A
Psoriasis
Inflammatory & ImmuneDisease / conditionriskpartially modifiable
52
evidence score
Also known as: chronic inflammatory nature of psoriasis, psoriatic, systemic inflammation (psoriasis-related)
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 21.1meta-analyses: 20trials: 11.1genetic: 0MR bonus:
References (128)
12 meta-analyses / systematic reviews- METAEffects of TNF-α Inhibitors on Subclinical Atherosclerosis and Endothelial Function in Patients with Psoriatic Arthritis: A Systematic Review. — La Tunisie medicale 2025 · PMID 41848140
- METAPsoriasis treatments in the stabilization of atherosclerosis: a systematic review. — Archives of dermatological research 2024 · PMID 39739136
- METAPsoriasis Increased the Risk of Adverse Cardiovascular Outcomes: A New Systematic Review and Meta-Analysis of Cohort Study — Frontiers in Cardiovascular Medicine 2022 · PMID 35402553
- METAPsoriasis and cardiovascular disease risk in European and East Asian populations: evidence from meta-analysis and Mendelian randomization analysis. — BMC medicine 2022 · PMID 36320003
- METAAssociation of Psoriasis With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. — JAMA dermatology 2018 · PMID 30422277
- METAImpact of biologic therapies on risk of major adverse cardiovascular events in patients with psoriasis: systematic review and meta-analysis of randomized controlled trials — British Journal of Dermatology 2016 · PMID 27518205
- METAPsoriasis and Major Adverse Cardiovascular Events: A Systematic Review and Meta‐Analysis of Observational Studies — Journal of the American Heart Association 2013 · PMID 23557749
- METAQuantifying cardiovascular disease risk factors in patients with psoriasis: a meta-analysis — British Journal of Dermatology 2013 · PMID 23815240
- METAPsoriasis, cardiovascular events, cancer risk and alcohol use: evidence‐based recommendations based on systematic review and expert opinion — Journal of the European Academy of Dermatology and Venereology 2013 · PMID 23845148
- METAPsoriasis and smoking: a systematic review and meta‐analysis — British Journal of Dermatology 2013 · PMID 24117435
- METAMeta-analysis of psoriasis, cardiovascular disease, and associated risk factors. — Journal of the American Academy of Dermatology 2013 · PMID 24238156
- METACardiovascular risk factors in patients with plaque psoriasis: a systematic review of epidemiological studies — Journal of the European Academy of Dermatology and Venereology 2010 · PMID 20443997
- Skin Inflammation, Systemic Inflammation, and Cardiovascular Disease in Psoriasis. — JAMA dermatology 2025 · PMID 39565616
- Cardiovascular disease risk in patients with psoriasis receiving biologics targeting TNF-α, IL-12/23, IL-17, and IL-23: A population-based retrospective cohort study. — PLoS medicine 2025 · PMID 40245096
- Associations of serum 25-hydroxyvitamin D concentrations with risks of mortality and cardiovascular disease among individuals with psoriasis. — Journal of the American Academy of Dermatology 2025 · PMID 40378890
- The impact of lifestyle factors on cardiometabolic comorbidities and mortality of psoriatic diseases: A multistate model analysis. — Journal of the American Academy of Dermatology 2025 · PMID 40383272
- Platelet Activation and a Platelet Biosignature Are Associated With Cardiovascular Risk in Patients With Controlled Psoriasis. — Arteriosclerosis, thrombosis, and vascular biology 2025 · PMID 40905118
- Psoriasis and phenotypic age acceleration in relation to all-cause and cardiovascular disease mortality risks in US adults. — European journal of medical research 2025 · PMID 41024224
- Psoriasis Comorbidities and Their Treatment Impact. — Dermatologic clinics 2024 · PMID 38796272
- Exploring the Link Between Genetic Predictors of Cardiovascular Disease and Psoriasis. — JAMA cardiology 2024 · PMID 39292496
- Psoriasis management tree based on comorbidity. — International journal of dermatology 2024 · PMID 39420121
- Biologics for Reducing Cardiovascular Risk in Psoriasis Patients — Journal of Clinical Medicine 2023 · PMID 36769825
- Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis? — Anais brasileiros de dermatologia 2023 · PMID 37198010
- Platelet activation: a promoter for psoriasis and its comorbidity, cardiovascular disease. — Frontiers in immunology 2023 · PMID 37654493
- Selected miRNA and Psoriasis-Cardiovascular Disease (CVD)-Overweight/Obesity Network-A Pilot Study. — International journal of molecular sciences 2023 · PMID 37762217
