C
vascular dysfunction
Imaging & Subclinical DiseaseImaging markerriskpartially modifiable
23
evidence score
Also known as: vascular function, vascular mechanisms
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 7.8meta-analyses: 0trials: 15genetic: 0MR bonus:
References (5)
0 meta-analyses / systematic reviews- Preeclampsia and Vascular Function: A Window to Future Cardiovascular Disease Risk. — Journal of women's health (2002) 2016 · PMID 26779584
- MicroRNAs in lipid metabolism and atherosclerosis. — Best practice & research. Clinical endocrinology & metabolism 2016 · PMID 27923459
- Genome-wide association studies of late-onset cardiovascular disease. — Journal of molecular and cellular cardiology 2015 · PMID 25870159
- Family history of coronary heart disease and markers of subclinical cardiovascular disease: where do we stand? — Atherosclerosis 2013 · PMID 23578356
- Coronary heart disease and depression: a review of recent mechanistic research. — Canadian journal of psychiatry. Revue canadienne de psychiatrie 2006 · PMID 17168248
Clinical trials (44)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT06600178 | Innovative Therapy to Treat Women With Angina With Nonobstructive Coronary Artery Disease (ANOCA) and Coronary Microvascular Disease | RECRUITING | INTERVENTIONAL | Brezavvy 20Mg Oral Tablet, Placebo |
| NCT06681896 | Microvascular Coronary Rehabilitation For Improving Treatment - Feasibility Study | RECRUITING | INTERVENTIONAL | MICROFIT - personalised high intensity interval training exercise rehabilitation and dietary advice |
| NCT06529185 | Effect of Breather on Ventilatory and Vascular Function in Chronic Obstructive Pulmonary Disease Patients With Intermittent Claudication. | RECRUITING | INTERVENTIONAL | The BREATHER, pharmacological treatment |
| NCT06338293 | Using OFR Software to Observe the Effects of Inclisiran Combined With Statins on the Morphology and Vascular Function of Coronary Vulnerable Plaques | RECRUITING | INTERVENTIONAL | Inclisiran sodium, Rosuvastatin |
| NCT05999851 | Multiparametric Assessment of Maternal Vascular Function as a New Diagnostic and Prognostic Tool for Hypertensive Disorders of Pregnancy and Preeclampsia - EDIPE Study | RECRUITING | INTERVENTIONAL | Arterial applanation tonometry, In vivo endothelial glycocalyx measurement, Serum markers of angiogenesis and endothelial dysfunction |
| NCT06683131 | IMpact of PCSK9 inhibitoR initiatiOn Before Percutaneous Coronary Intervention on Coronary microVascular Dysfunction and Events for Acute Myocardial Infarction: a Multi-center, Open-label, Randomized, Controlled Trial | NOT YET RECRUITING | INTERVENTIONAL | Tafolecimab |
| NCT06827691 | Heat Therapy for People with Peripheral Artery Disease: a Randomised Wait-List Controlled Feasibility Trial. | NOT YET RECRUITING | INTERVENTIONAL | Heat Therapy Intervention |
| NCT07590219 | Efficacy, Metabolic and Cardiovascular Effects of Liraglutide in Children Aged 6-12 Years With Severe Obesity: A Randomized Controlled Trial With Advanced Echocardiographic Assessment | ACTIVE NOT RECRUITING | INTERVENTIONAL | Liraglutide (Saxenda) 6Mg/Ml Inj Pen 3Ml |
| NCT06217120 | Reversing Microvascular Dysfunction in Heart Failure With Ejection Fraction > 40% Using Colchicine (The COL-Micro-HF Study) | UNKNOWN | INTERVENTIONAL | Colchicine, Placebo |
| NCT05725486 | Effects of N-3 Polyunsaturated Fatty Acids Enriched Chicken Meet on Cardiovascular Function | UNKNOWN | INTERVENTIONAL | N-3 PUFAs Chicken Meet, Regular Chicken Meet |
| NCT05611021 | Acute Responses to Arm-Crank Exercise on Cardiovascular Function of Patients With Peripheral Artery Disease: Randomized Crossover Study | COMPLETED | INTERVENTIONAL | Exercise |
