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Systemic inflammation

Inflammatory & ImmuneLab test / biomarkerriskpartially modifiablegenetic-causal
90
evidence score

Also known as: Elevated inflammatory markers, Increased inflammation, Inflammation, Inflammation / inflammatory state, Inflammatory markers, Inflammatory state, Subclinical inflammation, Systemic inflammation markers, chronic inflammation, chronic inflammatory component, chronic tissue-destructive inflammation, disease-associated inflammation

PREVENT status

Not a PREVENT input variable.

Causal support

genetic causal candidate

Score components
lit volume: 24.9meta-analyses: 20trials: 15genetic: 20MR bonus:
Associated genes
IL6R

References (306)

12 meta-analyses / systematic reviews

Clinical trials (440)

showing top 60
NCTTitleStatusTypeInterventions
NCT06855433A Randomized, Double-Blind, Multi-Site Placebo Controlled Trial of Colchicine in Calcium Pyrophosphate Deposition DiseaseRECRUITINGINTERVENTIONALColchicine Pill, Placebo
NCT07362966Precision Colchicine Intervention to Suppress Atherosclerosis in TET2 Clonal Hematopoiesis : a Pilot Clinical Trial (PRECISE)RECRUITINGINTERVENTIONALColchicine 0.5 mg orally once daily for 12 months., SoC therapy
NCT07198789Randomized, Double-Blind, Placebo-Controlled Crossover Clinical Trial to Evaluate the Effect of a Functional Low-Glycemic Index Carbohydrates Versus Standard Wholegrain Carbohydrates on Glycolipid Metabolism and Vascular Stress Markers in Subjects With Suboptimal TriglyceridemiaRECRUITINGINTERVENTIONALAltograno® Bakery Foods, Standard Whole-Grain Bakery Foods
NCT07287345Adjunctive Colchicine's Effect on Inflammatory Markers and Corresponding New-Onset Atrial Fibrillation Rates Post Coronary Artery Bypass Graft Procedure: A Pilot StudyRECRUITINGINTERVENTIONALColchicine (Colcrys®), Placebo
NCT07349875Colchicine Treatment for Non-Flow-Limiting Coronary Plaque by Coronary CTA: A Randomized Controlled TrialRECRUITINGINTERVENTIONALColchicine combined with Guideline-Directed Medical Therapy
NCT06802926A Single Center Pilot Trial of Preliminary Effect of Colchicine on Graft Failure in Patients Underwent CABGRECRUITINGINTERVENTIONALColchicine
NCT07331103RESOLving INflammation Through Diet for Health Multicenter, Prospective Randomized, Controlled and Open- Label to Examine the Impact of a Diet Enriched in Omega 3 Fatty Acids of Animal and Vegetal Origin on Circulating Lipid-driven Pro-/Antiinflammatory Balance in Subjects at Moderate to High Cardiovascular Risk.RECRUITINGINTERVENTIONALFish Oil, Camelina oil, Vitamin E
NCT07361887Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular VesiclesRECRUITINGINTERVENTIONALWhite Wine, Red Wine, Water
NCT07123181Effects of Increasing Polyphenol Intake by Consumption of Oregano and Basil Leaves on Plasma Inflammatory and Lipid Factors and Total Urinary Polyphenol in Patients With Unstable AnginaRECRUITINGINTERVENTIONALControl (Standard treatment), Higher polyphenol intake by consumption of oregano and basil
NCT07145229A Randomized, Double-blind, Multicenter, Colchicine and Placebo-controlled Study to Evaluate the Efficacy and Safety of ABP-745 in Subjects With an Acute Gout FlareRECRUITINGINTERVENTIONALABP-745 Dose A, ABP-745 Dose B, Colchicine
