B
Vitamin D deficiency
Novel & Emerging BiomarkersLab test / biomarkerriskmodifiable
41
evidence score
Also known as: 25-hydroxyvitamin d, vitamin d
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 14.1meta-analyses: 11.6trials: 15genetic: 0MR bonus:
References (25)
3 meta-analyses / systematic reviews- METAAssociation of Serum Vitamin D Level and Carotid Atherosclerosis: A Systematic Review and Meta-analysis. — Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2017 · PMID 29171066
- METACirculating vitamin D, calcium and risk of cerebrovascular disease: a systematic review and meta-analysis. — European journal of epidemiology 2012 · PMID 22961293
- METAEffect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis — BMJ 2010 · PMID 20671013
- Associations of serum 25-hydroxyvitamin D concentrations with risks of mortality and cardiovascular disease among individuals with psoriasis. — Journal of the American Academy of Dermatology 2025 · PMID 40378890
- Vitamin D and Cardiovascular Health: A Narrative Review of Risk Reduction Evidence. — Nutrients 2025 · PMID 40647207
- Skeletal Muscle and Cardiovascular Health. — Advances in experimental medicine and biology 2025 · PMID 40879958
- Dietary, macronutrient, micronutrient, and nutrigenetic factors impacting cardiovascular risk markers apolipoprotein B and apolipoprotein A1: a narrative review. — Nutrition reviews 2024 · PMID 37615981
- Effects of vitamin D, omega-3 and a simple strength exercise programme in cardiovascular disease prevention: The DO-HEALTH randomized controlled trial. — The journal of nutrition, health & aging 2024 · PMID 38199870
- Vitamin D and cardiovascular diseases. — Advances in food and nutrition research 2024 · PMID 38777418
- Atorvastatin ameliorated PM-induced atherosclerosis in rats. — Archives of environmental & occupational health 2023 · PMID 36660941
- Vitamin D and cardiovascular disease risk. A literature overview. — Molecular biology reports 2022 · PMID 35364717
- 25-hydroxyvitamin D insufficiency and inflammation increase cardiovascular risk in older people. — Experimental gerontology 2022 · PMID 35661774
- Circulating Biomarkers for Cardiovascular Disease Risk Prediction in Patients With Cardiovascular Disease — Frontiers in Cardiovascular Medicine 2021 · PMID 34660715
- RETRACTED: Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk — European Heart Journal 2021 · PMID 34891159
- Area-based socioeconomic status and mortality: the Ludwigshafen Risk and Cardiovascular Health study. — Clinical research in cardiology : official journal of the German Cardiac Society 2019 · PMID 31144063
- Chronic Kidney Disease Diagnosis and Management — JAMA 2019 · PMID 31573641
- Periodontitis and platelet count: A new potential link with cardiovascular and other systemic inflammatory diseases — Journal Of Clinical Periodontology 2018 · PMID 30133784
- Association of Non-HDL Cholesterol, Homocysteine and Vitamin D in Acute Coronary Syndrome. — The Journal of the Association of Physicians of India 2018 · PMID 31324079
- Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands. — Current medicinal chemistry 2017 · PMID 27915991
- Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity — Circulation 2016 · PMID 26746178
- Folic Acid and Vitamins D and B12 Correlate With Homocysteine in Chinese Patients With Type-2 Diabetes Mellitus, Hypertension, or Cardiovascular Disease — Medicine 2016 · PMID 26871790
- Inflammation, oxidative stress and renin angiotensin system in atherosclerosis — World Journal of Biological Chemistry 2015 · PMID 26322175
- Psoriasis. — The journal of the Royal College of Physicians of Edinburgh 2013 · PMID 24350319
