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Prediabetes

Glycemic & MetabolicDisease / conditionriskmodifiable
50
evidence score

Also known as: impaired glucose tolerance, pre-diabetes

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 18.8meta-analyses: 15.8trials: 15genetic: 0MR bonus:

References (75)

5 meta-analyses / systematic reviews

Clinical trials (34)

NCTTitleStatusTypeInterventions
NCT06988462Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" FoodRECRUITINGINTERVENTIONALBottarga, Comparator
NCT06693934Jockey Club Precision Prevention Programme on Young Onset DiabetesRECRUITINGINTERVENTIONALRisk assessment with biogenetic and clinical test to predict diabetes risk, Oral glucose tolerance test (OGTT) and cardiovascular-kidney-metabolic (CKM) risk factors, Medication
NCT06446531Pioneering and Affordable Strategies to Prevent Progression of Prediabetes, Obesity and CV Risk in HispanicsRECRUITINGINTERVENTIONALPlacebo, Rybelsus Tablet, Jardiance 25Mg Tablet
NCT06112418A Randomized Comparison of Cleerly Coronary Artery Disease Stage-Based Care Versus Risk Factor-Based Care for Primary Prevention of Cardiovascular EventsRECRUITINGINTERVENTIONALThe Cleerly CAD Staging System
NCT06055036Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health InterventionRECRUITINGINTERVENTIONALBlack Impact Intervention
NCT05844644An Open Label Study Evaluating the Effects of the GOLO for Life® Plan With Release Supplement on Glycemic Control and Weight in Overweight and Obese Adults With Prediabetes or Type 2 DiabetesRECRUITINGINTERVENTIONALRelease
NCT02915198CSP #2002 - Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes (VA-IMPACT)RECRUITINGINTERVENTIONALMetformin XR, Placebo
NCT07609290Effects of Exercise Snacks on Clinical and Health Outcomes in Sedentary Populations With Chronic DiseasesNOT YET RECRUITINGINTERVENTIONALExercise Snacks
NCT07209527Evaluation of Truway Health-Sourced Portable Diagnostic Devices for Early Detection of Chronic Conditions in Outpatient Primary Care Settings: A Prospective Interventional StudyENROLLING BY INVITATIONINTERVENTIONALTruway Portable Ultrasound Device, Truway Blood Glucose Monitor, Standard Oral Hypoglycemic Agent
NCT06448130Effect of Henagliflozin on the Remission of Prediabetes Population: A National Multicenter, Randomized Controlled StudyNOT YET RECRUITINGINTERVENTIONALHenagliflozin 5mg, Henagliflozin 10mg, Placebo
NCT05560971The Effect of Palmitoleic Acid (POA) Supplementation on Insulin Sensitivity and Lipogenesis in Overweight and Obese IndividualsACTIVE NOT RECRUITINGINTERVENTIONALPalmitoleic acid, Placebo
NCT05174507Empagliflozin and Anakinra for the Treatment of Postprandial Hypoglycemia in Patients With Prediabetes: a Randomized, Placebo-controlled StudyWITHDRAWNINTERVENTIONALempagliflozin, anakinra, saline subcutaneous (s.c.) (placebo)
NCT05095038A Six Month Randomized Placebo-controlled Trial of Appethyl® vs Placebo in Management of Pre-diabetes on Overweight and Obese IndividualsTERMINATEDINTERVENTIONALAppethyl®, Placebo
NCT05193578Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related PrediabetesCOMPLETEDINTERVENTIONALSemaglutide, 1.34 mg/mL, Placebo
NCT05182970The Myocardial Infarction and New Treatment With Metformin Study (MIMET) - a R-RCT to Study Metformin and the Prevention of Cardiovascular Events in Patients With Acute Myocardial Infarction and Newly Detected PrediabetesUNKNOWNINTERVENTIONALMetformin
NCT04907214The Effect of SGLT2 Inhibition on Adipose Tissue Inflammation and Endothelial Function PilotCOMPLETEDINTERVENTIONALEmpagliflozin 25 MG
NCT05273840Effect of Nutritional Supplements (Ivital Control) on Clinical Outcomes in Patients With Prediabetes and Obesity：a Randomized Controlled StudyUNKNOWNINTERVENTIONALIvital Control, lifestyle intervention
