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Type 1 diabetes mellitus

Glycemic & MetabolicDisease / conditionrisknon modifiable
36
evidence score

Also known as: t1dm, type 1 diabetes

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 14.6meta-analyses: 6trials: 15genetic: 0MR bonus:

References (28)

1 meta-analyses / systematic reviews

Clinical trials (34)

NCTTitleStatusTypeInterventions
NCT07284511Fully Closed-Loop Glucose Control in Adults With Type 1 Diabetes Using Tirzepatide: a Randomized, Multi-center, Open-label, Non-inferiority, Parallel TrialRECRUITINGINTERVENTIONALTirzepatide, Tandem Control-IQ Automated Insulin Delivery System (with Dexcom G7 CGM), Carbohydrate Counting
NCT07578584Investigation of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneous Weekly Doses of NNC0497-0040 in Healthy Participants, Participants With Overweight or Obesity, and in Participants With Type 1 Diabetes With Overweight or ObesityRECRUITINGINTERVENTIONALNNC0497-0040, Placebo
NCT06609356Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 DiabetesRECRUITINGINTERVENTIONALStudy Visit 1, Placebo, Study Visit 2
NCT06435156A Phase 2 Double-blind Randomised Controlled Trial Studying the Effect of Sotagliflozin Versus Placebo in Individuals With Heart Failure and Type 1 Diabetes.RECRUITINGINTERVENTIONALSotagliflozin, Placebo
NCT06082063Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 DiabetesRECRUITINGINTERVENTIONALAspirin tablet, Semaglutide, Sotagliflozin
NCT05819138Type 1 Diabetes Impacts of Semaglutide on Cardiovascular OutcomesRECRUITINGINTERVENTIONALSemaglutide Pen Injector, Placebo
NCT05179954Apolipoprotein C3-loading of Apolipoprotein B100 Lipoproteins and Cardiovascular Disease in Patients With Type 1 DiabetesRECRUITINGINTERVENTIONALMetabolic testing
NCT07421518Ketone Monitoring Approaches for Diabetic Ketoacidosis Risk Mitigation in People With T1D on Adjunctive SGLT2 InhibitorsNOT YET RECRUITINGINTERVENTIONALSGLT-2 inhibitor (Sotagliflozin), Insulin withdrawal test (IWT)
NCT07225465The Evaluation of Two Response Thresholds to Continuous Ketone Monitoring Information Minimising Ketosis in People With Type 1 Diabetes Treated With DapagliflozinNOT YET RECRUITINGINTERVENTIONALFORXIGA
NCT06922656Can the Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration?NOT YET RECRUITINGINTERVENTIONALDapagliflozin (DAPA), Pioglitazone 45 mg, Placebo
NCT05705869Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure (TARTAN-HF)ACTIVE NOT RECRUITINGINTERVENTIONALNT-proBNP
NCT05283538Comparison of Cardiovascular Risk Stratification in Young People With Type 1 Diabetes by Coronary Calcium Score to ESC/ESA2019 RecommendationsCOMPLETEDINTERVENTIONALCoronary Artery Calcification Realization
NCT04758858Carbohydrates Under Target for Type 1 Diabetes ManagementWITHDRAWNINTERVENTIONALInsulin treatment optimization with participant's usual diet, Abbott's FreeStyle Libre, Three-day food journal
NCT04450563The Effect of Low-dose Empagliflozin on Glucose Control in Adult Patients With Type 1 Diabetes on a Closed-loop Insulin System: a Randomized Cross-over Controlled TrialCOMPLETEDINTERVENTIONAL14-day outpatient intervention
NCT04073927The Butyful Study. Effect of Butyrate on Inflammation and Albuminuria in Patients With Albuminuria, Type 1 Diabetes and Intestinal Inflammation A Randomized, Double-blind, Placebo-controlled StudyUNKNOWNINTERVENTIONALSodium butyrate
NCT03835195Comprehensive Care in Type 1 Diabetes and Associated Outcomes: AIDDA: a Quasiexperimental Study.COMPLETEDINTERVENTIONALDiabetes Disease Management Program, Usual Care Process
