A
Tumor necrosis factor-alpha
Inflammatory & ImmuneLab test / biomarkerriskpartially modifiable
45
evidence score
Also known as: tnf-alpha, tnf-α, tumor necrosis factor, tumor necrosis factor-α
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 18.7meta-analyses: 20trials: 6genetic: 0MR bonus:
References (73)
8 meta-analyses / systematic reviews- METAHIF-1α and VEGF Immunophenotypes as Potential Biomarkers in the Prognosis and Evaluation of Treatment Efficacy of Atherosclerosis: A Systematic Review of the Literature. — Frontiers in bioscience (Landmark edition) 2025 · PMID 39862086
- METAEffects of TNF-α Inhibitors on Subclinical Atherosclerosis and Endothelial Function in Patients with Psoriatic Arthritis: A Systematic Review. — La Tunisie medicale 2025 · PMID 41848140
- METACombined Aerobic and Resistance Training Improves Body Composition, Alters Cardiometabolic Risk, and Ameliorates Cancer-Related Indicators in Breast Cancer Patients and Survivors with Overweight/Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. — Journal of sports science & medicine 2024 · PMID 38841642
- METAEffects of phytosterols on cardiovascular risk factors: A systematic review and meta-analysis of randomized controlled trials. — Phytotherapy research : PTR 2024 · PMID 39572895
- METAInflammatory and oxidative stress markers in post-traumatic stress disorder: a systematic review and meta-analysis. — Molecular psychiatry 2022 · PMID 35477973
- METABiomarkers of Vascular Inflammation for Cardiovascular Risk Prognostication: A Meta-Analysis. — JACC. Cardiovascular imaging 2021 · PMID 34801448
- METAModerate alcohol consumption and atherosclerosis : Meta-analysis of effects on lipids and inflammation. — Wiener klinische Wochenschrift 2017 · PMID 28762059
- METADepression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis. — Psychosomatic medicine 2004 · PMID 15564343
- Comparative Effects of Different Exercise Types on Cardiovascular Health and Executive Function in Sedentary Young Individuals. — Medicine and science in sports and exercise 2025 · PMID 39780353
- Cardiovascular disease risk in patients with psoriasis receiving biologics targeting TNF-α, IL-12/23, IL-17, and IL-23: A population-based retrospective cohort study. — PLoS medicine 2025 · PMID 40245096
- Challenges and advances in the management of inflammation in atherosclerosis. — Journal of advanced research 2024 · PMID 38909884
- Differentiation and Growth-Arrest-Related lncRNA (): Initial Characterization in Human Smooth Muscle and Fibroblast Cells. — International journal of molecular sciences 2024 · PMID 39273443
- Cadmium contributes to atherosclerosis by affecting macrophage polarization. — Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 · PMID 36639048
- The oft-overlooked cardiovascular complications of inflammatory bowel disease. — Expert review of clinical immunology 2023 · PMID 36722283
- Biologics for Reducing Cardiovascular Risk in Psoriasis Patients — Journal of Clinical Medicine 2023 · PMID 36769825
- Tumor Necrosis Factor Alpha Inhibitors and Cardiovascular Risk in Rheumatoid Arthritis. — Clinical reviews in allergy & immunology 2023 · PMID 38157095
- Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis. — The New England journal of medicine 2022 · PMID 35081280
- Adipokines, adiposity, and atherosclerosis. — Cellular and molecular life sciences : CMLS 2022 · PMID 35503385
- Gut Microbiota and Coronary Plaque Characteristics. — Journal of the American Heart Association 2022 · PMID 36000423
- Pathway-Specific Polygenic Risk Scores Identify Obstructive Sleep Apnea–Related Pathways Differentially Moderating Genetic Susceptibility to Coronary Artery Disease — Circulation Genomic and Precision Medicine 2022 · PMID 36170352
- Biomarkers associated with coronary high-risk plaques. — Journal of thrombosis and thrombolysis 2022 · PMID 36205839