| NCT05294887 | First Prospective Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive Coronary Artery Disease After Coronary Physiological Testing | UNKNOWN | INTERVENTIONAL | Bisoprolol, Diltiazem, Placebo |
| NCT03917251 | The Effects of Trans Venous Cardiac Pacing on Coronary Microvascular Function and Hemodynamics | WITHDRAWN | INTERVENTIONAL | Coronary flow and pressure measurement in patients with ventricular pacing |
| NCT04338165 | Effect of Impact of PCSK9 Inhibitors on Coronary Microvascular Dysfunction in Patients With Atherosclerotic Cardiovascular Disease Proved by Myocardial Ischemia and Needing Coronarography : a Monocentric, Prospective, Randomized and Open-label Phase II Trial | UNKNOWN | INTERVENTIONAL | Evolocumab 140 MG/ML [Repatha] |
| NCT04564690 | Effect of Enriched QUARTET® Hen Eggs on Cardiovascular Function in Cardiovascular Patients and Healthy Individuals | UNKNOWN | INTERVENTIONAL | QUARTET® hen eggs (enriched in n-3 PUFA, selenium, vitamin E and lutein), Regular hen eggs |
| NCT04777045 | Efficacy of Diltiazem to Improve Coronary Microvascular Dysfunction: a Randomized Clinical Trial | ACTIVE NOT RECRUITING | INTERVENTIONAL | Diltiazem Hydrochloride, Placebo |
| NCT04073134 | Cholesterol Reduction With Evolocumab and Coronary MicrovascuLar Function and Coronary Flow: The CHORAL Flow Study | TERMINATED | INTERVENTIONAL | Evolocumab, Placebo |
| NCT03837639 | Effects of Arm-crank Exercise Training on Cardiovascular Function of Patients With Peripheral Artery Disease: a Randomized Controlled Trial | UNKNOWN | INTERVENTIONAL | Arm ergometer, Treadmill ergometer, Control group |
| NCT03829046 | The Effects of Evolocumab on Endothelial and Inflammatory Biocellular Markers in Patients With Diabetes and Atherosclerotic Vascular Disease (METCHNIKOFF) | COMPLETED | INTERVENTIONAL | Placebo, Evolocumab |
| NCT04092972 | Safety and Efficacy of Interventional Treatment Through Atherectomy to Improve Vascular Functions and Patency in Symptomatic Peripheral Artery Disease - Pilot Study | UNKNOWN | INTERVENTIONAL | Atherectomy, POBA and DCB |
| NCT03811925 | Local and Systemic Vascular Function Following Drug Coated Balloon vs. Stenting in the Superficial Femoral Artery | UNKNOWN | INTERVENTIONAL | Angioplasty and drug coated balloon of the superficial femoral artery (SFA), Angioplasty and stenting of the superficial femoral artery (SFA) |
| NCT03061253 | Impact on Cardiovascular Function in Smokers Making a Quit Attempt Using E-cigarettes Compared With Smokers Making a Quit Attempt With Prescription Nicotine-Replacement Therapy | COMPLETED | INTERVENTIONAL | Electronic Cigarette and behavioural change support., Nicotine-Free Electronic Cigarette and behavioural change support., Nicotine Replacement Therapy and behavioural change support. |
| NCT03036644 | Effects of Electronic Cigarette Vaporization at High Temperature in Comparison to Tobacco Smoking on Cardiovascular Function and Oxidative Stress in Electronic Cigarette Users and Regular Tobacco Smokers | COMPLETED | INTERVENTIONAL | e-cigarette (PG+VG without nicotine; low temperature), e-cigarette (PG+VG with nicotine; low temperature), e-cigarette (PG+VG without nicotine; high temperature) |
| NCT02910154 | Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower Cohort | COMPLETED | INTERVENTIONAL | Diet, Training, Medication (with statin and ACE-inhibition) |
| NCT02602600 | Effect of Glucagon-like Peptide-1 Stimulation on Coronary Microvascular Dysfunction in Women With Angina Pectoris and no Obstructive Stenosis of Major Coronary Vessels | COMPLETED | INTERVENTIONAL | Liraglutide |
| NCT02660047 | Magnetic Resonance Assessment of Victoza Efficacy in the Regression of Cardiovascular Dysfunction In Type 2 Diabetes Mellitus and South Asian Descent | COMPLETED | INTERVENTIONAL | Liraglutide, Liraglutide - Placebo |
