Framingham (2008 general CVD)
Framingham General Cardiovascular Risk Profile (D'Agostino 2008)
#14
coverage rank
United States200810-yearGeneral CVD (CHD, stroke, PAD, heart failure)8 inputs
Adults 30-74, no CVD (Framingham Heart Study)
7
atlas factors covered
6
strongly-evidenced (A/B)
5
of 15 categories
Strengths
- Landmark, extensively validated general-CVD model covering CHD, stroke, PAD and heart failure
- Simple office-based inputs; foundation for most later scores
Weaknesses
- Derived from a predominantly White suburban US cohort (Framingham); overestimates in many modern/European/Asian populations
- No race/ethnicity, deprivation, renal, or inflammatory inputs
- Dated event rates; largely superseded by PCE/PREVENT in the US
Input variables (8)
| Input | Maps to atlas factor | Category | Grade | Note |
|---|---|---|---|---|
| Age | Age | Demographic & Social | A | |
| Sex | Sex | Demographic & Social | C | |
| Total cholesterol | Total cholesterol | Lipids & Lipoproteins | A | |
| HDL cholesterol | HDL cholesterol | Lipids & Lipoproteins | A | |
| Systolic blood pressure | Systolic blood pressure | Blood Pressure & Hemodynamics | A | |
| Treatment for hypertension | — derived / not in atlas | — | — | treatment/medication-use variable; not a factor in atlas |
| Current smoking | Cigarette smoking | Lifestyle & Behavioral | A | |
| Diabetes mellitus | Type 2 diabetes mellitus | Glycemic & Metabolic | A |
References
- General cardiovascular risk profile for use in primary care: the Framingham Heart Study — Circulation 2008 · PMID 18212285
- Prediction of coronary heart disease using risk factor categories (Framingham) — Circulation 1998 · PMID 9603539