NCT06440694Colchicine to Quench the Inflammatory Response After Deep Vein Thrombosis: A Randomized Controlled Pilot TrialRECRUITINGINTERVENTIONALColchicine 0.5 mg po, Placebo 0.5 mg po
NCT07064109Multi-omics Characterization and Model Construction of Colchicine Anti-inflammatory Therapy Efficacy in Acute Coronary Syndromes PatientsRECRUITINGINTERVENTIONALColchicine 0.5 MG Oral Tablet Once Daily
NCT07026994Colchicine for the Prevention of Recurrence in Cerebral Amyloid Angiopathy RElated IntraCerebral Hemorrhage (CARE-ICH)RECRUITINGINTERVENTIONALColchicine 0.5mg, Matching placebo
NCT06874192Safety and Efficacy of LOw DOse COlchicine in Patients With STatin INTolerance: the LODOCO STINT Pilot StudyRECRUITINGINTERVENTIONALLow-dose colchicine at 0.5mg daily, Placebo
NCT06763055The Fifth INTEnsive pReventing Secondary Injury in Acute Cerebral Haemorrhage Trial Within ACT-GLOBALRECRUITINGINTERVENTIONALColchicine 0.5 mg, Deferoxamine Mesylate, Control (Standard treatment)
NCT06203977Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR)RECRUITINGINTERVENTIONALColchicine
NCT06352632A Multi-faCtorial, mulTi-arm, Multi-staGe, Randomised, gLOBal Adaptive pLatform Trial for Stroke (ACT-GLOBAL)RECRUITINGINTERVENTIONALStandard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase
NCT06543082Clinical Outcomes of Colchicine Therapy Following Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome: the MACT (Mono Antiplatelet and Colchicine Therapy) Prospective Multicenter StudyRECRUITINGINTERVENTIONALColchicine 0.6 mg
NCT06472908Efficacy and Safety of Colchicine After Percutaneous Coronary InterventionRECRUITINGINTERVENTIONALColchicine 0.5 mg, Colchicine 0.375 mg, Placebo
NCT06286423Colchicine in Acutely Decompensated Heart Failure With Reduced Ejection Fraction: a Pilot StudyRECRUITINGINTERVENTIONALColchicine 0.6 mg, Control/Placebo group
NCT06130059Pilot Study to Evaluate the Efficacy of Low Dose Colchicine (LoDoCo ®) to Improve Exercise Capacity Among Patients With Chronic Stable HFpEF and Systemic InflammationRECRUITINGINTERVENTIONALLow Dose Colchicine, Placebo
NCT05890664Colchicine After Electrocardioversion for Atrial Fibrillation - The COLECTRO-AF TrialRECRUITINGINTERVENTIONALColchicine, Placebo
NCT06682390Contribution of Race to Nutritional Approach to Lower Cardiovascular Risk Factors in Men Undergoing Androgen Deprivation TherapyRECRUITINGINTERVENTIONALHypocaloric anti-inflammatory diet
NCT04875702Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout: A Randomized Controlled TrialRECRUITINGINTERVENTIONALAllopurinol, Naproxen 250 MG, Colchicine 0.6 mg
NCT05850247Plaque and Brain Inflammation in Symptomatic Carotid Stenosis: Role of the Ficolin-2RECRUITINGINTERVENTIONAL[18F]DPA-714 PET/MRI
NCT06095765Colchicine in Belgium in Patients With Coronary Artery DiseaseRECRUITINGINTERVENTIONALColchicine 0.5 MG Oral Tablet, Placebo
NCT05873881COLchicine and Thiamine in Heart Failure Due to Ischemic Heart DiseaseRECRUITINGINTERVENTIONALColchicine 0.5 MG, Colchicine placebo, Thiamine Mononitrate 300 mg
NCT05761015A Rehabilitation Walking Program With the Help of a Transient Intake of Nonsteroidal Anti-inflammatory Drug for Patients With Painful Hip/Knee Osteoarthritis - A Pilot Cohort Study With Objectives of Short Walks in the Real Life.RECRUITINGINTERVENTIONALtherapeutic program including intermittent drug intake and multimodal rehabilitation program
