A
Retinal microvascular changes
Imaging & Subclinical DiseaseImaging markerrisknon modifiable
46
evidence score
Also known as: retinal, retinopathy
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 15.2meta-analyses: 17.6trials: 13genetic: 0MR bonus:
References (32)
6 meta-analyses / systematic reviews- METAIncidence and risk factors associated with ischemic cerebrovascular disease in patients with retinal artery occlusion: a systematic review and meta-analysis. — Scientific reports 2025 · PMID 41006752
- METARETINAL MICROVASCULAR CHANGES AND RISK OF CORONARY HEART DISEASE: A Systematic Review and Meta-Analysis. — Retina (Philadelphia, Pa.) 2024 · PMID 37831943
- METAThe relationship between carotid disease and retinopathy in diabetes: a systematic review. — Cardiovascular diabetology 2020 · PMID 32375803
- METAPhysical activity and exercise improve retinal microvascular health as a biomarker of cardiovascular risk: A systematic review. — Atherosclerosis 2020 · PMID 33212315
- METARetinal vein occlusion and risk of cerebrovascular disease and myocardial infarction: A meta-analysis of cohort studies. — Atherosclerosis 2016 · PMID 26922716
- METAMeta-analysis: retinal vessel caliber and risk for coronary heart disease. — Annals of internal medicine 2009 · PMID 19755365
- Remnant Cholesterol and Cardiovascular Risk in Adults With Type 1 Diabetes: A Nested Case-Control Study. — Endocrinology, diabetes & metabolism 2025 · PMID 41058311
- Genetic predisposition and mediating pathways in ischemic stroke-induced cardiac arrhythmias: a genome-wide analysis. — Journal of advanced research 2025 · PMID 41461312
- Diabetic Vasculopathy: Molecular Mechanisms and Clinical Insights. — International journal of molecular sciences 2024 · PMID 38255878
- Lifetime and 10-year cardiovascular risk prediction in individuals with type 1 diabetes: The LIFE-T1D model. — Diabetes, obesity & metabolism 2024 · PMID 38456579
- Risk and risk factor of ischemic stroke after acute retinal arterial ischemia. — International ophthalmology 2023 · PMID 36976411
- 8-Aminopurines in the Cardiovascular and Renal Systems and Beyond. — Hypertension (Dallas, Tex. : 1979) 2023 · PMID 37503660
- Genome-Wide Association Study of Cardiovascular Resilience Identifies Protective Variation in theGene. — Journal of the American Heart Association 2023 · PMID 37929782
- Gut microbiome and diabetic retinopathy. — European journal of ophthalmology 2022 · PMID 35266406
- Level of education is associated with coronary heart disease and chronic kidney disease in individuals with type 2 diabetes: a population-based study. — BMJ open diabetes research & care 2022 · PMID 36171015
- Diet quality trajectories and cardiovascular phenotypes/metabolic syndrome risk by 11-12 years. — International journal of obesity (2005) 2021 · PMID 33824404
- Deep-learning-based cardiovascular risk stratification using coronary artery calcium scores predicted from retinal photographs — The Lancet Digital Health 2021 · PMID 33890578
- Obstructive sleep apnea and the retina: a review. — Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2021 · PMID 34165073
- Seeing stars: Development and function of retinal astrocytes. — Developmental biology 2021 · PMID 34260962
- What is the impact of microvascular complications of diabetes on severe COVID-19? — Microvascular research 2021 · PMID 34979154
- Associations between abdominal obesity indices and diabetic complications: Chinese visceral adiposity index and neck circumference. — Cardiovascular diabetology 2020 · PMID 32736628
- Microvascular Disease, Peripheral Artery Disease, and Amputation — Circulation 2019 · PMID 31280589
- Migraine and stroke. — Stroke and vascular neurology 2017 · PMID 28989805
- Effects of air pollution on human health and practical measures for prevention in Iran — Journal of Research in Medical Sciences 2016 · PMID 27904610
- Global Prevalence and Major Risk Factors of Diabetic Retinopathy — Diabetes Care 2012 · PMID 22301125
- Evaluation of erectile dysfunction and associated cardiovascular risk using structured questionnaires in Chinese type 2 diabetic men — International Journal of Andrology 2010 · PMID 20059584
- Retinal Vein Occlusion and Traditional Risk Factors for Atherosclerosis — Archives of Ophthalmology 2008 · PMID 18474782
- Traditional and Novel Cardiovascular Risk Factors for Retinal Vein Occlusion: The Multiethnic Study of Atherosclerosis — Investigative Ophthalmology & Visual Science 2008 · PMID 18539932