- Evaluation and treatment of metabolic syndrome and cardiovascular disease in adult patients with psoriasis. — International journal of dermatology 2023 · PMID 37845786
- Cardiovascular Disease-Associated Skin Conditions. — Vascular health and risk management 2022 · PMID 35210782
- Psoriasis and metabolic syndrome: implications for the management and treatment of psoriasis. — Journal of the European Academy of Dermatology and Venereology : JEADV 2022 · PMID 35238067
- Psoriasis and Cardiovascular Risk in Children: The Usefulness of Carotid Intima-Media Thickness. — Pediatric cardiology 2022 · PMID 35316356
- Gut–Skin Axis: Unravelling the Connection between the Gut Microbiome and Psoriasis — Biomedicines 2022 · PMID 35625774
- The Association Between Psoriasis and Risk of Cardiovascular Disease: A Mendelian Randomization Analysis — Frontiers in Immunology 2022 · PMID 35844511
- Psoriasis and Cardiometabolic Diseases: Shared Genetic and Molecular Pathways. — International journal of molecular sciences 2022 · PMID 36012327
- Shared genetic risk factors and causal association between psoriasis and coronary artery disease. — Nature communications 2022 · PMID 36323703
- Autoimmune diseases and cardiovascular risk. — Trends in molecular medicine 2022 · PMID 36357282
- Cardiovascular Risk Assessment and Impact of Medications on Cardiovascular Disease in Inflammatory Bowel Disease. — Inflammatory bowel diseases 2021 · PMID 32978937
- Psoriasis: Comorbidities. — The Journal of dermatology 2021 · PMID 33763899
- Cardiovascular Risk in Patients With Psoriasis: JACC Review Topic of the Week. — Journal of the American College of Cardiology 2021 · PMID 33795041
- Psoriasis and Diabetes, a Dangerous Association: Evaluation of Insulin Resistance, Lipid Abnormalities, and Cardiovascular Risk Biomarkers — Frontiers in Medicine 2021 · PMID 33834030
- Carotid intima-media thickness and epicardial fat thickness predict precoronary artery disease status in psoriasis. — Indian journal of dermatology, venereology and leprology 2021 · PMID 33871214
- Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis — International Journal of Molecular Sciences 2021 · PMID 33924414
- Methotrexate and cardiovascular risk in rheumatic diseases:A comprehensive review. — Expert review of clinical pharmacology 2021 · PMID 34006152
- Arterial stiffness, the hidden face of cardiovascular risk in autoimmune and chronic inflammatory rheumatic diseases. — Autoimmunity reviews 2021 · PMID 34229047
- Psoriasis and Cardiovascular Disease: Novel Mechanisms and Evolving Therapeutics. — Current atherosclerosis reports 2021 · PMID 34468875
- Cardiovascular Disease in Spondyloarthritides. — Current vascular pharmacology 2020 · PMID 31330576
- Psoriasis and Co-morbidity. — Acta dermato-venereologica 2020 · PMID 31971602
- Psoriasis and Cardiovascular Risk: A Comprehensive Review. — Advances in therapy 2020 · PMID 32314303
- Investigating the Link between Psoriasis and Cardiovascular Disease: Current Evidence, Therapeutic Implications and Perspectives. — Current vascular pharmacology 2020 · PMID 32445456
- National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study — BMJ 2020 · PMID 32467098
- Cardio-Rheumatology: Two Collaborating Disciplines to Deal with the Enhanced Cardiovascular Risk in Autoimmune Rheumatic Diseases. — Current vascular pharmacology 2020 · PMID 32693768
- Inflammatory Bowel Disease and Atherosclerotic Cardiovascular Disease: JACC Review Topic of the Week. — Journal of the American College of Cardiology 2020 · PMID 33303079
- Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities. — Journal of the American Academy of Dermatology 2019 · PMID 30772097
- Psoriasis Pathogenesis and Treatment — International Journal of Molecular Sciences 2019 · PMID 30909615
- Association of Ustekinumab vs TNF Inhibitor Therapy With Risk of Atrial Fibrillation and Cardiovascular Events in Patients With Psoriasis or Psoriatic Arthritis — JAMA Dermatology 2019 · PMID 30916734
- Management of psoriasis as a systemic disease: what is the evidence? — The British journal of dermatology 2019 · PMID 31225638
- Risk Factors for the Development of Psoriasis — International Journal of Molecular Sciences 2019 · PMID 31491865
- Risk of major cardiovascular events in patients with psoriasis receiving biologic therapies: a prospective cohort study — Journal of the European Academy of Dermatology and Venereology 2019 · PMID 31633837
- The Skin and Gut Microbiome and Its Role in Common Dermatologic Conditions — Microorganisms 2019 · PMID 31717915