| NCT02761603 | Autonomic and Immuno-Vascular Mechanisms of Antihypertensive Effects of Tai Chi | UNKNOWN | INTERVENTIONAL | Healthy Aging Practice-centered Instruction (HAPI), Tai Chi (CHI) |
| NCT02628301 | Is Microvascular Dysfunction an Early Phenomenon in the Development of Skeletal Muscle Insulin Resistance? A Dietary Intervention Study in Healthy Men | COMPLETED | INTERVENTIONAL | Hypercaloric diet, Normocaloric diet |
| NCT02319733 | Plaque Stabilization and Restoration of Vascular Function by Bioresorbable Vascular Scaffold in Acute Coronary Syndrome Prone Patients | TERMINATED | INTERVENTIONAL | Bioresorbable vascular scaffold |
| NCT01812317 | Effect of Real-fire Training on Vascular Function | COMPLETED | INTERVENTIONAL | Forearm Vascular Study, Badimon Chamber Study |
| NCT01041521 | The Impact of Omega Three Fatty Acids on Vascular Function in HIV | COMPLETED | INTERVENTIONAL | Lovaza |
| NCT00553969 | Efficacy of Coreg CR and Lisinopril on Markers for Cardiovascular Functional and Structural Disease. DETECT (DEtection and Treatment of Early Cardiovascular Disease Trial) | COMPLETED | INTERVENTIONAL | carvedilol phosphate, lisinopril, carvedilol phosphate and lisinopril |
| NCT00686972 | The Effect of Surgically Induced Weight Loss on Endocrine Function, Cardiovascular Function and Body Composition | TERMINATED | INTERVENTIONAL | GLP-1 |
| NCT00587002 | Differences in Epicardial Plaque and Microvascular Function in Women With an Acute Myocardial Infarction | COMPLETED | INTERVENTIONAL | IVUS |
| NCT00246883 | Effect of Regular Exercise on Vascular Function and Cardiovascular Risk in a Sedentary Work Force: The NHLBI "Keep the Beat" Program | COMPLETED | INTERVENTIONAL | Exercise |
| NCT00181181 | The Effect of Statin Use on Vascular Function in Hypertensive Subjects | TERMINATED | INTERVENTIONAL | atorvastatin, placebo |
| NCT00102843 | Effect of Lowering of Fasting Plasma Homocysteine Concentrations Through Supplementation With Betaine or Folic Acid on Vascular Function in Healthy Volunteers | COMPLETED | INTERVENTIONAL | supplementation with folic acid and betaine |
| NCT00126347 | Effect of Lowering of Plasma Homocysteine Concentrations After an Oral Methionine Load on Vascular Function in Healthy Volunteers | COMPLETED | INTERVENTIONAL | supplementation with betaine, serine, and folic acid |
| NCT00029991 | Extract of Ginkgo Biloba (Egb 761) and Vascular Function | COMPLETED | INTERVENTIONAL | Gingko Biloba (Herb) |
| NCT06885970 | The Effect of Cytisine Treatment for Smoking Cessation on Cardiovascular Function in Adult Smokers of Conventional Combustible Cigarettes and New Tobacco Products-Observational Study. | RECRUITING | OBSERVATIONAL | Cytisinicline administration |
| NCT06076551 | Sex Difference of Coronary Microvascular Dysfunction Evaluated by Coronary Flow Reserve in Patients With Non-obstructive Coronary Artery Disease | RECRUITING | OBSERVATIONAL | Adenosine stress echocardiography |
| NCT03132129 | Prevalence and Determinants of Subclinical Cardiovascular Dysfunction in Adults With Type 2 Diabetes Mellitus | RECRUITING | OBSERVATIONAL | Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography, Computed tomography coronary artery calcium scoring |
| NCT07594392 | Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in the St. Jude Lifetime Cohort (SJLIFE) | NOT YET RECRUITING | OBSERVATIONAL | Coronary Artery Calcium Scan, Carotid Artery Ultrasound, Lipoprotein(a) Measurement |
| NCT07363187 | Evaluation of Microvascular Changes by Nailfold Capillaroscopy and Serum ADMA, Von Willebrand Factor, Hs-CRP, and D-dimer Levels in Healthcare Workers Exposed to Chronic Low-Dose Ionizing Radiation | NOT YET RECRUITING | OBSERVATIONAL |
Genetic associations (0)
None linked.