Reynolds Risk Score
Reynolds Risk Score (women 2007 / men 2008)
#7
coverage rank
United States200710-yearCVD (MI, stroke, coronary revascularization, cardiovascular death)9 inputs
Healthy adults without diabetes (Women's Health Study / men's cohort)
9
atlas factors covered
8
strongly-evidenced (A/B)
7
of 15 categories
Strengths
- First major score to add hs-CRP and family history to standard factors, improving reclassification
- Sex-specific; validated in healthy non-diabetic cohorts
Weaknesses
- Derived largely in healthcare-professional cohorts (Women's Health Study), limiting generalizability
- Excludes people with diabetes in original derivation
- Small input set; no renal, ethnicity, deprivation, or imaging inputs
- Requires hs-CRP which is not universally measured
Input variables (9)
| Input | Maps to atlas factor | Category | Grade | Note |
|---|---|---|---|---|
| Age | Age | Demographic & Social | A | |
| Sex | Sex | Demographic & Social | C | |
| Systolic blood pressure | Systolic blood pressure | Blood Pressure & Hemodynamics | A | |
| Total cholesterol | Total cholesterol | Lipids & Lipoproteins | A | |
| HDL cholesterol | HDL cholesterol | Lipids & Lipoproteins | A | |
| hs-CRP | High-sensitivity C-reactive protein | Inflammatory & Immune | A | |
| Current smoking | Cigarette smoking | Lifestyle & Behavioral | A | |
| Parental history of MI before 60 | Family history of premature coronary heart disease | Genetic & Family History | B | |
| HbA1c (if diabetic; women model) | Hemoglobin A1c | Glycemic & Metabolic | A |
References
- Development and validation of improved algorithms for the assessment of global cardiovascular risk in women (Reynolds Risk Score) — JAMA 2007 · PMID 17299196
- C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men — Circulation 2008 · PMID 18997194