NCT03174522The Efficacy and Safety of Intra-arterial Administration of REX-001 to Treat Ischemic Ulcers in Subjects With Critical Limb Ischemia (CLI) Rutherford Category 5 and Diabetes Mellitus: A Pivotal, Placebo-controlled, Double-blind, Parallel-group, Adaptive TrialTERMINATEDINTERVENTIONALREX-001, Placebo
NCT02897219Phase III Study of ASP1941 Double-blind, Parallel-group Study in Combination With Insulin in Patients With Type 1 Diabetes MellitusCOMPLETEDINTERVENTIONALipragliflozin, Placebo, Insulin Therapy
NCT01935765Sleep Apnea in Type 1 Diabetes : Prevalence, Role of Glycemic Control and Autonomic NeuropathyCOMPLETEDINTERVENTIONALPolysomnography, Evaluation of the autonomous nervous system, Clinical examination of the sleep
NCT02862860Influence of Glycaemic Variability on Oxidative Stress and High-density Lipoprotein (HDL) Function in Type-1 DiabetesCOMPLETEDINTERVENTIONALblood sample, urine sample, installation of Holter
NCT00947427Effects of Canakinumab On The Progression of Type 1 Diabetes In New Onset SubjectsCOMPLETEDINTERVENTIONALcanakinumab (anti IL-1beta), Placebo
NCT01098994Pilot and Feasibility Study for a Pharmacogenomic Trial in Type 1 DiabetesCOMPLETEDINTERVENTIONALVitamin E, Dummy pills
NCT01019486Regadenoson Blood Flow in Type 1 Diabetes (RABIT1D)COMPLETEDINTERVENTIONALRegadenoson myocardial perfusion imaging, Regadenoson MRI myocardial blood flow
NCT00444899Clinical and Economic Benefits of Cardiovascular Risk Management by a Dietician in Diabetic PatientsCOMPLETEDINTERVENTIONALIntensive treatment, Normal follow-up
NCT00592072Effect of Medium Chain Fatty Acids on Cognitive Function During Acute Hypoglycemia in Patients With Type 1 DiabetesCOMPLETEDINTERVENTIONALMedium chain fatty acid (Octanoic and Decanoic acid), Splenda (Placebo Control)
NCT06563401Cardiovascular Disease, Mortality and Prognostic Factors in Adult-onset Type 1 DiabetesRECRUITINGOBSERVATIONALprognosis of adult-onset t1d
NCT06890208Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures: an Observational Study in Germany and Italy, Third Wave (CLIMATE-III)COMPLETEDOBSERVATIONALNo intervention
NCT06407154Chronical Illness-related Limitations of the Ability to Cope with Rising Temperatures: an Observational Study, Second Wave (CLIMATE-II)COMPLETEDOBSERVATIONAL
NCT05961163Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures: an Observational Study (CLIMATE)TERMINATEDOBSERVATIONAL
NCT04979377Prevalence of Hyperandrogenism in Young Women With Type 1 Diabetes and Study of the Underlying Pathophysiological MechanismsCOMPLETEDOBSERVATIONALClinical hyperandrogenism assessment, Total testosterone (ng/dL), A1c (%)
NCT04229667Optimising a Community-based Model for Case Identification, Monitoring, and Prevention of Hypertension and Diabetes Among Syrian Refugees in JordanTERMINATEDOBSERVATIONALImproved Community Health Volunteer (CHV) program
NCT02258945Eating Behaviours, Quality of Life and Cardiometabolic Risks in Adults With Type 1 Diabetes Using Continuous Subcutaneous Insulin Infusion Therapy - A Cross-Sectional StudyCOMPLETEDOBSERVATIONAL
NCT02258932Eating Behaviours, Quality of Life and Cardiometabolic Risks in Adults With Type 1 Diabetes Using Continuous Subcutaneous Insulin Infusion Therapy - A Longitudinal StudyCOMPLETEDOBSERVATIONAL
NCT01178957Very-Low-Density-Lipoprotein-Triglyceride(VLDL-TG) Metabolism During Acute HyperglycemiaCOMPLETEDOBSERVATIONALHyperglycemia

Genetic associations (0)

None linked.