NCT06158698Single-blinded Randomized Investigator-initiated Controlled Trial to Assess the Efficacy of Colchicine to Treat Patients With Cardiomyopathy With Myocarditis (Chronic Inflammatory Cardiomyopathy)RECRUITINGINTERVENTIONALColchicine, Placebo
NCT06090890Safety and Efficacy of Low Dose Colchicine or Prednisone Combining With Standard Drug in Patients With Recurrent In-stent Restenosis: a Prospective, Randomized, Open-label TrialRECRUITINGINTERVENTIONALColchicine, Prednisone, Aspirin
NCT05644301INflammation-based Stratification for Immune-Targeted Augmentation in Major DepressiveRECRUITINGINTERVENTIONALCelecoxib, Minocyclin, Placebo
NCT05618353Impact of Colchicine on Peri-Operative Major Adverse Cardiovascular Events in Patients With Prior Coronary RevascularizationRECRUITINGINTERVENTIONALColchicine, Placebo
NCT05986136Activation of Autophagy and Suppression of Apoptosis by Dapagliflozin Attenuates Inflammatory Bowel DiseaseRECRUITINGINTERVENTIONALMesalamine, Dapagliflozin 10mg Tab
NCT05401578Canakinumab for the Treatment of Postprandial Hypoglycemia - CanpHy StudyRECRUITINGINTERVENTIONALCanakinumab, Placebo (0.9% NaCl)
NCT04073797PET Imaging of Inflammation and Lipid Lowering StudyRECRUITINGINTERVENTIONALInclisiran, 68Ga-DOTATATE PET-MRI, Colchicine
NCT05641831A Randomized Double-Blind Placebo-Controlled Phase II Multi-Center Study of Inflammation Modification of Canakinumab to Prevent Leukemic Progression of Clonal Cytopenias of Unknown Significance (CCUS): IMPACT StudyRECRUITINGINTERVENTIONALBiospecimen Collection, Bone Marrow Aspiration and Biopsy, Canakinumab
NCT05633810COLchicine and Non-enteric Coated Aspirin in the Cardiovascular Outcomes Trial of Patients With Type 2 Diabetes (COLCOT-T2D)RECRUITINGINTERVENTIONALAspirin, Aspirin Placebo, Colchicine
NCT05503225Colchicine Use in Intracranial Atherosclerotic Disease - a Pilot Open-labelled Randomized TrialRECRUITINGINTERVENTIONALColchicine 0.5 MG
NCT04789681Single Arm Phase II Trial Using Canakinumab for the Prevention of Lung Cancer (Can-Prevent-Lung)RECRUITINGINTERVENTIONALCanakinumab, Quality-of-Life Assessment
NCT04774159Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk: A Randomized TrialRECRUITINGINTERVENTIONALColchicine 0.5 MG Oral Tablet, Colchicine-Placebo
NCT04381936Randomised Evaluation of COVID-19 TherapyRECRUITINGINTERVENTIONALLopinavir-Ritonavir, Corticosteroid, Hydroxychloroquine
NCT04496947Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind StudyRECRUITINGINTERVENTIONALStress Reduction
NCT02939573A Randomized Multicenter Study for Isolated Skin VasculitisRECRUITINGINTERVENTIONALColchicine, Dapsone, Azathioprine
NCT07586150Personalised Pharmaco-Lifestyle Interventions for Severe Mental Illnesses Enhanced by Digital Health and Immersive TechnologiesNOT YET RECRUITINGINTERVENTIONALSemaglutide (SEMA), Exercise module, Anti-inflammatory diet module
NCT07661030The Impact of Initiating Dotinurad Urate-Lowering Therapy at Different Time Windows on Gout Flare Resolution Time: A Multicenter, Randomized, Parallel-Controlled StudyNOT YET RECRUITINGINTERVENTIONALDotinurad, colchicine, etoricoxib