- Psoriasis, cardiovascular risk factors and metabolic disorders: sex‐specific findings of a population‐based study — Journal of the European Academy of Dermatology and Venereology 2019 · PMID 31797464
- Interleukin 17, inflammation, and cardiovascular risk in patients with psoriasis — Journal of the American Academy of Dermatology 2018 · PMID 29477740
- Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences — Frontiers in Immunology 2018 · PMID 29675020
- Psoriasis as a cardiovascular risk factor: updates and algorithmic approach. — Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 2018 · PMID 29683293
- Potential Immunological Links Between Psoriasis and Cardiovascular Disease. — Frontiers in immunology 2018 · PMID 29910818
- Psoriasis, metabolic syndrome and cardiovascular risk factors. A population‐based study — Journal of the European Academy of Dermatology and Venereology 2018 · PMID 29953676
- Systemic Inflammatory Response and Atherosclerosis: The Paradigm of Chronic Inflammatory Rheumatic Diseases. — International journal of molecular sciences 2018 · PMID 29954107
- [Psoriasis,Cardiovascular Disease,and Adipokines]. — Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2018 · PMID 30193612
- Psoriasis and cardiovascular disease: the elusive link. — International reviews of immunology 2018 · PMID 30457023
- Psoriasis and comorbid diseases: Epidemiology. — Journal of the American Academy of Dermatology 2017 · PMID 28212759
- Clinical, Diagnostic, and Therapeutic Implications in Psoriasis Associated With Cardiovascular Disease. — Actas dermo-sifiliograficas 2017 · PMID 28610662
- Psoriasis and Cardiovascular Comorbidities: Focusing on Severe Vascular Events, Cardiovascular Risk Factors and Implications for Treatment — International Journal of Molecular Sciences 2017 · PMID 29065479
- GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk — Journal of Translational Medicine 2017 · PMID 29078787
- Cardiovascular Risk in Psoriasis: Current State of the Art — Current Vascular Pharmacology 2017 · PMID 29149819
- Psoriasis and Cardiovascular Risk: Correlation Between Psoriasis and Cardiovascular Functional Indices — Angiology 2017 · PMID 29212353
- [Comorbidity in psoriasis]. — Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 2016 · PMID 27221798
- Psoriasis and cardiovascular disorders. — Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 2016 · PMID 27627099
- Incidence and Prevalence of Cardiovascular Risk Factors Among Patients With Rheumatoid Arthritis, Psoriasis, or Psoriatic Arthritis — Arthritis Care & Research 2016 · PMID 27998029
- Psoriasis and Obesity — Dermatology 2016 · PMID 28226326
- Obesity and inflammation: the linking mechanism and the complications — Archives of Medical Science 2016 · PMID 28721154
- Psoriasis is a systemic disease with multiple cardiovascular and metabolic comorbidities. — Dermatologic clinics 2015 · PMID 25412782
- Psoriasis as an Independent Risk Factor for Cardiovascular Disease — Journal of Cutaneous Medicine and Surgery 2015 · PMID 26316538
- Psoriasis and Cardiovascular Disease. — The Medical clinics of North America 2015 · PMID 26476250
- Role of C-reactive protein as a marker of disease severity and cardiovascular risk in patients with psoriasis — Indian Dermatology Online Journal 2015 · PMID 26500861
- Effect of Weight Loss on the Cardiovascular Risk Profile of Obese Patients with Psoriasis — Acta Dermato Venereologica 2014 · PMID 24556829
- Immunology of Psoriasis — Annual Review of Immunology 2014 · PMID 24655295
- Cardiovascular Risk and Psoriasis — Angiology 2014 · PMID 24671131
- Comorbidities and cardiovascular risk factors in patients with psoriasis — Anais Brasileiros de Dermatologia 2014 · PMID 25184912
- Inflammation, atherosclerosis, and psoriasis. — Clinical reviews in allergy & immunology 2013 · PMID 22359071
- Cardiovascular morbidity and mortality in psoriasis and psoriatic arthritis: a systematic literature review — Journal of the European Academy of Dermatology and Venereology 2013 · PMID 23845149
- Elevated serum levels of endocan in patients with psoriasis vulgaris: correlations with cardiovascular risk and activity of disease — British Journal of Dermatology 2013 · PMID 23889284
- Cardiovascular risk and psoriasis: beyond the traditional risk factors. — The American journal of medicine 2013 · PMID 24161194
- [Psoriasis and cardiovascular disease]. — Acta medica portuguesa 2013 · PMID 24192101
- Psoriasis. — The journal of the Royal College of Physicians of Edinburgh 2013 · PMID 24350319