- HOMOCYSTEINE AND CARDIOVASCULAR DISEASE - A CURRENT REVIEW. — Wiadomosci lekarskie (Warsaw, Poland : 1960) 2022 · PMID 36591781
- Cardiovascular Manifestations in Rheumatoid Arthritis. — Cardiology in review 2022 · PMID 36729119
- Cardiovascular Risk Assessment and Impact of Medications on Cardiovascular Disease in Inflammatory Bowel Disease. — Inflammatory bowel diseases 2021 · PMID 32978937
- Cardiovascular Risk in Patients With Psoriasis: JACC Review Topic of the Week. — Journal of the American College of Cardiology 2021 · PMID 33795041
- Circulating miR-155 and JAK2/STAT3 Axis in Acute Ischemic Stroke Patients and Its Relation to Post-Ischemic Inflammation and Associated Ischemic Stroke Risk Factors — International Journal of General Medicine 2021 · PMID 33911894
- Arterial stiffness, the hidden face of cardiovascular risk in autoimmune and chronic inflammatory rheumatic diseases. — Autoimmunity reviews 2021 · PMID 34229047
- Inflammation and tumor progression: signaling pathways and targeted intervention — Signal Transduction and Targeted Therapy 2021 · PMID 34248142
- Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors — Diabetes/Metabolism Research and Reviews 2021 · PMID 34614543
- Lipoprotein(a)-The Crossroads of Atherosclerosis, Atherothrombosis and Inflammation. — Biomolecules 2021 · PMID 35053174
- Vasculoprotective Effects of Vildagliptin. Focus on Atherogenesis. — International journal of molecular sciences 2020 · PMID 32218354
- Inflammation and post-traumatic stress disorder. — Psychiatry and clinical neurosciences 2019 · PMID 30653780
- PMexposure induces systemic inflammation and oxidative stress in an intracranial atherosclerosis rat model. — Environmental toxicology 2019 · PMID 30672636
- Association of Ustekinumab vs TNF Inhibitor Therapy With Risk of Atrial Fibrillation and Cardiovascular Events in Patients With Psoriasis or Psoriatic Arthritis — JAMA Dermatology 2019 · PMID 30916734
- Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome. — Circulation 2019 · PMID 31208196
- Accelerated Atherosclerosis in Rheumatoid Arthritis: Mechanisms and Treatment. — Current pharmaceutical design 2019 · PMID 31208307
- Risk Factors for the Development of Psoriasis — International Journal of Molecular Sciences 2019 · PMID 31491865
- Role of C-Reactive Protein at Sites of Inflammation and Infection — Frontiers in Immunology 2018 · PMID 29706967
- Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system. — International journal of nanomedicine 2018 · PMID 30538461
- Cardiac Impairment in Rheumatoid Arthritis and Influence of Anti-TNFα Treatment. — Clinical reviews in allergy & immunology 2017 · PMID 27342458
- Psoriasis and Cardiovascular Comorbidities: Focusing on Severe Vascular Events, Cardiovascular Risk Factors and Implications for Treatment — International Journal of Molecular Sciences 2017 · PMID 29065479
- Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases — Postgraduate Medicine 2017 · PMID 29065749
- PM2.5 inhalation induces intracranial atherosclerosis which may be ameliorated by omega 3 fatty acids. — Oncotarget 2017 · PMID 29423081
- Circadian misalignment increases cardiovascular disease risk factors in humans. — Proceedings of the National Academy of Sciences of the United States of America 2016 · PMID 26858430
- Obesity and inflammation: the linking mechanism and the complications — Archives of Medical Science 2016 · PMID 28721154
- Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature. — The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2015 · PMID 25959921
- Cardiovascular involvement in inflammatory bowel disease: Dangerous liaisons. — World journal of gastroenterology 2015 · PMID 26361415
- Arterial structure and function in inflammatory bowel disease. — World journal of gastroenterology 2015 · PMID 26523102
