Astro-CHARM
Astronaut Cardiovascular Health and Risk Modification CAC calculator
#5
coverage rank
United States (multi-ethnic)201810-yearAtherosclerotic CVD (hard CHD + stroke)11 inputs
Adults 40-65 without CVD (pooled MESA + Dallas Heart + others)
10
atlas factors covered
8
strongly-evidenced (A/B)
7
of 15 categories
Strengths
- Pooled multi-cohort CAC-based ASCVD calculator; adds family history and CAC to standard factors
- Predicts hard ASCVD (CHD + stroke) unlike CHD-only MESA score
- Improves reclassification over factor-only models
Weaknesses
- Requires CT coronary calcium scan
- Age range ~40-65; US-derived multi-ethnic pooled cohorts
- No renal, inflammatory, or lipid-subfraction inputs
Input variables (11)
| Input | Maps to atlas factor | Category | Grade | Note |
|---|---|---|---|---|
| Age | Age | Demographic & Social | A | |
| Sex | Sex | Demographic & Social | C | |
| Race/ethnicity | Race/ethnicity | Demographic & Social | A | |
| Total cholesterol | Total cholesterol | Lipids & Lipoproteins | A | |
| HDL cholesterol | HDL cholesterol | Lipids & Lipoproteins | A | |
| Systolic blood pressure | Systolic blood pressure | Blood Pressure & Hemodynamics | A | |
| Treated hypertension | — derived / not in atlas | — | — | treatment/medication-use variable; not a factor in atlas |
| Current smoking | Cigarette smoking | Lifestyle & Behavioral | A | |
| Diabetes mellitus | Type 2 diabetes mellitus | Glycemic & Metabolic | A | |
| Family history of heart attack | Family history of myocardial infarction | Genetic & Family History | D | |
| Coronary artery calcium (Agatston) | Coronary artery calcium score | Imaging & Subclinical Disease | A |
References
- Astronaut Cardiovascular Health and Risk Modification (Astro-CHARM) Coronary Calcium ASCVD Risk Calculator — Circulation 2018 · PMID 30354651