B
Trimethylamine N-oxide
Novel & Emerging BiomarkersLab test / biomarkerriskpartially modifiable
28
evidence score
Also known as: TMAO, tmao, trimethylamine-n-oxide
PREVENT status
Not a PREVENT input variable.
Causal support
observational only
Score components
lit volume: 19.2meta-analyses: 6trials: 3genetic: 0MR bonus:
References (83)
1 meta-analyses / systematic reviews- METAA systematic review of TMAO, microRNAs, and the oral/gut microbiomes in atherosclerosis and myocardial infarction: mechanistic insights and translational opportunities. — Journal of translational medicine 2025 · PMID 41225505
- Cardiovascular Biomarkers: Tools for Precision Diagnosis and Prognosis. — International journal of molecular sciences 2025 · PMID 40244022
- Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health. — Metabolites 2025 · PMID 40278349
- Gut Microbiota and Cardiovascular Diseases: Unraveling the Role of Dysbiosis and Microbial Metabolites. — International journal of molecular sciences 2025 · PMID 40362500
- Gut microbiota and well-being: A comprehensive summary of the special issue. — Pharmacological research 2025 · PMID 40409520
- Microbiota in Gut-Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease. — Comprehensive Physiology 2025 · PMID 40542540
- Trimethylamine-N-oxide (TMAO) and risk of incident cardiovascular events in the multi ethnic study of Atherosclerosis. — Scientific reports 2025 · PMID 40603925
- Tanshinone regulated gut microbiota and TMAO to improve high-fat diet induced atherosclerosis in APOEmice. — BMC microbiology 2025 · PMID 40646462
- Cardiovascular disease and microbiome: focus on ischemic stroke. — Polish archives of internal medicine 2025 · PMID 40838552
- JA845 Postbiotics Alleviate Atherosclerosis via TMAO-Related Gut Microbiota Regulation and JAK/STAT3 Pathway Inhibition. — Nutrients 2025 · PMID 41097105
- Atherosclerotic cardiovascular disease and inflammatory bowel disease: epidemiology, pathogenesis and risk assessment. — Best practice & research. Clinical gastroenterology 2025 · PMID 41350098
- Protocatechuic acid alleviates TMAO-aggravated atherosclerosismitigating inflammation, regulating lipid metabolism, and reshaping gut microbiota. — Food & function 2024 · PMID 38165856
- Trimethylamine-N-oxide and cerebral stroke risk: A review. — Neurobiology of disease 2024 · PMID 38286388
- Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder. — Frontiers in immunology 2024 · PMID 38343539
- Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic. — Journal of translational medicine 2024 · PMID 38622667
- Gut Microbes in Polycystic Ovary Syndrome and Associated Comorbidities; Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics. — Probiotics and antimicrobial proteins 2024 · PMID 38647957
- Puerarin alleviates atherosclerosis via the inhibition ofand its trimethylamine production. — Gut 2024 · PMID 38777572
- TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoEmice via MBOAT2-mediated endoplasmic reticulum stress. — Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 · PMID 39179098
- Trimethylamine N-oxide promotes PERK-mediated endothelial-mesenchymal transition and apoptosis thereby aggravates atherosclerosis. — International immunopharmacology 2024 · PMID 39340998
- Integrated metabolomics and network pharmacology to reveal the mechanisms of Shexiang Baoxin pill against atherosclerosis. — Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 · PMID 39423481
- Gut Microbe-Generated Metabolite Trimethylamine-N-Oxide and Ischemic Stroke. — Biomolecules 2024 · PMID 39595639
- The Gut Microbiome, Microbial Metabolites, and Cardiovascular Disease in People Living with HIV. — Current HIV/AIDS reports 2023 · PMID 36708497
- Gut Microbiota-Derived TMAO: A Causal Factor Promoting Atherosclerotic Cardiovascular Disease? — International journal of molecular sciences 2023 · PMID 36768264
- The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease — International Journal of Molecular Sciences 2023 · PMID 36768722
- Role of the Gut Microbiome in the Development of Atherosclerotic Cardiovascular Disease — International Journal of Molecular Sciences 2023 · PMID 36982492
- Gut-Derived Metabolite, Trimethylamine-N-oxide (TMAO) in Cardio-Metabolic Diseases: Detection, Mechanism, and Potential Therapeutics — Pharmaceuticals 2023 · PMID 37111261
- The possible role of physical activity in the modulation of gut microbiota in chronic kidney disease and its impact on cardiovascular risk: a narrative review. — European review for medical and pharmacological sciences 2023 · PMID 37140322
- Gut microbiota and microbiota-derived metabolites in cardiovascular diseases. — Chinese medical journal 2023 · PMID 37442759
- Gut microbiome and health: mechanistic insights — Gut 2022 · PMID 35105664
- Integrated metagenomics identifies a crucial role for trimethylamine-producing Lachnoclostridium in promoting atherosclerosis. — NPJ biofilms and microbiomes 2022 · PMID 35273169
- Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3 — Gut Microbes 2022 · PMID 35613310
- Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota. — Signal transduction and targeted therapy 2022 · PMID 35794102
- Gut Microbiota and Coronary Plaque Characteristics. — Journal of the American Heart Association 2022 · PMID 36000423
- andas anti-atherosclerotic agents. — Iranian journal of basic medical sciences 2022 · PMID 36159325
- TMAO Upregulates Members of the miR-17/92 Cluster and Impacts Targets Associated with Atherosclerosis. — International journal of molecular sciences 2022 · PMID 36292963
- Gut microbiome and metabolites, the future direction of diagnosis and treatment of atherosclerosis? — Pharmacological Research 2022 · PMID 36460280
- A cross-talk between gut microbiome, salt and hypertension — Biomedicine & Pharmacotherapy 2021 · PMID 33401080
- Microbiota-Mediated Immune Regulation in Atherosclerosis. — Molecules (Basel, Switzerland) 2021 · PMID 33401401
- Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Review — Nutrients 2021 · PMID 33401598
- Trimethylamine N-oxide (TMAO) in human health. — EXCLI journal 2021 · PMID 33746664
- Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome — npj Biofilms and Microbiomes 2021 · PMID 33863898
- The Influence of Gut Microbiota on the Cardiovascular System Under Conditions of Obesity and Chronic Stress. — Current hypertension reports 2021 · PMID 34014393
- Targeting TMAO and its metabolic pathway for cardiovascular diseases treatment. — Journal of diabetes and metabolic disorders 2021 · PMID 34178875
- The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis — International Journal of Molecular Sciences 2021 · PMID 34360839
- Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II-induced hypertension. — Redox biology 2021 · PMID 34474396
- Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy. — Frontiers in cardiovascular medicine 2021 · PMID 34888358
- The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions — EBioMedicine 2020 · PMID 32062353
- Gut microbiota in atherosclerosis: focus on trimethylamine N‐oxide — Apmis 2020 · PMID 32108960
- Trimethylamine N-Oxide Generated by the Gut Microbiota Is Associated with Vascular Inflammation: New Insights into Atherosclerosis — Mediators of Inflammation 2020 · PMID 32148438
- Plasma levels of trimethylamine-N-oxide can be increased with ‘healthy’ and ‘unhealthy’ diets and do not correlate with the extent of atherosclerosis but with plaque instability — Cardiovascular Research 2020 · PMID 32267921
- Gut Microbiota and Cardiovascular Disease. — Circulation research 2020 · PMID 32762536
- Gut Microbiota in Hypertension and Atherosclerosis: A Review. — Nutrients 2020 · PMID 33003455
- Implication of Gut Microbiota in Cardiovascular Diseases — Oxidative Medicine and Cellular Longevity 2020 · PMID 33062141
- Drug Discovery and Development of Novel Therapeutics for Inhibiting TMAO in Models of Atherosclerosis and Diabetes. — Frontiers in physiology 2020 · PMID 33192565
- Gut microbiota-derived metabolites as central regulators in metabolic disorders — Gut 2020 · PMID 33272977
- Dietary metabolism, the gut microbiome, and heart failure. — Nature reviews. Cardiology 2019 · PMID 30410105
- Gut Microbiota, Atherosclerosis, and Therapeutic Targets. — Critical pathways in cardiology 2019 · PMID 31348074
- Amelioration of TMAO through probiotics and its potential role in atherosclerosis. — Applied microbiology and biotechnology 2019 · PMID 31655880
- Gut Microbiota-Dependent Marker TMAO in Promoting Cardiovascular Disease: Inflammation Mechanism, Clinical Prognostic, and Potential as a Therapeutic Target — Frontiers in Pharmacology 2019 · PMID 31803054
- Gut Microbiota Dysbiosis and Increased Plasma LPS and TMAO Levels in Patients With Preeclampsia — Frontiers in Cellular and Infection Microbiology 2019 · PMID 31850241
- The gut microbiota: An emerging risk factor for cardiovascular and cerebrovascular disease. — European journal of immunology 2018 · PMID 29230812
- Altered microbiome in chronic kidney disease: systemic effects of gut-derived uremic toxins — Clinical Science 2018 · PMID 29523750
- Gut microbiota derived metabolites in cardiovascular health and disease. — Protein & cell 2018 · PMID 29725935
- Diet for stroke prevention. — Stroke and vascular neurology 2018 · PMID 30022800
- A Multi-omic Association Study of Trimethylamine N-Oxide — Cell Reports 2018 · PMID 30044989
- Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target — Nutrients 2018 · PMID 30275434
- Interaction between gut microbiome and cardiovascular disease. — Life sciences 2018 · PMID 30385177
- Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism — Lipids in Health and Disease 2018 · PMID 30567573
- The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease — Alzheimer s Research & Therapy 2018 · PMID 30579367
- Trimethylamine N-oxide: breathe new life. — British journal of pharmacology 2017 · PMID 28745401
- Gut Microbiota and Atherosclerosis. — Current atherosclerosis reports 2017 · PMID 28842845
- Balancing Herbal Medicine and Functional Food for Prevention and Treatment of Cardiometabolic Diseases through Modulating Gut Microbiota — Frontiers in Microbiology 2017 · PMID 29167659
- Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB. — Journal of the American Heart Association 2016 · PMID 26903003
- Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease — Drug Metabolism and Disposition 2016 · PMID 27190056
- Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans — Scientific Reports 2016 · PMID 27228955
- Towards understanding brain-gut-microbiome connections in Alzheimer’s disease — BMC Systems Biology 2016 · PMID 27585440
- Intestinal Microbiota Metabolism and Atherosclerosis. — Chinese medical journal 2015 · PMID 26481750
- Dysbiosis of Gut Microbiota With Reduced Trimethylamine-N-Oxide Level in Patients With Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack. — Journal of the American Heart Association 2015 · PMID 26597155
- Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis. — Cell 2015 · PMID 26687352
- The contributory role of gut microbiota in cardiovascular disease — Journal of Clinical Investigation 2014 · PMID 25271725
- Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. — Nature medicine 2013 · PMID 23563705
- Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk — New England Journal of Medicine 2013 · PMID 23614584
- Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. — Nature 2011 · PMID 21475195
Clinical trials (1)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT03416257 | Gut Microbial-related Choline Metabolite Trimethylamine-N-oxide is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection | COMPLETED | OBSERVATIONAL | No intervention |
Genetic associations (0)
None linked.