NCT03101930Cardiovascular Effects of GLP-1 Receptor ActivationCOMPLETEDINTERVENTIONALLiraglutide, Sitagliptin, hypocaloric diet
NCT01926457Treating Prediabetes in the First Trimester: A Randomized Controlled TrialCOMPLETEDINTERVENTIONALTreatment of Prediabetes
NCT01972542The Usefulness of Postprandial Triglyceride for Assessment of Cardiovascular Risk in Healthy People, Impaired Glucose Tolerance and Type 2 DiabetesCOMPLETEDINTERVENTIONALOral fat tolerance test
NCT01642355Investigation of Motivational Interviewing and Prevention Consults to Achieve Cardiovascular TargetsCOMPLETEDINTERVENTIONALPrevention Consult, Consult & Behavioral Intervention
NCT01680211Efficacy and Safety Study of Herbal Supplements (SR-L-01, SR-B-01 and SI-S-01) in the Management of Prediabetes and Mild to Moderate HyperlipidemiaCOMPLETEDINTERVENTIONALSalacia bark extract, Salacia leaf extract, Sesame seed extract
NCT01895387Replacing With Whole Grains and Legumes Reduces Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activities in Plasma and Peripheral Blood Mononuclear Cells in Patients With Prediabetes or Newly Diagnosed Type 2 DiabetesCOMPLETEDINTERVENTIONALDietary intervention-whole grains and legumes, Dietary intervention-Refined rice
NCT01876992Pilot Study of Metformin-induced CBP Phosphorylation at the Cellular Level and Corresponding Clinical Dose Response in Adults and ChildrenTERMINATEDINTERVENTIONALMetformin
NCT01068860A Multi-center, Double-blind, Placebo-controlled, Randomized Study to Compare the Effect of a Subcutaneous Canakinumab Administration to Placebo in Patients With Impaired Glucose Tolerance or Patients With Type 2 Diabetes Treated With Differing Baseline Diabetes TherapiesCOMPLETEDINTERVENTIONALCanakinumab 150 mg, Placebo to Canakinumab
NCT00876928Effect of Vitamin D Supplementation on Pre-Diabetes in a Minority PopulationCOMPLETEDINTERVENTIONALvitamin D, placebo
NCT00122447CVD Risk and Prevention in Early Glucose IntoleranceCOMPLETEDINTERVENTIONALAspirin, Alpha lipoic acid, Olmesartan
NCT00097786A Multinational, Randomized, Double-blind, Placebo-controlled, Forced-titration, 2 x 2 Factorial Design Study of the Efficacy and Safety of Long-term Administration of Nateglinide and Valsartan in the Prevention of Diabetes and Cardiovascular Outcomes in Subjects With Impaired Glucose Tolerance (IGT)COMPLETEDINTERVENTIONALValsartan 160 mg + nateglinide 60 mg, Valsartan 160 mg + nateglinide placebo, Nateglinide 60 mg + valsartan placebo
NCT07602023Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.RECRUITINGOBSERVATIONALOral Fat Load Test
NCT07279922The Role of Triglyceride-glucose Index as a Predictive Marker for Insulin Resistance in Pre Diabetic Chronic Kidney Disease Patients.NOT YET RECRUITINGOBSERVATIONALTriglyceride-glucose index
NCT04475380Complex All-comers and Patients With Diabetes or Prediabetes, Treated With Xience Sierra Everolimus-eluting Stents (COASTLINE)COMPLETEDOBSERVATIONALPercutaneous coronary intervention
NCT04094194Relation of the Nordic Dietary Pattern With Cardiometabolic Risk Factors and Incident Cardiovascular Outcomes: A Systematic Review and Meta-analysis of Randomized Controlled Trials and Prospective Cohort StudiesUNKNOWNOBSERVATIONALNordic diet
NCT02716870Effect of Important Food Sources of Fructose-containing Sugars on Cardiometabolic Risk Factors: A Series of Systematic Reviews and Meta-analyses of Controlled Trials to Inform Dietary Guidelines, Public Health Policy, and Future Trial DesignUNKNOWNOBSERVATIONALFructose-containing Sugars
NCT01608620The Relation of Total and Individual Fructose-containing Sugars With Incident Cardiometabolic Diseases: A Series of Systematic Reviews and Meta-analyses of Prospective Observational StudiesUNKNOWNOBSERVATIONAL

Genetic associations (0)

None linked.