B
Saturated fat intake
Lifestyle & BehavioralBehavior / exposureriskmodifiable
29
evidence score
Also known as: dietary saturated fat, saturated fat
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 11.8meta-analyses: 6trials: 11.4genetic: 0MR bonus:
References (14)
1 meta-analyses / systematic reviews- METAMeta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. — The American journal of clinical nutrition 2010 · PMID 20071648
- The portfolio dietary pattern and risk of cardiovascular disease mortality during 1988-2019 in US adults: a prospective cohort study. — BMC medicine 2025 · PMID 40394599
- Association between fatty acids and coronary heart disease: A scoping review. — The Medical journal of Malaysia 2022 · PMID 35086997
- Reduction in saturated fat intake for cardiovascular disease. — The Cochrane database of systematic reviews 2020 · PMID 32428300
- Diet and Lp(a): Does Dietary Change Modify Residual Cardiovascular Risk Conferred by Lp(a)? — Nutrients 2020 · PMID 32646066
- Diet Quality, Saturated Fat and Metabolic Syndrome. — Nutrients 2020 · PMID 33105691
- The Mediterranean Diet and Cardiovascular Health. — Circulation research 2019 · PMID 30817261
- Mediterranean-style diet for the primary and secondary prevention of cardiovascular disease. — The Cochrane database of systematic reviews 2019 · PMID 30864165
- Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women. — BMJ open 2018 · PMID 29511019
- Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars. — Diabetes care 2018 · PMID 29844096
- Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). — BMJ (Clinical research ed.) 2016 · PMID 27071971
- When and how to start prevention of atherosclerosis? Lessons from the Cardiovascular Risk in the Young Finns Study and the Special Turku Coronary Risk Factor Intervention Project. — Pediatric nephrology (Berlin, Germany) 2011 · PMID 21877168
- Saturated Fat and Cardiometabolic Risk Factors, Coronary Heart Disease, Stroke, and Diabetes: a Fresh Look at the Evidence — Lipids 2010 · PMID 20354806
- Risk factors for coronary heart disease in children and young adults. — Acta paediatrica (Oslo, Norway : 1992). Supplement 2004 · PMID 15702668
Clinical trials (13)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07004777 | Effect of Consuming n-3 Polyunsaturated Fatty Acids Rich Foods on Triglyceride Concentration and Lipoprotein Composition in Individuals With Hypertriglyceridemia. Controlled Clinical Trial. | RECRUITING | INTERVENTIONAL | Isocaloric diet including chia and pumpkin seeds, Isocaloric diet |
| NCT05725486 | Effects of N-3 Polyunsaturated Fatty Acids Enriched Chicken Meet on Cardiovascular Function | UNKNOWN | INTERVENTIONAL | N-3 PUFAs Chicken Meet, Regular Chicken Meet |
| NCT04564690 | Effect of Enriched QUARTET® Hen Eggs on Cardiovascular Function in Cardiovascular Patients and Healthy Individuals | UNKNOWN | INTERVENTIONAL | QUARTET® hen eggs (enriched in n-3 PUFA, selenium, vitamin E and lutein), Regular hen eggs |
| NCT04647604 | Resolving Inflammatory Storm in COVID-19 Patients by Omega-3 Polyunsaturated Fatty Acids - A Single-blind, Randomized, Placebo-controlled Feasibility Study | COMPLETED | INTERVENTIONAL | Omegaven®, Sodium chloride |
| NCT03072823 | Omega-3 Polyunsaturated Fatty Acids on Major Depressive Disorder in Patients With Cardiovascular Diseases: a Double-blind Placebo-controlled Therapeutic Trial | COMPLETED | INTERVENTIONAL | n-3 Polyunsaturated fatty acid, placebo |
| NCT01762072 | Effect of Vitamin B12 and n-3 Polyunsaturated Fatty Acids on Plasma Homocysteine | UNKNOWN | INTERVENTIONAL | Fish oil, vitaminB12 |
| NCT01521845 | Phase 3 Study of Poly Unsaturated Fatty Acids of Omega 3 as an Anti Platelet Agent on Biomarkers of Cardiac Necrosis Including CKMB and Troponin I and Inflammation Marker CRP | COMPLETED | INTERVENTIONAL | omega 3 |
| NCT01526824 | The Effects of Polyunsaturated Omega-3 Fatty Acids (Lovaza) on Patients Taking Clopidogrel +/- Aspirin Who Have Suffered an Ischemic Stroke/TIA and/or Are Candidates for Neuroendovascular Stenting. | UNKNOWN | INTERVENTIONAL | omega-3 polyunsaturated fatty acids (Lovaza) |
| NCT01367145 | OMEGA-3-POLYUNSATURATED FATTY-ACIDS (n3-PUFA) IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE: EFFECTS ON ENDOTHELIAL FUNCTION - A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND TRIAL | COMPLETED | INTERVENTIONAL | OMACOR, Placebo |
| NCT01061554 | Correlation Between Level of Polyunsaturated Fatty Acid EPA and DHA in Blood After Digestion of ProBios Omega-3 Concordix™ Compared With Omega-3 Soft Capsules - a Pilot | COMPLETED | INTERVENTIONAL | Omega-3 oils from tri-glycerides, Omega-3 oils from marine phospholipids |
| NCT00508937 | The Effects of Increased Dietary Protein Intake on Insulin Sensitivity in Stable Weight Individuals, Independent of Dietary Content of Carbohydrate and Saturated Fat | COMPLETED | INTERVENTIONAL | Diet, Diet, Diet |
| NCT00317707 | Risk and Prevention Study: Optimisation of the Preventive Strategies and Evaluation of the Efficacy of n-3 PUFA in Subjects at High Cardiovascular Risk | COMPLETED | INTERVENTIONAL | N-3 Polyunsaturated Fatty Acids, Placebo: Olive oil |
| NCT00479791 | Lipid, Glycemic, and Insulin Responses to Meals Rich in Saturated, Cis-Monounsaturated, and Polyunsaturated Fatty (n-3 and n-6)Acids in Subjects With Type 2 Diabetes Mellitus | COMPLETED | INTERVENTIONAL | Test meals rich in different fatty acids |
Genetic associations (0)
None linked.