NCT07611019Randomized, Double-Blind, Placebo-Controlled Trial of Colchicine to Prevent Post-Operative Atrial Fibrillation After CABG With Strategy-Stratified RandomizationENROLLING BY INVITATIONINTERVENTIONALColchicine 0.5 MG oral tablet twice daily, Placebo Oral Tablet
NCT07461961CORTISHOCK-P: A Randomized Pilot Trial of Corticosteroids as a Pharmacologic Adjunct to Temporary Mechanical Circulatory Support in Inflammation-Enriched Heart Failure Cardiogenic ShockNOT YET RECRUITINGINTERVENTIONALMethylprednisone, Standard of Care (SOC)
NCT07232069Prospective RandomizEd Evaluation and Management of Premature aTherosclerosisNOT YET RECRUITINGINTERVENTIONALRosuvastatin 20 Mg Oral Tablet, Colchicine 0.5 MG Oral Tablet Once Daily, Placebo
NCT07654231Reducing Inflammation to Improve Vascular and Bone Outcomes With Low-dose Colchicine in CKD: A Pilot Randomized Open-Label Trial (RESOLVE-CKD Trial)NOT YET RECRUITINGINTERVENTIONALLow-dose Colchicine at 0.5mg daily, Usual Care
NCT07571681Colchicine as a Novel Anti-Inflammatory Strategy in Autoimmune and Subacute Thyroiditis: A Prospective Three-Arm Randomized Controlled TrialNOT YET RECRUITINGINTERVENTIONALcolchicine, Prednisolone, NSAID
NCT06396858A 2 x 2 Factorial Randomized Clinical Trial Evaluating Anti-inflammatory and Anti-thrombotic Strategy in Acute Ischemic StrokeNOT YET RECRUITINGINTERVENTIONALRivaroxaban 2.5 Mg Oral Tablet, Colchicine 0.5 MG, Placebo Rivaroxaban
NCT07566325Effects of Avocado Consumption on Inflammation and Insulin Sensitivity in Adults With Elevated High Sensitivity-C-reactive Protein (Hs-CRP): A Randomized, Controlled Crossover TrialNOT YET RECRUITINGINTERVENTIONALAvocado, Control
NCT07536373Colchicine in Chronic Limb-Threatening Ischemia for Reduction of Complications and Limb Events in AsiaNOT YET RECRUITINGINTERVENTIONALColchicine 0.5 MG Oral Tablet Once Daily, Placebo
NCT07476625Efficacy and Safety of Thalidomide in Treating Pediatric PFAPA Syndrome: A Multicenter Randomized Controlled TrialNOT YET RECRUITINGINTERVENTIONALThalidomide (50mg), Colchicine
NCT07462325Proteomic Changes Before and After Colchicine Treatment in hsCRP-Elevated Coronary Heart Disease Patients: A Randomized Controlled Open-Label StudyNOT YET RECRUITINGINTERVENTIONALcolchicine
NCT06936709Effect of Colchicine in the Perioperative Period on Reducing Post-Operative Pain in Total Knee ArthroplastyNOT YET RECRUITINGINTERVENTIONALColchicine 1.8 mg (loading dose) + Dextrose Oral Placebo, Colchicine 1.8 mg + 0.6 mg, Dextrose Oral Placebo
NCT07035405Colchicine for Secondary Prevention After Ischemic Stroke (CHANCE-3 EX): a Multicenter, Double-blind, Placebo-controlled, Randomized Clinical TrialNOT YET RECRUITINGINTERVENTIONALColchicine 0.5 mg, Placebo colchicine
NCT06765356Pragmatic Evaluation of a Pentaspline Pulsed Field Ablation System to Treat Atrial Fibrillation and Related ArrhythmiasACTIVE NOT RECRUITINGINTERVENTIONALFarapulse Catheter System, Low-dose Colchicine
NCT06847204EFFICACY OF COLCHICINE IN IMPROVING CLINICAL OUTCOMES IN PATIENTS WITH MILD TO MODERATE COVID-19 PNEUMONIA IN LAHORE: A RANDOMIZED CONTROL TRIALCOMPLETEDINTERVENTIONALColchicine 0.5 MG Oral Tablet
NCT07280572RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)ENROLLING BY INVITATIONINTERVENTIONALMetformin, colchicine