- The concept of psoriasis as a systemic inflammation: implications for disease management — Journal of the European Academy of Dermatology and Venereology 2012 · PMID 22356630
- Analysis of Cardiovascular Risk Factors and Metabolic Syndrome in Korean Patients with Psoriasis — Annals of Dermatology 2012 · PMID 22363149
- Re‐evaluation of the risk for major adverse cardiovascular events in patients treated with anti‐IL‐12/23 biological agents for chronic plaque psoriasis: a meta‐analysis of randomized controlled trials — Journal of the European Academy of Dermatology and Venereology 2012 · PMID 22404103
- Psoriasis and cardiovascular disorders. — Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 2012 · PMID 22481581
- Psoriasis and cardiovascular risk. Assessment by different cardiovascular risk scores — Journal of the European Academy of Dermatology and Venereology 2012 · PMID 22731956
- Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe Psoriasis — Journal of Investigative Dermatology 2012 · PMID 22763790
- Association Between Tumor Necrosis Factor Inhibitor Therapy and Myocardial Infarction Risk in Patients With Psoriasis — Archives of Dermatology 2012 · PMID 22911151
- Risk and predictors of cardiovascular disease in psoriasis: a population‐based study — International Journal of Dermatology 2012 · PMID 23278607
- Effective continuous systemic therapy of severe plaque‐type psoriasis is accompanied by amelioration of biomarkers of cardiovascular risk: results of a prospective longitudinal observational study — Journal of the European Academy of Dermatology and Venereology 2011 · PMID 21241371
Clinical trials (12)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07485764 | A Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial to Evaluate the Efficacy and Safety of Metformin in Combination With Secukinumab for the Treatment of Moderate-to-Severe Plaque Psoriasis in Overweight or Obese Chinese Patients | NOT YET RECRUITING | INTERVENTIONAL | Secukinumab 300mg s.c., Metformin, Placebo |
| NCT05908240 | Prevention of Cardiovascular Disease and Mortality in Patients With Psoriasis or Psoriatic Arthritis: Translating Guidelines of Care to Better Outcomes for Patients With Psoriatic Disease | ACTIVE NOT RECRUITING | INTERVENTIONAL | Care Coordinator Model |
| NCT06475586 | Effect of Semaglutide on the Inflammatory Response and Clinical Course of Psoriatic Lesions in Patients With Type 2 Diabetes Mellitus | COMPLETED | INTERVENTIONAL | Semaglutide |
| NCT03625089 | The Impact of Nurse-led Programme With and Without Carotid Ultrasound on Addressing Cardiovascular Risk in Patients With Arthritis: a Prospective, Multicentre, Randomised, Controlled Trial | WITHDRAWN | INTERVENTIONAL | Atorvastatin |
| NCT02432040 | Atorvastatin as Adjunctive Therapy for Chronic Plaque Type Psoriasis Versus Betamethasone Valerate Alone:A Randomized, Double-Blind, Placebo-Controlled Trial | COMPLETED | INTERVENTIONAL | Atorvastatin, Placebo |
| NCT01714284 | Multicenter Randomized Clinical Study Evaluating the Efficacy of Dietary Intervention and Weight Loss in Improving Psoriasis | COMPLETED | INTERVENTIONAL | Informative, Diet and Exercise |
| NCT01704599 | A Single-Center, Open-Label Study to Assess the Effects of the Addition of Modulators of Homocysteine to Adalimumab Therapy in the Treatment of Moderate to Severe Plaque Psoriasis Evaluated With the PASI, PGA and DLQI | TERMINATED | INTERVENTIONAL | Humira Then Humira plus 3 B vitamins |
| NCT00477191 | Effects of TNF-alpha Antagonism (Etanercept) in Patients With the Metabolic Syndrome and Psoriasis | TERMINATED | INTERVENTIONAL | Etanercept |
| NCT07567378 | Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts (CARTIZ): A Prospective Observational Multi-Institutional Registry of the VAT-Articular-Cardiac-Aging Axis in Adults Exposed to Tirzepatide in Mexico, With Quantitative Knee Cartilage T2 Mapping, Cardiac CT Epicardial Adipose Tissue Radiomic Phenotyping, HLA Stratification, Longitudinal Multi-Frequency Bioimpedance Body Composition, and a Prespecified Surgical Tissue Acquisition Subcohort | NOT YET RECRUITING | OBSERVATIONAL | Tirzepatide |
| NCT01778569 | Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic Disease (PACI) Initiative | COMPLETED | OBSERVATIONAL | |
| NCT01401452 | Effectiveness of Adalimumab in Moderate to Severe Plaque Psoriasis Patients With Distinct Co-morbidities | COMPLETED | OBSERVATIONAL | |
| NCT01356758 | Cardiovascular Risk Assessment in Patients With Severe Psoriasis Treated With Biologic Agents | COMPLETED | OBSERVATIONAL | biological treatment |
Genetic associations (0)
None linked.