- Retinal Vascular Caliber, Cardiovascular Risk Factors, and Inflammation: The Multi-Ethnic Study of Atherosclerosis (MESA) — Investigative Ophthalmology & Visual Science 2006 · PMID 16723443
- Is Diabetic Retinopathy an Independent Risk Factor For Ischemic Stroke? — Stroke 2006 · PMID 17194880
- Risk Factors for Coronary Heart Disease in Type 1 Diabetic Patients in Europe — Diabetes Care 2004 · PMID 14747240
- Development and pathology of the hyaloid, choroidal and retinal vasculature. — The International journal of developmental biology 2004 · PMID 15558494
Clinical trials (19)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07420374 | Ambulatory Stroke Unit Treatment for Elderly Patients: A Prospective, Randomized, Controlled, Exploratory Non-Inferiority Trial (ARTIFICE) | RECRUITING | INTERVENTIONAL | Ambulatory Stroke Unit Care, Conventional Stroke Unit Care |
| NCT06989996 | Study of Human Ocular Hemodynamics by Holography Dopple | NOT YET RECRUITING | INTERVENTIONAL | Images Acquisition |
| NCT05802108 | Effect of PCSK9 Inhibitor on Retinal Microvessels in Patients With Coronary Heart Disease After Intensive Lipid-lowering Therapy | UNKNOWN | INTERVENTIONAL | Evolocumab combined with statins, Statin |
| NCT05310916 | Evaluation of the Effect of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors on Diabetic Retinopathy in Patients With Type 2 Diabetes Mellitus | UNKNOWN | INTERVENTIONAL | Dapagliflozin 10mg Tab plus another oral hypoglycemic agent, Two oral hypoglycemic agents other than dapagliflozin |
| NCT05615740 | Prevention of Onset and Transition to an Advanced Form of Diabetic Retinopathy in Children | ACTIVE NOT RECRUITING | INTERVENTIONAL | Optical coherence tomography (OCTA) |
| NCT04447599 | Study of Conjunctival and Retinal Blood Vessels for the Evaluation of the Load of Small Vessel Disease in Patients With Transient Ischemic Attacks (TIAs) and Minor Strokes | UNKNOWN | INTERVENTIONAL | photography of conjunctival vessels |
| NCT04140201 | Evaluation of Lipid Lowering Agents on Diabetic Retinopathy and Cardiovascular Risk of Diabetic Patients | UNKNOWN | INTERVENTIONAL | Simvastatin 40mg, Fenofibrate 200mg, Omega 3 fatty acid |
| NCT01589029 | A Pilot Study on the Effects of ILARIS® on Patients With Proliferative Diabetic Retinopathy (PDRP) | TERMINATED | INTERVENTIONAL | CANAKINUMAB (ILARIS®) |
| NCT00939276 | Macular Edema Incidence/Severity Reduction With Nevanac | TERMINATED | INTERVENTIONAL | Nepafenac ophthalmic suspension, 0.1% (NEVANAC®), Nepafenac ophthalmic suspension vehicle |
| NCT00370760 | Oral Colchicine Combined With Intravitreal Infusion of Dexamethasone, LMW Heparin and 5-FU for Management of Proliferative Vitreoretinopathy (PVR) | UNKNOWN | INTERVENTIONAL | oral colchicine, dexamethasone, low molecular weight heparin, 5-FU, placebo |
| NCT06085612 | Impact of Significant Carotid Stenosis on Retinal Perfusion Measured Via Automated Retinal Oximetry | RECRUITING | OBSERVATIONAL | Automated retinal oximetry |
| NCT01793168 | Coordination of Rare Diseases at Sanford | RECRUITING | OBSERVATIONAL | |
| NCT06423274 | A Comparative Analysis of the Diagnostic Outcomes of Artificial Intelligence-assisted Fundus Photography for Diabetic Retinopathy and Diabetic Macular Edema Versus Other Imaging Devices in Ophthalmology: A Controlled Trial | NOT YET RECRUITING | OBSERVATIONAL | fundus photography, optical coherence tomography, fundus fluorescence angiography |
| NCT07602348 | Assessment of Retinal-Angio Findings in Patients With Diabetes Type II Treated With Novel Antidiabetic Therapies | ACTIVE NOT RECRUITING | OBSERVATIONAL | |
| NCT05735938 | Use of Automtic Retinal Image Analysis in Risk Stratification for Chest Pain Patients Presenting to Emergency Departments Suspected Acute Coronary Syndrome | TERMINATED | OBSERVATIONAL | |
| NCT05623293 | Prognostic Predictors of Cardiovascular and Ophthalmologic Outcomes in Patients With Carotid Artery Stenosis Undergoing Carotid Endarterectomy With Regional Anesthesia - A Prospective Study | UNKNOWN | OBSERVATIONAL | eye - Optcial coherence tomography |
| NCT05080153 | The Effects of Vitamin Supplementation Containing L-Methylfolate (Ocufolin® Forte) on Retinal Venous Pressure and Homocysteine Plasma Levels in Patients With Glaucoma | COMPLETED | OBSERVATIONAL | Ocufolin forte |
| NCT00498147 | Does Managed Diabetes Care Decrease Cardiovascular Complications of Diabetes? | UNKNOWN | OBSERVATIONAL | ADEC Program |
| NCT02483650 | The Registry of Hyperbaric Oxygen Therapy Treated Patients | UNKNOWN | OBSERVATIONAL |
Genetic associations (0)
None linked.