B
Systemic lupus erythematosus
Inflammatory & ImmuneDisease / conditionrisknon modifiable
34
evidence score
Also known as: lupus, lupus erythematosus, systemic lupus erythematosus (SLE)
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 16meta-analyses: 9.1trials: 9genetic: 0MR bonus:
References (39)
2 meta-analyses / systematic reviews- METAMetabolomics Signatures of Atherosclerosis in Cardiovascular Disease: A Narrative Systematic Review. — Journal of clinical medicine 2025 · PMID 41303064
- METARheumatic disease and carotid intima-media thickness: a systematic review and meta-analysis. — Arteriosclerosis, thrombosis, and vascular biology 2010 · PMID 20150560
- Immunomodulation for accelerated atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus. — Autoimmunity reviews 2025 · PMID 39894242
- Association between triglyceride-glucose index and subclinical carotid atherosclerosis in systemic lupus erythematosus: a cohort-based study. — Frontiers in immunology 2025 · PMID 40636109
- Insights into renal damage in hyperuricemia: Focus on renal protection (Review). — Molecular medicine reports 2024 · PMID 39717954
- SARS-CoV-2 infection and SLE: endothelial dysfunction, atherosclerosis, and thrombosis. — Clinical rheumatology 2023 · PMID 36622519
- Gut Microbiota and Cardiovascular Disease: Evidence on the Metabolic and Inflammatory Background of a Complex Relationship. — International journal of molecular sciences 2023 · PMID 37240434
- Accelerated Atherosclerosis and Management of Cardiovascular Risk in Autoimmune Rheumatic Diseases: An Updated Review. — Current problems in cardiology 2023 · PMID 37506959
- Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus. — EBioMedicine 2023 · PMID 37725854
- Atherosclerosis in Systemic Lupus Erythematosus. — Current atherosclerosis reports 2023 · PMID 37768411
- The role of neutrophils in rheumatic disease-associated vascular inflammation. — Nature reviews. Rheumatology 2022 · PMID 35039664
- EULAR recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, including systemic lupus erythematosus and antiphospholipid syndrome. — Annals of the rheumatic diseases 2022 · PMID 35110331
- Systemic Lupus Erythematosus and Cardiovascular Disease: A Mendelian Randomization Study — Frontiers in Immunology 2022 · PMID 35734181
- Systemic lupus erythematosus and cardiovascular disease. — Journal of internal medicine 2022 · PMID 35982610
- Cardiovascular Risk Assessment and Impact of Medications on Cardiovascular Disease in Inflammatory Bowel Disease. — Inflammatory bowel diseases 2021 · PMID 32978937
- Arterial stiffness, the hidden face of cardiovascular risk in autoimmune and chronic inflammatory rheumatic diseases. — Autoimmunity reviews 2021 · PMID 34229047
- Cardio-Rheumatology: Two Collaborating Disciplines to Deal with the Enhanced Cardiovascular Risk in Autoimmune Rheumatic Diseases. — Current vascular pharmacology 2020 · PMID 32693768
- Inflammatory Bowel Disease and Atherosclerotic Cardiovascular Disease: JACC Review Topic of the Week. — Journal of the American College of Cardiology 2020 · PMID 33303079
- Common mechanisms and holistic care in atherosclerosis and osteoporosis. — Arthritis research & therapy 2019 · PMID 30630495
- Hemostasis in Allergy. — Seminars in thrombosis and hemostasis 2018 · PMID 29920622
- Systemic Inflammatory Response and Atherosclerosis: The Paradigm of Chronic Inflammatory Rheumatic Diseases. — International journal of molecular sciences 2018 · PMID 29954107
- Impact of the gut microbiome in cardiovascular and autoimmune diseases. — Clinical science (London, England : 1979) 2018 · PMID 30455339
- Carotid intima-media thickness and arterial stiffness in pediatric systemic lupus erythematosus. — Lupus 2017 · PMID 28420050
- Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study — BMJ 2017 · PMID 28536104
- Race/Ethnicity and Cardiovascular Events Among Patients With Systemic Lupus Erythematosus. — Arthritis & rheumatology (Hoboken, N.J.) 2017 · PMID 28598016
- GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk — Journal of Translational Medicine 2017 · PMID 29078787
- Atherosclerosis in Sjögren's syndrome: evidence, possible mechanisms and knowledge gaps. — Clinical and experimental rheumatology 2016 · PMID 26812164
- Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016. — BMC health services research 2016 · PMID 27409075
- [Cardiovascular risk in rheumatic diseases]. — Casopis lekaru ceskych 2016 · PMID 27917637
- Inflammatory bowel disease and risk of coronary heart disease. — Trends in cardiovascular medicine 2015 · PMID 25912602
- Increased Arterial Stiffness in Systemic Lupus Erythematosus (SLE) Patients at Low Risk for Cardiovascular Disease: A Cross-Sectional Controlled Study — PLoS ONE 2014 · PMID 24722263
- Role of fibrinolytic parameters and plasminogen activator inhibitor 1 (PAI-1) promoter polymorphism on premature atherosclerosis in SLE patients. — Lupus 2011 · PMID 21719525
- [Cardiovascular disorders and rheumatic disease]. — Revista espanola de cardiologia 2011 · PMID 21763053
- Review on anti-lipoprotein lipase antibodies. — Clinica chimica acta; international journal of clinical chemistry 2010 · PMID 20673827
- Atherosclerosis in autoimmune rheumatic diseases-mechanisms and clinical findings. — Clinical reviews in allergy & immunology 2009 · PMID 18991025
- Recent corticosteroid use and recent disease activity: Independent determinants of coronary heart disease risk factors in systemic lupus erythematosus? — Arthritis Care & Research 2008 · PMID 18240259
- Cigarette smoking as a risk factor for atherosclerosis and renal disease: novel pathogenic insights. — Current hypertension reports 2007 · PMID 17362674
- The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia. — Journal of autoimmunity 2007 · PMID 17433865
- Correlates of Long Sleep Duration — SLEEP 2006 · PMID 16895254
Clinical trials (7)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT06737380 | A Phase I, Open-Label Study to Evaluate the Safety and Tolerability of Subcutaneous Administration of Umbilical Cord Derived - Mesenchymal Stromal Cell Therapy in Addition to Standard of Care as A Treatment For Active Systemic Lupus Erythematosus | RECRUITING | INTERVENTIONAL | Physical examination, Electrocardiogram, SF-36 questionnaire |
| NCT00610805 | Cardiology Prevention Trial in Systemic Lupus Erythematosus | WITHDRAWN | INTERVENTIONAL | Preventive Cardiology, Usual Care |
| NCT00858884 | Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus | WITHDRAWN | INTERVENTIONAL | Clinical and laboratory evaluations, transesophageal echocardiography, carotid duplex, transcranial duplex, and magnetic resonance of the brain |
| NCT00065806 | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Test the Safety and Efficacy of Lipitor (Atorvastatin) in Reducing the Progression of Carotid IMT in Early Childhood SLE | COMPLETED | INTERVENTIONAL | Atorvastatin, Placebo atorvastatin |
| NCT00120887 | Lupus Atherosclerosis Prevention Study | COMPLETED | INTERVENTIONAL | Atorvastatin |
| NCT07134166 | Observational Registry of Advanced Cardiac Imaging in Systemic Lupus Erythematosus and Other Inflammatory diseaseS | NOT YET RECRUITING | OBSERVATIONAL | data collection |
| NCT03178721 | Regulatory BCells in Systemic Lupus Erythematosus and Its Relation to Atherosclerosis and Disease Activity | UNKNOWN | OBSERVATIONAL | blood sample |
Genetic associations (0)
None linked.