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Serum uric acid

Renal & ElectrolyteLab test / biomarkerriskmodifiable
52
evidence score

Also known as: Hyperuricemia, Serum uric acid levels, Uric acid, elevated serum uric acid, elevated serum uric acid levels, elevated uric acid, hyperuricaemia, hyperuricemia, increase of serum uric acid, serum urate, serum uric acid is inversely associated with disease severity and especially with cardiovascular disease states, uric acid

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 21.8meta-analyses: 19.3trials: 10.4genetic: 0MR bonus:

References (152)

7 meta-analyses / systematic reviews

Clinical trials (10)

NCTTitleStatusTypeInterventions
NCT04875702Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout: A Randomized Controlled TrialRECRUITINGINTERVENTIONALAllopurinol, Naproxen 250 MG, Colchicine 0.6 mg
NCT04697602Low-dose Colchicine With or Without Stepwise Dose Titration of Febuxostat for Flare Prophylaxis in Patients With Gout and Hyperuricemia During the Initial Phase of Urate-lowering Therapy: an Open-label Randomized Controlled TrialTERMINATEDINTERVENTIONALStepwise dose titration of febuxostat and low-dose colchicine, Fixed dose febuxostat and low-dose colchicine
NCT03226899A Phase 4, Study to Evaluate the Safety and Efficacy of Lesinurad 200 mg in Combination With a Xanthine Oxidase Inhibitor (XOI), Compared With an XOI Alone, in Subjects With Gout and Estimated Creatinine Clearance (eCrCl) 30 to <60 mL/Min Who Have Not Achieved Target Serum Uric Acid Levels (sUA) on an XOI AloneTERMINATEDINTERVENTIONALLesinurad, XOI, Placebo
NCT02462421Pharmacogenetics of Sodium-dependent Glucose Transporter-2 (SGLT2) InhibitorsTERMINATEDINTERVENTIONALCanagliflozin
NCT02252835A Phase 2, Open-label, Drug-Drug Interaction Study to Evaluate the Pharmacodynamics, Pharmacokinetics, and Safety of Arhalofenate in Combination With Febuxostat for the Treatment of Hyperuricemia in Patients With GoutCOMPLETEDINTERVENTIONALArhalofenate, Febuxostat, Arhalofenate
NCT01112982Shifting the Paradigm of Gout: An Assessment of Chronic Synovial-Based Inflammation and Its Role With Serum Urate Levels.COMPLETEDINTERVENTIONALMagnetic Resonance Imaging, Febuxostat, Colchicine
NCT00738842A Randomised, Double-Blind, Two-Period Crossover Study to Assess the Effect of AZD6140 on Uric Acid Levels in Healthy Male VolunteersCOMPLETEDINTERVENTIONALAZD6140, Placebo to match AZD6140
NCT07017868Correlation Between Serum Uric Acid, Serum Homocysteine Level and Interleukin- 17 in Lupus Nephritis PatientsRECRUITINGOBSERVATIONALinterleukin- 17
NCT05342285Flow Mediated Dilation in Association With Hyperuricemia as Predictors of Cardiovascular Affection in Patients With Systemic LupusUNKNOWNOBSERVATIONALFlow mediated dilation
NCT04554069Effect of Different Antihypertensive Treatment on Serum Uric Acid in Newly Diagnosed Hypertensive PatientsUNKNOWNOBSERVATIONAL

Genetic associations (0)

None linked.