- Vitamin D Deficiency and Risk of Cardiovascular Disease — Circulation 2008 · PMID 18180395
- 25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men<subtitle>A Prospective Study</subtitle> — Archives of Internal Medicine 2008 · PMID 18541825
Clinical trials (31)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07400757 | The Role of Statin and Vitamin D for the Treatment of Thyroid Eye Disease | RECRUITING | INTERVENTIONAL | Atorvastatin (Lipitor), Vitamin D |
| NCT07130305 | is There an Effect of Addition of Body Vibration to Intake of Vitamin D on Some Outcomes of Familial Mediterranean Fever | RECRUITING | INTERVENTIONAL | whole body vibration plus usual care, usual care |
| NCT06765265 | Impact of Atorvastatin Versus Rosuvastatin on 25 Hydroxy Vitamin D Levels in Patients With Acute Coronary Syndrome | RECRUITING | INTERVENTIONAL | Rosuvastatin 20 mg/day, Atorvastatin 40 mg |
| NCT05937789 | Effects of Early Vitamin D3 Supplementation on Clinical Outcomes for Critically Ill Patients | RECRUITING | INTERVENTIONAL | Vitamin D3, Medium Chain Triglycerides (MCT) |
| NCT05449522 | Effects of High Doses of Liquid Vitamin D Supplementation on Clinical Outcomes in Critically Traumatic Patients. | RECRUITING | INTERVENTIONAL | Vitamin D, Placebo |
| NCT03188796 | The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients With Severe Vitamin D Deficiency: a Multicenter, Placebo-controlled Double-blind Phase III Randomized Controlled Trial (RCT) | RECRUITING | INTERVENTIONAL | Cholecalciferol, Placebo |
| NCT07127796 | A Non-inferiority, Randomized Double-blind Controlled Clinical Trial Comparing the Effect of Vitamin D Supplementation Derived From Fish Waste Versus Synthetic Vitamin D on Plasma Vitamin D Levels and Anthropometric and Laboratory Correlates in Healthy Subjects With Suboptimal Blood Vitamin D Levels | NOT YET RECRUITING | INTERVENTIONAL | Dietary Supplement - Fish-derived Vitamin D, Dietary Supplement - Synthetic Vitamin D |
| NCT07117643 | Influence of Remote Ischemic Preconditioning Reperfusion/Reocclusion Training and Physical Exercises on the Inflammatory, Angiogenic, Neurotrophic and Anti-tumor Potential of Human Serum in Vivio/in Vitro Studies - Role of Vitamin d and Iron Metabolism | ENROLLING BY INVITATION | INTERVENTIONAL | Ischemic Preconditioning |
| NCT05650151 | Peri-operative Vitamin D Therapy for Patients With Hepatocellular Carcinoma Receiving Hepatectomy | UNKNOWN | INTERVENTIONAL | Vitamin D, Placebo |
| NCT06690723 | Exploring the Synergistic Effect of Vitamin D and SGLT-2 Inhibitor on Cardio-metabolic Markers and the Renin Angiotensin Aldosterone System in CPAP-naive Obstructive Sleep Apnea Population | COMPLETED | INTERVENTIONAL | Dapagliflozin (Forxiga), Vitamin D3 ( Colecalciferol), Vitamin D3 plus Dapagliflozin |
| NCT05331807 | The Effects of Combined Omega-3 and Vitamin D Supplementation on Nutritional Status, Quality of Life and Inflammatory Markers Among the Breast Cancer Women in Gaza Strip | COMPLETED | INTERVENTIONAL | Omega-3 FA, Vitamin D, Combined Omega-3 and Vitamin D Supplementation |
| NCT05806723 | Effects of High Intensity Statin Therapy on Steroid Hormones and Vitamin D in Type 2 Diabetic Men | COMPLETED | INTERVENTIONAL | Atorvastatin 40 Mg Oral Tablet |
| NCT04768023 | Influence of 12 Weeks Vitamin D Supplementation Combined With Physical Activity on Blood and Functional Parameters and Quality of Life in Parkinson's Disease Patients Treated With Deep Brain Stimulation | COMPLETED | INTERVENTIONAL | Juvit D3, Placebo |
| NCT04126330 | Effect of Omega-3 and Probiotic Dietary Supplements on Elevated High Sensitivity C-reactive Protein (Hs-CRP) as a Marker of Low-grade Inflammation: Targeting Inflammation and Intestinal Barrier Function in the Elderly and Obese | COMPLETED | INTERVENTIONAL | Probiotic, Omega-3, Vitamin D supplement, Placebo |
