |
| rs10455872 | LPA | coronary artery disorder | 1e-98 | 0.3031 unit decrease | GCST90479542 |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-98 | 1.21 | GCST003116 |
| chr9:22093299 | myocardial infarction | 1e-98 | 0.1589 unit decrease | GCST90475211 | |
| rs9349379 | PHACTR1 | coronary atherosclerosis | 1e-96 | 0.09356 unit decrease | GCST90475936 |
| rs10455872 | LPA | myocardial infarction | 1e-94 | 0.273 unit decrease | GCST90475932 |