- A Comprehensive Review on Metabolic Syndrome — Cardiology Research and Practice 2014 · PMID 24711954
- Low-Grade Systemic Inflammation Connects Aging, Metabolic Syndrome and Cardiovascular Disease — Interdisciplinary topics in gerontology and geriatrics 2014 · PMID 25341516
- Sleep duration, cardiovascular disease, and proinflammatory biomarkers — Nature and Science of Sleep 2013 · PMID 23901303
- The concept of psoriasis as a systemic inflammation: implications for disease management — Journal of the European Academy of Dermatology and Venereology 2012 · PMID 22356630
- Rheumatoid arthritis: cardiovascular manifestations, pathogenesis, and therapy. — Current pharmaceutical design 2012 · PMID 22364129
- Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe Psoriasis — Journal of Investigative Dermatology 2012 · PMID 22763790
- Association Between Tumor Necrosis Factor Inhibitor Therapy and Myocardial Infarction Risk in Patients With Psoriasis — Archives of Dermatology 2012 · PMID 22911151
- Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations — Nutrition & Metabolism 2012 · PMID 23113919
- The levels of adiponectin and leptin and their relation to other markers of cardiovascular risk in patients with psoriasis — Journal of the European Academy of Dermatology and Venereology 2011 · PMID 21349112
- Association Between Biologic Therapies for Chronic Plaque Psoriasis and Cardiovascular Events — JAMA 2011 · PMID 21862748
- Pericardial Adipose Tissue Determined by Dual Source CT Is a Risk Factor for Coronary Atherosclerosis — Arteriosclerosis Thrombosis and Vascular Biology 2009 · PMID 19229071
- Psoriasis comorbidities. — The Journal of dermatological treatment 2008 · PMID 18273720
- Current update on HIV-associated vascular disease and endothelial dysfunction. — World journal of surgery 2007 · PMID 17372667
- Alcohol consumption, cardiovascular health, and endothelial function markers. — Alcohol (Fayetteville, N.Y.) 2007 · PMID 17980786
- Uric acid and inflammatory markers — European Heart Journal 2006 · PMID 16611671
- Hemostasis alterations in metabolic syndrome (review). — International journal of molecular medicine 2006 · PMID 17016629
- Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease — European Heart Journal 2006 · PMID 17056702
- Resistin Is an Inflammatory Marker of Atherosclerosis in Humans — Circulation 2005 · PMID 15710760
- Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis — Arthritis Research & Therapy 2005 · PMID 15899050
- Selective Activation of Inflammatory Pathways by Intermittent Hypoxia in Obstructive Sleep Apnea Syndrome — Circulation 2005 · PMID 16246965
- Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease. — Circulation 2004 · PMID 15117849
- Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease — New England Journal of Medicine 2004 · PMID 15201411
- Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women — New England Journal of Medicine 2004 · PMID 15602020
- Anti-inflammatory effects of alpha-tocopherol. — Annals of the New York Academy of Sciences 2004 · PMID 15753145
- Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly. — Cardiovascular research 2004 · PMID 15820196
Clinical trials (3)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT01548768 | RHYTHM (RHeumatoid Arthritis studY of THe Myocardium): How Rheumatoid Arthritis (RA) and Tumor Necrosis Factor (TNF) Inhibitors Affect the Myocardial Structure and Function. | COMPLETED | INTERVENTIONAL | TNF inhibitors, DMARDs |
| NCT00477191 | Effects of TNF-alpha Antagonism (Etanercept) in Patients With the Metabolic Syndrome and Psoriasis | TERMINATED | INTERVENTIONAL | Etanercept |
| NCT05633290 | CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis (CONDUCT-ICU): A Pilot Study | UNKNOWN | OBSERVATIONAL | CMR, hs-troponin, NT-pro BNP |
Genetic associations (0)
None linked.