| NCT04005573 | Assessing the Combined Effect of Omega-3 Fatty Acid and Vitamin D3 on Lipid Profile Levels and Oxidized Low Density Lipoprotein: a Randomized Controlled Trial in Males and Females With Vitamin D Deficiency | COMPLETED | INTERVENTIONAL | VD3, omega 3- FA, VD3 and omega- 3FA |
| NCT03600311 | Using Resistance Exercise and Protein Consumption to Protect Bone Health During Weight Loss | COMPLETED | INTERVENTIONAL | Caloric Restriction, Post-Exercise Protein, Energy Balance |
| NCT03310307 | Vitamin D3 Treatment Decreases Serum Total Homocysteine Concentrations of Overweight Reproductive Women: Randomized Placebo Controlled Clinical Trail | COMPLETED | INTERVENTIONAL | Vit D, Placebo |
| NCT01588795 | Renal Denervation in Patients With Diabetic Nephropathy and Persistent Proteinuria | COMPLETED | INTERVENTIONAL | Percutaneous renal denervation and TMNS, Standardized antiproteinuric medication regimen includes an angiotensin receptor blocker , a diuretic , 25OH vitamin D3 and a statin |
| NCT01404195 | High-protein Nutritional Intervention Based on β-hydroxy-β-methylbutirate, Vitamin D3 and Calcium on Obese and Lean Aged Patients With Hip Fractures and Sarcopenia. The HIPERPROT-GER Study. | COMPLETED | INTERVENTIONAL | Ensure Plus Advance |
| NCT01493648 | Muscle-Related Side Effects of Statins: Functional Impact, Mechanisms, and Potential Relief With Vitamin D Supplementation | COMPLETED | INTERVENTIONAL | Vitamin D, Placebo |
| NCT01225263 | Combined Statin and Vitamin D Therapy for Prophylactic Treatment of Episodic Migraine | COMPLETED | INTERVENTIONAL | Simvastatin, Vitamin D, Placebo |
| NCT01183442 | Effects of Vitamin D Supplementation in Coronary Artery Disease Patients With Postchallenge Hyperglycemia and Vitamin D Deficiency on Endothelial Function and Insulin Sensitivity | TERMINATED | INTERVENTIONAL | vitamin D |
| NCT01008384 | The Effect of Vitamin D Repletion on Small LDL Particle Number in Subjects at Elevated Cardiovascular Risk | COMPLETED | INTERVENTIONAL | Vitamin D3 |
| NCT01101698 | Influence of Vitamin K2 Administration on Vessel Calcification Markers in Patients With Chronic Kidney Disease | UNKNOWN | INTERVENTIONAL | Vitamin K2+10μg cholecalciferol, Vitamin D |
| NCT00879970 | AVANDIA CV Outcomes Study: Thiazolidinedione Intervention With Vitamin D Evaluation (TIDE) A Multicenter Randomized Double-Blind Placebo-Controlled Trial of a Thiazolidinedione or Placebo and of Vitamin D or Placebo In People With Type 2 Diabetes at Risk For Cardiovascular Disease | TERMINATED | INTERVENTIONAL | pioglitazone, rosiglitazone, placebo |
| NCT00876928 | Effect of Vitamin D Supplementation on Pre-Diabetes in a Minority Population | COMPLETED | INTERVENTIONAL | vitamin D, placebo |
| NCT00472654 | Nutritional Regulation of Bone - Aim 3 | COMPLETED | INTERVENTIONAL | Weight Loss, Vitamin D 2500 IU, Weight Maintenance |
| NCT07467161 | Impact of Vitamin D Deficiency on Insulin Resistance Assessed by Triglyceride Glucose Index in Type 2 Diabetic Patients | NOT YET RECRUITING | OBSERVATIONAL | |
| NCT04651101 | Can Vitamin D Deficiency be a Risk Factor of Coronary Artery Disease? | COMPLETED | OBSERVATIONAL | coronary angiography |
| NCT03401619 | Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study: an Ambispective, Multicentre, Open Cohort Study | ACTIVE NOT RECRUITING | OBSERVATIONAL | Exercise,Nutrition,Bisphosphonates,Statins,Calcitonin,Vitamin D,et al. |
| NCT01080274 | Vitamin D and Zinc Levels in Patients Undergoing Ergometry Test | UNKNOWN | OBSERVATIONAL |
Genetic associations (0)
None linked.