Genetic associations (166)

showing top 80 by significance
VariantGene(s)TraitpOR/βStudy
IL6R1e-58770.9662 unit increaseGCST90012025
IL6R1e-41641.135 unit decreaseGCST90248076
IL6R1e-11011.11 unit increaseGCST90241647
IL6R1e-4500.9926965 unit decreaseGCST006585
IL6R1e-4360.0914524 unit increaseGCST009777
IL6R1e-3540.8864 unit increaseGCST90179338
IL6R1e-3520.274906 decreaseGCST90314285
IL6R1e-3460.8864 unit increaseGCST90425952
IL6R1e-3240.09 unit decreaseGCST90029070
IL6R1e-3150.0827 unit decreaseGCST90018950
IL6R1e-3140.8592 unit increaseGCST90427260
IL6R1e-3110.21150441 unit increaseGCST90469604
IL6R1e-3031.14168 unit increaseGCST90161983
IL6R1e-2970.81 unit increaseGCST009731
IL6R1e-2890.9145 unit increaseGCST90422753
IL6R1e-2651.208 unit increaseGCST90101211
IL6R1e-1960.41426122 unit increaseGCST90469602
IL6R1e-1940.9824 unit increaseGCST010104
IL6R1e-1900.060925 unit increaseGCST90179146
IL6R1e-1900.87 unit increaseGCST90137590
IL6R1e-1290.088 unit increaseGCST007614
IL6R1e-1260.094 unit decreaseGCST007615
IL6R1e-1220.090997 unit increaseGCST012198
IL6R1e-1061.127 unit increaseGCST90277669
IL6R1e-970.0619 unit decreaseGCST90019499
IL6R1e-93—GCST010900
IL6R1e-791.45 unit increaseGCST90238816
IL6R1e-771.44 unit increaseGCST90237561
IL6R1e-751.45 unit increaseGCST90234458
IL6R1e-730.084 unit decreaseGCST90503209
IL6R1e-730.590051 unit increaseGCST90274898
IL6R1e-640.05412 unit decreaseGCST90475511
IL6R1e-63—GCST002665
IL6R1e-620.156 unit decreaseGCST90012005
IL6R1e-620.030645195 unit decreaseGCST90468060
IL6R1e-610.00378274 unit increaseGCST90013406
IL6R1e-580.84 unit increaseGCST009561
IL6R1e-57—GCST000189
IL6R1e-53—GCST009159
IL6R1e-490.108 unit increaseGCST90448664
IL6R1e-480.079 unit increaseGCST000965
IL6R1e-470.116 unit decreaseGCST90275066
IL6R1e-450.0289 unit decreaseGCST90018942
IL6R1e-450.168 unit decreaseGCST90274815
IL6R1e-451.04GCST90244787
IL6R1e-430.04195 unit decreaseGCST90475508
IL6R1e-431.123891 unit increaseGCST90441060
rs61812598IL6Rcoronary artery disorder1e-42—GCST90129546
IL6R1e-42—GCST90129546
IL6R1e-421.10217 unit increaseGCST90441163
IL6R1e-411.107304 unit increaseGCST90441398
rs12730935IL6RIschemic stroke1e-39—GCST90129553
IL6R1e-39—GCST90129553
IL6R1e-39—GCST90129557
IL6R1e-38—GCST90129560
IL6R1e-380.0574 unit decreaseGCST011350
IL6R1e-37—GCST90129539
IL6R1e-37—GCST90129558
IL6R1e-37—GCST90129559
IL6R1e-360.0115 unit decreaseGCST003194
IL6R1e-360.279 ng/mL increaseGCST90085746
IL6R1e-350.017566 unit increaseGCST90179148
IL6R1e-340.1091864 unit decreaseGCST008055
IL6R1e-3111.7 z-score increaseGCST90011900
rs12126142IL6Rabdominal aortic aneurysm1e-300.0939 unit decreaseGCST90432152
IL6R1e-300.03535 unit decreaseGCST90475514
IL6R1e-300.0939 unit decreaseGCST90432152
IL6R1e-29—GCST004000
IL6R1e-290.0115 unit increaseGCST004122
IL6R1e-280.0114 unit increaseGCST004121
IL6R1e-270.021447 SD unit increaseGCST90002322
IL6R1e-270.011 unit decreaseGCST002147
IL6R1e-270.020283125 unit increaseGCST90468091
IL6R1e-260.03516 unit decreaseGCST90475505
IL6R1e-260.1197 unit decreaseGCST012480
IL6R1e-240.02 mmol/L increaseGCST90501111
IL6R1e-23—GCST90002344
IL6R1e-230.03261 unit decreaseGCST90479672
IL6R1e-230.018266788 unit increaseGCST90468090
IL6R1e-220.231 unit decreaseGCST010504